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A kind of oil-in-water nanoemulsion matrix

An oil-in-water type, nanoemulsion technology, applied in the field of medicine, to achieve the effect of simple production process, strong stability and convenient production

Active Publication Date: 2019-04-16
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there are very few studies on nanoemulsion matrix, therefore, the research on nanoemulsion matrix is ​​imperative

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: oil-in-water type nanoemulsion matrix, including isopropyl palmitate 10% and mixed surfactant 90% by mass percentage; Isopropyl palmitate is placed in 80 ℃ of water baths, heated and melted, and Add the mixed surfactant into the isopropyl palmitate, stir, dissolve evenly, and cool;

[0011] The mixed surfactant is a composition of a surfactant and a co-surfactant at a mass ratio of 4:1;

[0012] The surfactant is composed of Tween 80 and polyoxyethylene hydrogenated castor oil, the mass ratio of the two is, Tween 80:polyoxyethylene hydrogenated castor oil=2:1;

[0013] The co-surfactant is glycerol.

Embodiment 2

[0014] Embodiment 2: oil-in-water nanoemulsion matrix, including isopropyl palmitate 20% and mixed surfactant 80% by mass percentage; Isopropyl palmitate is placed in 80 ℃ of water baths, heated and melted, and Add the mixed surfactant into the isopropyl palmitate, stir, dissolve evenly, and cool;

[0015] The mixed surfactant is a composition of a surfactant and a co-surfactant at a mass ratio of 4:1;

[0016] The surfactant is composed of Tween 80 and polyoxyethylene hydrogenated castor oil, the mass ratio of the two is, Tween 80:polyoxyethylene hydrogenated castor oil=2:1;

[0017] Co-surfactant is absolute ethanol.

Embodiment 3

[0018] Embodiment 3: oil-in-water nanoemulsion matrix, including isopropyl palmitate 30% and mixed surfactant 70% by mass percentage; Isopropyl palmitate is placed in 80 ℃ of water baths, heated and melted, and Add the mixed surfactant into the isopropyl palmitate, stir, dissolve evenly, and cool;

[0019] The mixed surfactant is a composition of a surfactant and a co-surfactant at a mass ratio of 4:1;

[0020] The surfactant is composed of Tween 80 and polyoxyethylene hydrogenated castor oil, the mass ratio of the two is, Tween 80:polyoxyethylene hydrogenated castor oil=3:1;

[0021] The co-surfactant is polyethylene glycol 400.

[0022] The relevant test data of the nanoemulsion matrix made by the inventive method are as follows:

[0023] (1) Tyndall phenomenon

[0024] The nanoemulsion will show Tyndall phenomenon under the irradiation of converging light, so as to check whether the prepared matrix is ​​a nanoemulsion. Take 1 g of nanoemulsion matrix prepared by the met...

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Abstract

The invention aims to provide an oil-in-water type nano emulsion matrix. According to a technical scheme, the oil-in-water type nano emulsion matrix comprises the following components in percentage by mass: 10 to 30 percent of isopropyl palmitate, and 70 to 90 percent of a mixed surfactant; the isopropyl palmitate is placed in a water bath of 80 DEG C, and is heated and molten; the mixed surfactant is added into the isopropyl palmitate, is stirred and dissolved uniformly, and is cooled; the mixed surfactant is a composition which comprises a surfactant and a cosurfactant in the mass ratio of 4:1; the surfactant consists of Tween 80 and polyoxyethylene hydrogenated castor oil in the mass ratio of (2-3):1; the cosurfactant is one of glycerol, absolute ethyl alcohol and polyethylene glycol 400. The oil-in-water type nano emulsion matrix provided by the invention is reasonable in formula, high in stability, simple in producing process, convenient to produce and wide in application range, does not have stimulus and has a certain economic and social significance.

Description

technical field [0001] The invention relates to medicine, in particular to an oil-in-water nanoemulsion matrix. Background technique [0002] Nanoemulsions are clear isotropic solutions of oils, surfactants and co-surfactants. This system can spontaneously form a transparent or translucent liquid drug-loading system with a particle size of 10-100nm in gastrointestinal fluid, water and other media with slight stirring. The milk droplets are mostly spherical and relatively uniform in size. Like ordinary emulsions, nanoemulsions can be divided into oil-in-water type (O / W), water-in-oil type (W / O) and bicontinuous type from the structure. The drug is present in these tiny oil droplets, which can be quickly absorbed by the skin, thereby reducing the irritation caused by large amounts of drugs in contact with the skin for a long time. Nanoemulsion has the functions of promoting penetration, sustained release and reducing the irritation and side effects of drugs. Nanoemulsions ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/14A61K47/26A61K47/44A61K47/10
CPCA61K9/1075A61K47/10A61K47/14A61K47/26A61K47/44
Inventor 魏玉许海涛沈继朵郭燕
Owner HENAN UNIV OF CHINESE MEDICINE
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