Microfluidic chip that generates oil-water-oil and water-oil-water droplets

Abstract

The invention relates to a microfluidic chip capable of generating two types of droplets, oil-water-oil and water-oil-water, comprising a first hydrophobic layer, a second hydrophobic layer, a first hydrophilic layer, and a second hydrophilic layer ; The surface of the first hydrophobic layer is provided with a first through hole, a second through hole, a third through hole, and a fourth through hole; the surface of the second hydrophobic layer is provided with a fifth through hole, a sixth through hole, and a fourth through hole. Seven through holes and eighth through holes; the first microchannel unit is opened on the left part of the upper surface of the second hydrophobic layer, and the second microchannel unit is opened on the right part; the ninth through hole is opened on the surface of the first hydrophilic layer , the tenth through hole, the eleventh through hole, and the twelfth through hole; a cross-shaped channel is opened on the lower surface of the first hydrophilic layer. The present invention solves the problem that there is no microfluidic chip that integrates two or more materials and can prepare both oil-water-oil droplets and water-oil-water droplets. The invention is applicable to the fields of biological detection, drug screening, cell research, material synthesis and the like.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to a microfluidic chip capable of generating oil-water-oil and water-oil-water droplets. Background technique [0002] The microfluidic chip integrates or basically integrates the basic operation units such as sample preparation, separation, mixing, reaction and detection involved in the fields of biology and chemistry into a chip of a few square centimeters (or even smaller), relying on the chip. Functional devices such as micro-pipes, micro-valves, liquid reservoirs, micro-electrodes, micro-detection elements, and connectors control fluid throughout the entire system, and are used to replace a technical platform for various functions of conventional biological or chemical laboratories, so it is also called For the lab-on-a-chip (lab-on-a-chip). The microfluidic chip can integrate the sampling, dilution, concentration, mixing, separation, reaction and detection of routine experiments into fu...

AI Technical Summary

Problems solved by technology

[0005] At present, chips for preparing water-oil-water and oil-water-oil droplets generally use one material, and the surface hydrophilic and hydrophobic properties of a single material are fixed, which requires modification of the surface, resulting in The following problems: First, the process of surface modification is cumbersome, and it is necessary to protect the parts that do not need to be modified during the modification process

However, there is currently no such droplet microfluidic chip

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