Application of geum aleppicum in preparation of xanthine oxidase inhibitor

A technology of xanthine oxidase and herbal salicyme, which is applied in the fields of application, function of food ingredients, medical preparations containing active ingredients, etc., can solve problems such as elevated blood uric acid

Inactive Publication Date: 2016-10-26
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides an application of the herb Salicyrbutus in the preparation of xanthine oxidase inhibitors to solve the problem of abnormally elevated blood uric acid in hyperuricemia, gout and other related diseases

Method used

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  • Application of geum aleppicum in preparation of xanthine oxidase inhibitor
  • Application of geum aleppicum in preparation of xanthine oxidase inhibitor
  • Application of geum aleppicum in preparation of xanthine oxidase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Application of the herb Myrica rubra to prepare uric acid-lowering products

[0018] 1. Herbal Geum aleppicum capsule (GAC): take the herbal Geum aleppicum capsule, dry it in the shade, crush it, and make a hard capsule preparation.

[0019] 2. Herbal Geum aleppicum tablet (GAT): Collect the herbal Geum aleppicum, dry in the shade, crush, ultrasonically extract three times with 10 times the amount of 75% ethanol, 30 minutes each time, filter, combine the filtrates, evaporate to dryness, and crush , add appropriate amount of starch, and press into tablets.

[0020] 3. Herbal Geum aleppicum oral liquid (Geum aleppicum oral liquid, GAOL): Take the herbal Geum aleppicum oral liquid, decoct in 10 times the amount of water for 40 minutes, filter, concentrate the filtrate to obtain a liquid extract, add auxiliary materials, and make an oral liquid.

Embodiment 2

[0021] Example 2: Study on the activity of the herbal uric acid-lowering product of Myrica rubra

[0022] 1 material

[0023] 1.1 Medicinal materials and reagents

[0024] The herbal water bayberry Rudbeckia laciniata is collected from the Linjiang area of ​​the Changbai Mountains. Xanthine (XA) and xanthine oxidase (XOD) were purchased from Sigma, USA; allopurinol was purchased from Shanghai Aladdin Reagent Company; other reagents were domestic analytical grade.

[0025] 1.2 Instruments

[0026] Thermo Multiskan GO full-wavelength microplate reader (Thermo Fisher Scientific); ABS 320-4N analytical balance (Shanghai Daohan Industrial Co., Ltd.); KQ-250B CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.) ; RE-52AA rotary evaporator (Shanghai Yarong Biochemical Instrument Factory); DZF6020 vacuum dryer (Shanghai Yiheng Scientific Instrument Co., Ltd.).

[0027] 2 methods

[0028] Xanthine oxidase inhibitory activity of phenolic acids and flavonoids in honeysuc...

Embodiment 3

[0048] Embodiment 3: the preparation of the uric acid-lowering food of herbal red bayberry

[0049] 1. Herbal water bayberry teabag: Collect fresh herbal water bayberry, dry in the shade, crush, pass through a 40-mesh sieve, 24-mesh sieve, sterilize with ultraviolet light, mechanically bag, pack, print the date, plastic seal, and store.

[0050] 2. Herbal water bayberry drink: take herbal water bayberry, 10 times the amount of ultrasonic treatment for 20 minutes, filter, add benzoic acid, sodium benzoate and other preservatives to the filtrate, add flavoring agent to taste, sterilize, fill, print the date, pack into library.

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Abstract

The invention relates to application of geum aleppicum in preparation of a xanthine oxidase inhibitor, and belongs to the field of traditional Chinese medicines. Application of geum aleppicum and extracts thereof as active ingredients in the preparation of the xanthine oxidase inhibitor is provided, wherein the geum aleppicum and extracts thereof comprise geum aleppicum original plants and solvent extracts thereof, and the solvent extracts are water, ethanol, and methanol extracts. The application of the geum aleppicum in the preparation of the xanthine oxidase inhibitor has the beneficial effects that: a problem of abnormal increasing of blood uric acid caused by diseases, such as hyperuricemia, gout and the like is solved, and related symptoms of diseases, such as arthralgia, swelling deformation, hypertension, diabetes mellitus, cardiovascular diseases, metabolic syndrome and the like, and caused by the diseases, such as the hyperuricemia, gout and the like, is indirectly solved and remitted.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a xanthine oxidase inhibitor derived from traditional Chinese medicine. Background technique [0002] If the uric acid level in the body continues to be high and supersaturated, sodium urate crystals will be deposited in the joints and surrounding tissues, resulting in gout, a purine metabolic disease. Hyperuricemia is an important sign of gout. About 5% to 12% of hyperuricemia will eventually develop into gout, and 80% to 90% of gout patients are accompanied by hyperuricemia. In addition, hyperuricemia is also closely related to the occurrence of hypertension, diabetes, cardiovascular disease, kidney disease, metabolic syndrome and other diseases. The incidence of gout varies greatly between regions. Its incidence is only 0.03% in Nigeria, but as high as 15.2% among the aborigines of Taiwan. Epidemiological surveys show that due to the improvement of people's living...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P19/06A61P3/10A61P9/12A61P9/00A61P13/12A61P3/00A23L33/10A23L33/105
CPCA61K36/73A23V2002/00A23V2200/30A23V2200/326A23V2200/328A23V2250/21
Inventor 李海军刘菲涂正坤翟乃翠高永梅
Owner JILIN UNIV
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