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Chinese medicinal preparation for chronic heart failure

A technology of preparation and traditional Chinese medicine, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and medical formulas, etc., which can solve the problems of inconvenient use for patients, poor stability of decoctions, unfavorable promotion and clinical application of Shenqi Yixin Fang, etc. problem, to achieve the effect of improving stability

Inactive Publication Date: 2016-10-12
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although Shenqi Yixin Decoction has achieved excellent clinical efficacy, it is inconvenient for patients to use because it is a traditional Chinese medicine decoction, and the stability of the decoction is not good, which is not conducive to the promotion and clinical practice of Shenqi Yixin Decoction. application

Method used

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  • Chinese medicinal preparation for chronic heart failure
  • Chinese medicinal preparation for chronic heart failure
  • Chinese medicinal preparation for chronic heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 Chinese medicine capsule

[0015] (1) Weigh 20g of Radix Astragali, 10g of Guizhi, 15g of Epimedium, 20g of Poria, 15g of Tinglizi, 15g of Atractylodes Rhizome, 15g of Motherwort, 30g of Agrimony and 10g of Licorice; Double the amount and 8 times the amount of water for reflux extraction three times, the extraction time is 2 hours each time, filter and combine the filtrates, recover under reduced pressure to obtain the extract 1;

[0016] Weigh 15g of Salvia miltiorrhiza and use 10 times, 10 times and 8 times the amount of 80% ethanol to extract at 80°C for 2 hours, and recover under reduced pressure to obtain extract 2;

[0017] (3) Weigh 20 g of Radix Pseudostellariae, grind it into fine powder and pass through a 200-mesh sieve; take extract 1 and extractum 2 and vacuum-dry to obtain dry powder, mix well, and mix the fine powder of Radix Pseudostellariae and the dry powder of extract with corresponding weight parts of microcrystalline ...

Embodiment 2

[0018] Embodiment 2 Chinese medicine capsule stability investigation

[0019] According to the stability guidelines of the second appendix of the Chinese Pharmacopoeia 2010 edition, the stability of the relevant samples was investigated, and the stability of the drug was investigated at 25°C for 36 months, at 45°C and at a relative humidity of 75% for 120 days. The content of astragaloside IV and salvianolic acid B in traditional Chinese medicine capsules was determined by HPLC.

[0020] Contents of active ingredients of traditional Chinese medicine in each group after being stored at 25°C for 36 months (n=10)

[0021]

[0022]

Embodiment 3

[0030] Embodiment 3 Chinese medicine capsule preparation content granule angle of repose is measured

[0031] The fixed funnel method (the third edition of "Pharmaceutical Science" edited by Xi Nianzhu) was used to measure the angle of repose of the granules before filling the sample, and the difference in the filling volume of the sample was determined according to the relevant regulations under Appendix II L of the Chinese Pharmacopoeia 2010 Edition.

[0032]

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Abstract

Belonging to the field of traditional Chinese medicines, the invention relates to a Chinese medicinal composition for chronic heart failure and a related preparation thereof. The preparation is composed of the Chinese medicinal composition and auxiliary materials in a weight ratio of 10:0.2-1.1. The Chinese medicinal composition is preferably prepared from the following Chinese herbal medicines by weight: 20 parts of radix astragali, 20 parts of radix pseudostellariae, 10 parts of cassia twig, 15 parts of herba epimedii, 20 parts of Poria cocos, 15 parts of Semen Lepidii, 15 parts of bighead atractylodes rhizome, 15 parts of Salvia Miltiorrhiza, 15 parts of motherwort, 30 parts of hairyvein agrimony, and 10 parts of licorice.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for chronic heart failure and related preparations, belonging to the field of traditional Chinese medicines. Background technique [0002] Heart failure is a complex clinical syndrome of impaired ventricular filling or ejection due to any structural or functional abnormality of the heart, characterized clinically by dyspnea and limited activity tolerance, as well as fluid retention (pulmonary congestion and peripheral edema) . Heart failure is the severe and terminal stage of various heart diseases, with a high incidence rate, and is one of the most important cardiovascular diseases today. [0003] Heart failure is a disease name in modern medicine based on pathophysiological changes. There is no such name in traditional Chinese medicine literature, but according to its clinical manifestations and characteristics, there are many descriptions and explorations of heart failure in the th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/48A61P9/04
CPCA61K9/1652A61K36/076A61K36/284A61K36/296A61K36/31A61K36/36A61K36/481A61K36/484A61K36/533A61K36/537A61K36/54A61K36/73A61K2300/00
Inventor 吴伦吴丽红卞敬琦刘莉谢宁田振坤
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE