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Method for extracting salicin from cortex salicis and obtained extract

A technology of salicin and extract, which is applied in the field of medicine, can solve the problems of low yield and achieve the effect of increasing yield

Inactive Publication Date: 2017-01-04
三原金瑞生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The first object of the present invention is to provide a method for extracting salicin from willow bark, which solves the problem of low yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. First, clean the screened white willow stems, stems and leaves, soak them in 18-20 times pure water in the cleaning tank for several times, stir for 10 minutes every half hour, and transport the cleaned white willow raw materials to the crushing equipment. The crushing equipment performs different crushing processes according to different parts of the white willow, and obtains about 1000g of willow bark raw material.

[0031] 2. The second step is to crush the cleaned raw materials. After the crushing is completed, the effective extraction part flows into the extraction tank to obtain about 1000g willow bark raw materials. The waste residue is removed through special pipelines.

[0032] 3. Stir the pulverized matter with 50 grams of quicklime, mix well, and let it stand for four hours.

[0033] 4. Soak in 3000mL alcoholic water (85% ethanol) for one hour, then heat to near boiling (close to 70°C), soak for three hours, and drain.

[0034] 5. Add 1000 milliliters of ...

Embodiment 2

[0054] The difference with Example 1 is that when the 8th step column layer is separated, obtain content between 5% to 15% extract, this extract is processed as follows:

[0055] After standing still for 72 hours, the product naturally crystallized and formed a precipitate. The product is centrifuged to obtain a solid content of 70% and a mother liquor of 10%.

[0056] 70% of the solids were washed three times with anhydrous petroleum ether on high-purity vacuum filtration equipment, filtered, and then washed three times with anhydrous ether, filtered to obtain 10% mother liquor and high-purity decolorized pure white solids.

[0057]The pure white solid was vacuum-dried, and the content was detected by HPLC. The salicin content was 99.4%, the ash content was 1%, and the moisture content was 0.9%.

Embodiment 3

[0059] The difference from Example 1 is only that the amount of quicklime added in the first step is different, which is 100g.

[0060] Detection:

[0061] All the extract products are summed up, and the salicin extraction amount after conversion is 9.8g, and other indicators are the same as in Example 1.

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PUM

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Abstract

The invention provides a method for extracting salicin from cortex salicis and an obtained extract. According to the method for extracting the salicin from the cortex salicis, before extraction, the cortex salicis serving as a raw material and quick lime are mixed and stacked according to a weight ratio of (10 to 25):1. The method provided by the invention solves the problem of low yield.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for extracting salicin from willow bark and the obtained extract. Background technique [0002] Aspirin, also known as compound acetylsalicylic acid tablets (apc), has good analgesic, anti-inflammatory, antipyretic, anti-rheumatic, and inhibitory effects on platelet aggregation. At present, aspirin medicines on the market are usually prepared by using salicylic acid and acetic anhydride under the catalytic reaction of corresponding reagents, or extracting the pure natural active substance salicin from plants. The former is a synthetic substitute for salicin, which has potentially dangerous side effects on the gastrointestinal tract. Salicin, in its natural form, passes harmlessly through the gastrointestinal system and is converted to salicylic acid in the blood and liver. The conversion takes several hours, so the results are not immediately felt by the body, but the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H15/203
CPCC07H1/08C07H15/203
Inventor 王轩张楠
Owner 三原金瑞生物工程有限公司
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