A pharmaceutical composition for treating non-alcoholic fatty liver and its preparation method and application

A composition and fatty liver technology, applied in the directions of drug combination, pharmaceutical formula, application, etc., can solve the problem that the curative effect needs to be further improved, and achieve the effects of improving liver histology, precise formula, and reducing the degree of deposition.

Active Publication Date: 2019-12-06
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Zhang Chuantao et al., "The Effects of Modified Zhaqu Decoction on the FFA-CYP2E1-MDA Pathway in Rats with Experimental Non-alcoholic Fatty Liver", Shizhen National Medicine, Vol. For fatty liver disease, the medicine composition of Jiawei Zhaqu Decoction consists of more than ten kinds of jaggery 30g, raw hawthorn 30g, divine music 20g, lotus leaf 20g, Alisma 10g, salvia miltiorrhiza 15g, turmeric 12g, gynostemma 15g, bupleurum 9g, medlar 15g, etc. flavored traditional Chinese medicine, but its curative effect needs to be further improved

Method used

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  • A pharmaceutical composition for treating non-alcoholic fatty liver and its preparation method and application
  • A pharmaceutical composition for treating non-alcoholic fatty liver and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation of the pharmaceutical composition of the present invention

[0019] Take raw hawthorn 30g, burnt hawthorn 30g, Shenqu 20g, Baizhu 15g, lotus leaf 20g, Alisma orientalis 10g, turmeric 15g, cassia seed 10g, and coptis 6g.

[0020] The first step: Put the medicinal materials in the casserole, add 2000ml of water, and soak for half an hour. The second step: After boiling with martial fire (high fire), then boil with low fire (low fire) until the remaining 300ml is left, and pour the boiled liquid medicine into a bowl. The third step: Repeat the first and second steps, and take it twice.

Embodiment 2

[0021] Example 2 Preparation of the pharmaceutical composition of the present invention

[0022] Take raw hawthorn 20g, burnt hawthorn 20g, Jianqu 10g, Atractylodes macrocephala 10g, lotus leaf 10g, Alisma orientalis 5g, turmeric 10g, cassia seed 5g, and Coptis 3g.

[0023] Step 1: Put the medicinal materials in a casserole, add 2000ml of water, and soak for half an hour. The second step: After boiling with martial fire (high fire), then boil with low fire (low fire) until the remaining 300ml is left, and pour the boiled liquid medicine into a bowl. The third step: Repeat the first and second steps, and take it twice.

Embodiment 3

[0024] Example 3 Preparation of the pharmaceutical composition of the present invention

[0025] The raw hawthorn 40g, the coke hawthorn 40g, Jianqu 30g, Baizhu 20g, lotus leaf 30g, Alisma 15g turmeric 20g, cassia seed 15g, and Coptis 9g.

[0026] The first step: Put the medicinal materials in the casserole, add 2000ml of water, and soak for half an hour. The second step: After boiling with martial fire (high fire), then boil with low fire (low fire) until the remaining 300ml is left, and pour the boiled liquid medicine into a bowl. The third step: Repeat the first and second steps, and take it twice.

[0027] Hereinafter, the beneficial effects of the present invention will be specifically described through test examples.

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Abstract

The invention discloses a food, health product and medicinal composition for treating the non-alcoholic fatty liver disease, which is a preparation prepared from the following raw material medicines by weight: 20 to 40 parts of raw fructus crataegi, 20 to 40 parts of scorched fructus crataegi, 10 to 30 parts of medicated leaven, 10 to 20 parts of rhizoma atractylodis macrocephalae, 10 to 30 parts of folium nelumbinis, 5 to 15 parts of rhizoma alismatis, 10 to 20 parts of rhizoma curcumae longae, 5 to 15 parts of cassiae semen, and 3 to 9 parts of rhizoma coptidis. The invention further discloses a preparation method and application of the composition. The medicinal composition disclosed by the invention can effectively treat the non-alcoholic fatty liver disease, and has a wide application prospect.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating non-alcoholic fatty liver and its preparation method and application. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function enzymes and chronic liver disease in Western developed countries such as Europe and the United States, including non-alcoholic simple fatty liver (NAFL). ), non-alcoholicsteatohepatitis (NASH) and related liver cirrhosis and hepatocellular carcinoma. The prevalence of NAFLD in ordinary adults is 20% to 33%, of which NASH and liver cirrhosis account for 10% to 20% and 2% to 3%, respectively. The prevalence of NAFL in obese patients is 60% to 90% (where NASH is 20% to 25%, and liver cirrhosis is 2% to 8%). The prevalence of NAFLD in patients with type 2 diabetes and hyperlipidemia is 28%, respectively ~55% and 27%~92%, in the body mass index> 30kg / m 2 Up to 80% of the population. In recent years, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P1/16A23L33/105
CPCA23V2002/00A61K36/00A61K36/284A61K36/482A61K36/62A61K36/718A61K36/734A61K36/884A61K36/9066A61K2236/19A61K2300/00A23V2200/32A23V2250/21
Inventor 张传涛廖婷婷黄群马喜桃杨鸿辜海英郭尹玲张技
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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