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A kind of traditional Chinese medicine granule for treating women's dysmenorrhea and preparation method thereof

A technology of traditional Chinese medicine granules and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc. It can solve the problems of reducing dosage, instability of granules, and inability to completely overcome the hygroscopicity of granules. The effect of improving stability

Active Publication Date: 2016-03-02
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent CN1548125 discloses an improved dosage form of women's dysmenorrhea pills, which improves the stability of the drug to a certain extent and reduces the dosage by changing the pills into granules. Hygroscopicity issues, resulting in instability of granules

Method used

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  • A kind of traditional Chinese medicine granule for treating women's dysmenorrhea and preparation method thereof
  • A kind of traditional Chinese medicine granule for treating women's dysmenorrhea and preparation method thereof
  • A kind of traditional Chinese medicine granule for treating women's dysmenorrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 1000g Corydalis Corydalis, 1000g Wulingzhi, 1000g Salvia Miltiorrhiza and 1000g Puhuang, extract with 1.5L of 80% ethanol at 80°C for 2 hours, filter, add 1.2L of 80% ethanol and extract at 80°C for 2 hours, filter and combine the filtrates, Recover the extract with a relative density of 1.25-1.30 (50°C), add 1.2L of water to the filter residue to extract for 2 hours, filter, recover under reduced pressure to obtain an extract with a relative density of 1.25-1.30 (50°C), combine the extracts, and take 300g Mix the extract and 30g of auxiliary materials (the weight ratio of hydroxypropyl methylcellulose, pregelatinized starch and aspartame in the auxiliary materials is 1:0.2:0.02), add an appropriate amount of 60% ethanol to granulate, and dry to obtain.

Embodiment 2-5

[0017] Except the following table parameter, other preparation methods are all identical with embodiment 1

[0018]

[0019]

[0020] The stability investigation of the women's dysmenorrhea granule prepared in embodiment 6 embodiment 1-3

[0021] According to the stability guidelines of the second appendix of the Chinese Pharmacopoeia 2010 edition, the stability of the relevant samples was investigated, and the stability of the drug was investigated at 25°C for 36 months, and at 25°C and a relative humidity of 75% for 60 days. The contents of tetrahydropalmatine and salvianolic acid B in traditional Chinese medicine granules were determined by HPLC.

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for treating women's primary dysmenorrhea and a preparation method thereof. It consists of traditional Chinese medicine extracts and auxiliary materials. The weight ratio of the traditional Chinese medicine extract to auxiliary materials is 10:1.0-1.6; the traditional Chinese medicine extract is made of 10 parts by weight of Corydalis Corydalis, 10 parts of Salvia Miltiorrhiza, 10 parts of Wulingzhi and 10 parts of Puhuang. The auxiliary material is preferably hydroxypropyl methylcellulose, pregelatinized starch and aspartame, and the weight ratio of the three is 1:0.2-0.8:0.02. The present invention has obtained the optimal scheme of the types, proportions and dosages of auxiliary materials through a large number of experimental studies. The use of the above-mentioned auxiliary materials can overcome the problem that the traditional Chinese medicine granules affect the drug stability due to hygroscopicity. The traditional Chinese medicine granules of the present invention greatly improve women's Stability of Tongjing Granules.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound traditional Chinese medicine preparation for treating women's primary dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to a gynecological disease in which women experience periodic lower abdominal pain during or before and after menstruation, accompanied by other discomforts, which affect work and life. The incidence rate of dysmenorrhea among women in my country is 33.19%, which is a common and frequently-occurring disease in gynecology. Dysmenorrhea is divided into two types: primary and secondary. Primary dysmenorrhea refers to dysmenorrhea without organic lesions in the genitals, and it mostly occurs in adolescence. Its pathological mechanism may be related to prostaglandins in the endometrium, and the content of prostaglandins in the endometrium and blood of dysmenorrhea patients is higher th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61K9/16A61P15/00A61K35/24
CPCA61K9/1652A61K35/24A61K36/537A61K36/66A61K36/88A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 肖军平吴永忠康兴东杨伟庆陈金德
Owner JIANGXI POZIN PHARMA