Method for quickly detecting volatile N-nitrosamine in cosmetics

A detection method and volatility technology, which is applied in the field of rapid sample processing and detection of volatile N-nitrosamines, can solve problems such as high detection limit and interference, and achieve high accuracy, low cost, and simple pretreatment Effect

Inactive Publication Date: 2017-01-11
ANHUI YIKANGDA PHOTOELECTRIC TECH CO LTD +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the method commonly used in GB/T29669-2013 is gas chromatography-mass spectrometry, but

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  • Method for quickly detecting volatile N-nitrosamine in cosmetics
  • Method for quickly detecting volatile N-nitrosamine in cosmetics
  • Method for quickly detecting volatile N-nitrosamine in cosmetics

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Embodiment Construction

[0019] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments. But the following embodiments are only limited to explain the present invention, and the protection scope of the present invention should include the entire content of the claims, not only limited to the present embodiment.

[0020] The invention relates to a rapid detection method for volatile N-nitrosamines in cosmetics. The steps are: weighing a small amount of cosmetic samples, adding amine sulfamate and acetone for ultrasonic dissolution, and extracting with dichloromethane layer after refrigerated centrifugation. The quantitative detection of target compounds was realized by gas chromatography-thermal energy analyzer. details as follows:

[0021] 1. Reagents and Materials

[0022] Unless otherwise stated, all reagents used were of analytical grade.

[0023] 1.1N-Nitrosodiethylamine: the purity is greater than 98%;

[0024] 1.2 N-nitro...

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Abstract

The invention relates to a method for quickly detecting volatile N-nitrosamine in cosmetics. The method comprises the following steps: weighing a small amount of cosmetics; adding ammonium sulfamate and acetone, performing ultrasonic dissolution and refrigerated centrifugation, and extracting with a dichloromethane layer; and performing a gas phase chromatography-thermal energy analyzer method on the extract solution to realize quantitative detection of a target compound. According to the invention, the method can effectively detect out volatile N-nitrosamine in water-soluble or fat-soluble cosmetics, has the advantages of simple pretreatment, little time consumption, low cost and high accuracy, is applicable to actual detection of cosmetics, and can provide a technical method support for detection of volatile N-nitrosamine in cosmetics and production quality control.

Description

technical field [0001] The invention relates to the technical field of chemical instrument detection, in particular to a rapid sample processing and detection method for volatile N-nitrosamines in cosmetics and raw materials. Background technique [0002] N-nitrosamines (NAms) are a kind of nitroso compounds and one of the three major carcinogens recognized in the world. Cosmetics, as daily necessities, will stay on the skin, hair, nails, lips and other parts for a long time, and their safety has attracted much attention. There are a certain amount of precursors of N-nitrosamines such as secondary amines and alkylamines in the raw materials of cosmetics. Therefore, these precursors are very easy to generate N-nitrosamines through nitro reaction during the production, storage and sales of cosmetics. According to the classification of the International Agency for Research on Cancer (IARC), 5 volatile N-nitrosamines commonly found in cosmetics: N-nitrosodiethylamine, N-nitroso...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/02
CPCG01N30/06G01N30/02
Inventor 计敏刘华刘勇王贻坤朱灵孙淼张龙吴晓松李志刚
Owner ANHUI YIKANGDA PHOTOELECTRIC TECH CO LTD
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