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A kind of preparation method of traditional Chinese medicine preparation for heart failure treatment
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A technology of preparations and traditional Chinese medicine capsules, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of inconvenient use for patients, poor stability of decoctions, and unfavorable ginseng and heart benefits. Problems such as prescription promotion and clinical application to achieve the effect of improving stability
Active Publication Date: 2018-05-18
HEILONGJIANG UNIV OF CHINESE MEDICINE
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[0005] Although Shenqi Yixin Decoction has achieved excellent clinical efficacy, it is inconvenient for patients to use because it is a traditional Chinese medicine decoction, and the stability of the decoction is not good, which is not conducive to the promotion and clinical practice of Shenqi Yixin Decoction. application
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Embodiment 1
[0016] The preparation of embodiment 1 Chinese medicine capsule
[0017] (1) Weigh 20g of Radix Astragali, 10g of Guizhi, 15g of Epimedium, 20g of Poria, 15g of Tinglizi, 15g of Atractylodes Rhizome, 15g of Motherwort, 30g of Agrimony and 10g of Licorice; Double the amount and 8 times the amount of water for reflux extraction three times, the extraction time is 2 hours each time, filter and combine the filtrates, recover under reduced pressure to obtain the extract 1;
[0018] (2) Weigh 15 g of Salvia miltiorrhiza and use 10 times, 10 times and 8 times of 80% ethanol to extract at 80° C. for 2 hours, and recover under reduced pressure to obtain extract 2;
[0019] (3) Weigh 20 g of Radix Pseudostellariae, grind it into fine powder and pass through a 200-mesh sieve; take extract 1 and extractum 2 and vacuum-dry to obtain dry powder, mix well, and mix the fine powder of Radix Pseudostellariae and the dry powder of extract with corresponding weight parts of microcrystalline Cell...
Embodiment 2
[0020] Embodiment 2 Chinese medicine capsule stability investigation
[0021] According to the stability guidelines of the second appendix of the Chinese Pharmacopoeia 2010 edition, the stability of the relevant samples was investigated, and the stability of the drug was investigated at 25°C for 36 months, 45°C and 75% relative humidity for 120 days. The content of astragaloside IV and salvianolic acid B in traditional Chinese medicine capsules was determined by HPLC.
[0022] Contents of active ingredients of traditional Chinese medicine in each group after being stored at 25°C for 36 months (n=10)
[0023]
[0024]
Embodiment 3
[0031] Embodiment 3 Chinese medicine capsule preparation content granule angle of repose is measured
[0032] The fixed funnel method (the third edition of "Pharmaceutical Science" edited by Xi Nianzhu) was used to measure the angle of repose of the granules before filling the sample, and the difference in the filling volume of the sample was determined according to the relevant regulations under Appendix II L of the Chinese Pharmacopoeia 2010 Edition.
[0033]
[0034]
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Abstract
The invention relates to a preparation method of a traditional Chinese medicinal preparation for treating heart failure, belonging to the field of traditional Chinese medicines. The preparation method comprises the following specific steps: (1) weighing radix astragali, ramulus cinnamomi, herba epimedii, poria cocos, semen lepidii, white atractylodes rhizome, herba leonuri, herba agrimoniae and licorice root, smashing the above medicinal materials at a certain ratio, carrying out three times of reflux extraction by adopting 8-10-fold water, 8-10-fold water and 8-10-fold water respectively, wherein the extraction time for each time is 2h, filtering the extracting solutions, mixing the filtrates, and carrying out vacuum recycling for obtaining extract I; (2) weighing 15g of radix salviae miltiorrhizae, carrying out extraction by adopting 10-fold 80% of alcohol, 10-fold 80% of alcohol and 8-fold 80% of alcohol at 80 DEG C, the extraction time is 2h, and carrying out vacuum recycling for obtaining extract II; (3) weighing 20g of radix pseudostellariae, grinding the radix pseudostellariae into fine powder, screening the fine powder by a 200-mesh sieve, carrying out vacuum drying on the extract I and the extract II, thus obtaining dry powder, uniformly mixing the dry powder, mixing the radix pseudostellariae fine powder and the extract dry powder to obtain a traditional Chinese medicinal composition, mixing the traditional Chinese medicinal composition with auxiliary materials with the corresponding weight parts, adding with an appropriate amount of 60% of alcohol, carrying out pelleting, carrying out drying, and filling blank capsules with the pellets, thus obtaining the traditional Chinese medicinal preparation.
Description
technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation for treating heart failure, belonging to the field of traditional Chinese medicines. Background technique [0002] Heart failure is a complex clinical syndrome of impaired ventricular filling or ejection due to any structural or functional abnormality of the heart, characterized clinically by dyspnea and limited activity tolerance, as well as fluid retention (pulmonary congestion and peripheral edema) . Heart failure is the severe and terminal stage of various heart diseases, with a high incidence rate, and is one of the most important cardiovascular diseases today. [0003] Heart failure is a disease name in modern medicine based on pathophysiological changes. There is no such name in traditional Chinese medicine literature, but according to its clinical manifestations and characteristics, there are many descriptions and explorations of heart failure in the th...
Claims
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Application Information
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