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Medicinal composition for preventing and treating diabetes

A composition and technology for diabetes, applied in drug combination, metabolic disease, pharmaceutical formula, etc., can solve the problems of diabetic patients with elevated blood sugar, not given the method of using Morus alba and mulberry, and unfavorable to the health of patients

Inactive Publication Date: 2017-01-04
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although it has been shown in the above prior art that Cortex Morus alba and Mulberry may have hypoglycemic effects respectively, the prior art does not provide the method of using Cortex Morus alba and Mulberry
Especially because mulberry is rich in fructose, if the mechanism and specific active ingredients are not clear, the rich fructose will cause a sharp increase in the blood sugar of diabetic patients, which is not conducive to the health of patients
Furthermore, ebony is rich in citric acid, malic acid, and succinic acid. Eating too much will not only damage the teeth, but also damage the spleen and stomach.

Method used

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  • Medicinal composition for preventing and treating diabetes
  • Medicinal composition for preventing and treating diabetes
  • Medicinal composition for preventing and treating diabetes

Examples

Experimental program
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Effect test

preparation example Construction

[0024] 2. Preparation of the composition

[0025] The above-mentioned volatile oils separated and collected from mulberry and mulberry bark are mixed according to a specific ratio to prepare a composition stock solution. According to different clinical needs, it can be made into pills, powders, tablets, suppositories, granules, films, capsules, microcapsules, dripping pills, aerosols, injections, ointments, alcohol, syrups, and oral Solution, gel or liposome.

[0026] The specific implementation mode can be implemented in accordance with the standards of the Chinese Pharmacopoeia 2000 edition.

[0027] 3. Effect detection of the composition of the present invention

[0028] 3.1 Animal source and model preparation

[0029] Healthy male SD rats, 2 months old, weighing 150-200g, were provided by Zhejiang Laboratory Animal Center. Before the experiment, the animals were placed in the laboratory to adapt to the environment for one week, free drinking water and standard rat feed, keeping t...

Embodiment

[0055] Separately mix 1000g fresh fruits (or frozen fresh fruits) of mulberry and ebony with a blender to homogenize them, and place them as figure 1 In the distillation flask shown, the distillation product is collected after distillation. Among them, the distillation product of mulberry was 452 g, and the yield was 45.2%, and the distillation product of ebony plum was 337 g, and the yield was 33.7%.

[0056] The above-mentioned distilled products were formulated in different proportions and fed to model rats and normal rats as controls. Specific experimental examples and comparison examples are shown in Table 1. After the four-week feeding experiment, the blood index values ​​of the rats in each group were counted, and the serum glucose concentration (unit: mg / dl) was determined by the glucose oxidase method.

[0057] figure 2 Shown are the results of a typical experimental example of the composition of the present invention, each experimental group is the average of three repea...

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Abstract

The invention discloses a medicinal composition for preventing and treating diabetes. The medicinal composition contains 60 to 85 percent by weight of white mulberry root-bark and 7 to 11 percent by weight of mulberry serving as effective components. As proved by animal experiments, the medicinal composition for preventing and treating diabetes in an intervening way can effectively lower the blood glucose levels of diabetic rats, and reduce the glucose tolerance experimental area under curve.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating diabetes, in particular to a pharmaceutical composition for intervention and treatment of diabetes containing mulberry and mulberry bark as effective ingredients. Background technique [0002] Diabetes is a series of metabolic disorder syndromes such as sugar, protein, fat, water and electrolytes caused by a variety of pathogenic factors acting on the body, leading to hypofunction of islets and insulin resistance. It is clinically characterized by high blood sugar. The overall prevalence of diabetes in my country has reached 9.7%. During the same period, the prevalence of prediabetes was as high as 15.5%. The calculation based on the survey results shows that the total number of diabetic patients in my country is more than 92 million, and the number of pre-diabetes is more than 148 million. Diabetes is the absolute or relative lack of insulin secretion by pancreatic β cells,...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P3/10
Inventor 步世忠刘琼赖晓龙袁燕燕刘冰洋
Owner NINGBO UNIV
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