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Application of chokeberry to preparation of xanthine oxidase inhibitor

A technology of xanthine oxidase and rowan fruit, which can be used in application, anti-inflammatory agent, function of food ingredients, etc., can solve problems such as elevated blood uric acid

Inactive Publication Date: 2016-12-07
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides an application of rowan fruit in the preparation of xanthine oxidase inhibitors to solve the problem of abnormally elevated blood uric acid in hyperuricemia, gout and other related diseases

Method used

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  • Application of chokeberry to preparation of xanthine oxidase inhibitor
  • Application of chokeberry to preparation of xanthine oxidase inhibitor
  • Application of chokeberry to preparation of xanthine oxidase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the application of uric acid-lowering product prepared by Rowan fruit

[0018] 1. Sorbus pohuashanensis capsule (SPC): Sorbus pohuashanensis capsules are collected, dried in the shade, crushed, and made into hard capsule preparations.

[0019] 2. Sorbus pohuashanensis tablet (SPT): Collect the Sorbus pohuashanensis tablet, dry in the shade, crush, ultrasonically extract three times with 10 times the amount of 75% ethanol, 30 minutes each time, filter, combine the filtrates, evaporate to dryness, and crush , add appropriate amount of starch, and press into tablets.

[0020] 3. Sorbus pohuashanensis oral liquid (SPOL): take Sorbus pohuashanensis oral liquid, decoct 10 times the amount of water for 40 minutes, filter, concentrate the filtrate to obtain a liquid extract, add auxiliary materials, and make an oral liquid.

Embodiment 2

[0021] Example 2: Research on the activity of uric acid-lowering products of Rowan fruit

[0022] 1 material

[0023] 1.1 Medicinal materials and reagents

[0024] Sorbus fruit, the fruit of Sorbus pohuashanensis, a plant of the Rosaceae Sorbus family, is collected from the Linjiang area of ​​the Changbai Mountains. Xanthine (XA) and xanthine oxidase (XOD) were purchased from Sigma, USA; allopurinol was purchased from Shanghai Aladdin Reagent Company; other reagents were domestic analytical grade.

[0025] 1.2 Instruments

[0026] Thermo Multiskan GO full-wavelength microplate reader (Thermo Fisher Scientific); ABS 320-4N analytical balance (Shanghai Daohan Industrial Co., Ltd.); KQ-250B CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.) ; RE-52AA rotary evaporator (Shanghai Yarong Biochemical Instrument Factory); DZF6020 vacuum dryer (Shanghai Yiheng Scientific Instrument Co., Ltd.).

[0027] 2 methods

[0028] Xanthine oxidase inhibitory activity of phenol...

Embodiment 3

[0048] Embodiment 3: the preparation of uric acid-lowering food of rowan fruit

[0049] 1 Rowan fruit tea bag: collect fresh rowan fruit, dry in the shade, crush, pass through 40-mesh sieve, 24-mesh sieve, sterilize with ultraviolet light, mechanically bag, pack, print the date, plastic seal, and store.

[0050] 2 Rowan Beverage: Take Rowan Berry, 10 times the amount of ultrasonic treatment for 20 minutes, filter, add preservatives such as benzoic acid and sodium benzoate to the filtrate, add flavoring agent to taste, sterilize, fill, spray date, pack and store .

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PUM

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Abstract

The invention relates to application of chokeberry to preparation of a xanthine oxidase inhibitor and belongs to the field of traditional Chinese medicine. Chokeberry and extracts of the chokeberry serve as active components and are used for preparing the xanthine oxidase inhibitor. The chokeberry and extracts of the chokeberry include chokeberry original plants and solvent extracts, and the solvent extracts include water, ethyl alcohol and methyl alcohol extracts. The application has the advantages that the problem that blood uric acid of hyperuricemia, gout and related diseases abnormally increases is solved, joint pain, swelling and deformation caused by hyperuricemia, gout and related diseases are indirectly relieved, and relevant symptoms of diseases like hypertension, diabetes, cardiovascular diseases, kidney diseases and metabolic syndromes are relieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a xanthine oxidase inhibitor derived from traditional Chinese medicine. Background technique [0002] If the uric acid level in the body continues to be high and supersaturated, sodium urate crystals will be deposited in the joints and surrounding tissues, resulting in gout, a purine metabolic disease. Hyperuricemia is an important sign of gout. About 5% to 12% of hyperuricemia will eventually develop into gout, and 80% to 90% of gout patients are accompanied by hyperuricemia. In addition, hyperuricemia is also closely related to the occurrence of hypertension, diabetes, cardiovascular disease, kidney disease, metabolic syndrome and other diseases. The incidence of gout varies greatly between regions. Its incidence is only 0.03% in Nigeria, but as high as 15.2% among the aborigines of Taiwan. Epidemiological surveys show that due to the improvement of people's living...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P19/06A61P29/00A61P9/12A61P3/10A61P9/00A61P13/12A61P3/00A23L33/105
CPCA61K36/73A23V2002/00A23V2200/30A23V2250/21
Inventor 李海军涂正坤翟乃翠刘菲高永梅
Owner JILIN UNIV
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