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Application of rudbeckia laciniata in preparation of xanthine oxidase inhibitor

A technology of xanthine oxidase and coneflower, applied in the application, anti-inflammatory agent, function of food ingredients, etc., can solve problems such as elevated blood uric acid

Inactive Publication Date: 2016-11-23
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides an application of coneflower double petals in the preparation of xanthine oxidase inhibitors to solve the problem of abnormally elevated blood uric acid in hyperuricemia, gout and other related diseases

Method used

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  • Application of rudbeckia laciniata in preparation of xanthine oxidase inhibitor
  • Application of rudbeckia laciniata in preparation of xanthine oxidase inhibitor
  • Application of rudbeckia laciniata in preparation of xanthine oxidase inhibitor

Examples

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Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Acute toxicity test

[0018] Due to the limitation of administration concentration and administration volume, the LD50 of intragastric administration in mice could not be measured. The mice were administered by gavage at a dose of kg, and the animals were in good condition and no acute toxic reaction was observed. 140.5g / kg, 160.0g / kg, 165.0g / kg).

Embodiment 2

[0019] Embodiment 2: the application of double-flowered coneflower to prepare uric acid-lowering products

[0020] 1. Rudbeckia laciniata capsule (RLC): collect Rudbeckia rudbeckia laciniata, dry in the shade, pulverize, and prepare a hard capsule preparation.

[0021] 2. Rudbeckia laciniata tablet (RLT): collect Rudbeckia laciniata tablet, dry in the shade, pulverize, ultrasonically extract three times with 10 times the volume of 75% ethanol for 30 minutes each time, filter, combine the filtrates, and evaporate to dryness , crushed, add appropriate amount of starch, tablet.

[0022] 3. Rudbeckia laciniata oral liquid (RLOL): take Rudbeckia laciniata oral liquid, decocted with 10 times the amount of water for 40 minutes, filter, concentrate the filtrate to obtain a liquid extract, add accessories to make an oral liquid .

Embodiment 3

[0023] Embodiment 3: Study on the activity of uric acid-lowering products of golden light chrysanthemum

[0024] 1 material

[0025] 1.1 Medicinal materials and reagents

[0026] Rudbeckia laciniata was collected from Linjiang area of ​​Changbai Mountains, xanthine (XA) and xanthine oxidase (XOD) were purchased from Sigma Company in the United States; allopurinol was purchased from Shanghai Aladdin Reagent Co., Ltd. ; Other reagents are of domestic analytical grade.

[0027] 1.2 Instruments

[0028] Thermo Multiskan GO full-wavelength microplate reader (Thermo Fisher Scientific); ABS 320-4N analytical balance (Shanghai Daohan Industrial Co., Ltd.); KQ-250B CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.) ; RE-52AA Rotary Evaporator (Shanghai Yarong Biochemical Instrument Factory); DZF6020 Vacuum Dryer (Shanghai Yiheng Scientific Instrument Co., Ltd.).

[0029] 2 methods

[0030] Xanthine Oxidase Inhibitory Activity of Phenolic Acids and Flavonoids in Honey...

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Abstract

The invention relates to application of rudbeckia laciniata in preparation of a xanthine oxidase inhibitor, and belongs to the field of traditional Chinese medicines. The invention also relates to application of rudbeckia laciniata and extracts thereof serving as active ingredients in preparation of the xanthine oxidase inhibitor, wherein the rudbeckia laciniata and extract thereof comprise rudbeckia laciniata thallus and solvent extracts thereof; and the solvent extracts are extracts of water, ethanol and methanol. The invention has the beneficial effects that the problem of abnormal rise of blood uric acid caused by related diseases such as hyperuricemia, gout and the like is solved, and related symptoms of diseases such as arthralgia, swelling deformation, hypertension, diabetes, cardiovascular disease, kidney diseases, metabolic syndrome and the like caused by the diseases such as hyperuricemia, gout and the like are indirectly solved and relieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine source xanthine oxidase inhibitor. Background technique [0002] Sustained high levels of uric acid in the body will cause sodium urate crystals to deposit in joints and surrounding tissues, resulting in a purine metabolic disease - gout. Hyperuricemia is an important sign of gout, about 5% to 12% of hyperuricemia will eventually develop into gout, and 80% to 90% of gout patients are accompanied by hyperuricemia. In addition, hyperuricemia is also closely related to the occurrence of hypertension, diabetes, cardiovascular disease, kidney disease, metabolic syndrome and other diseases. The incidence of gout varies greatly from region to region. The incidence of gout is only 0.03% in Nigeria, while the incidence of gout is as high as 15.2% in the indigenous population of Taiwan. Epidemiological surveys show that due to the improvement of ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P19/06A61P19/02A61P29/00A61P9/12A61P3/10A61P9/00A61P13/12A61P3/00A23L33/105A23L33/10
CPCA61K36/28A23V2002/00A23V2200/30A23V2250/21
Inventor 李海军涂正坤翟乃翠刘菲高永梅
Owner JILIN UNIV
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