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Preparation method of gadolinium-modified bismuth sulfide nanometer diagnosing agent

A bismuth sulfide and nanotechnology, which is used in the preparation of X-ray contrast agents, preparations for in vivo experiments, and medical preparations containing active ingredients, etc., can solve the problem that the imaging speed is not fast enough, the dynamic images of tissues and organs cannot be observed, absorption problems such as low coefficients, to achieve the effect that is conducive to diagnosis

Inactive Publication Date: 2017-02-15
HUBEI UNIV OF TECH
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Problems solved by technology

However, these materials have their own shortcomings: the absorption coefficient of carbon-based nanomaterials in the near-infrared region is very low, and the photothermal conversion efficiency is not ideal; organic compound nanomaterials have serious photobleaching, and the photothermal conversion efficiency is not satisfactory. ; Metal nanomaterials have received extensive attention and research due to their variety and shape.
However, the disadvantage of MRI imaging is that the imaging speed is not fast enough to observe and collect dynamic images of tissues and organs, and it is impossible to perform MRI imaging on patients with cardiac pacemakers or other metal objects in the body an examination

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  • Preparation method of gadolinium-modified bismuth sulfide nanometer diagnosing agent

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[0042] The present invention will be further described in detail through specific embodiments below. However, those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. In addition, those that do not indicate the specific technical operation steps or conditions in the examples are all carried out according to the conventional techniques or conditions described in the literature in this field or according to the product instructions. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0043] (1) Preparation of bismuth sulfide nanomaterials:

[0044] ① Measure oleic acid (13.33mL) and octadecene (26.67mL) in a flask, and add bismuth neodecanoate (2.096mL) into the flask under vigorous stirring;

[0045] ② in N 2 Under protection, the mixture was heated to...

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Abstract

The invention discloses a preparation method of a gadolinium-modified bismuth sulfide nanometer diagnosing agent used for MRI (magnetic resonance imaging) and CT (computerized tomography) double-mode imaging instruction. According to the preparation method, oleic acid, oleylamine, 1-octadecene, neodecanoic acid bismuth and thioacetamide are used as raw materials to composite bismuth sulfide, diethylenetriamine pentaacetic acid bicycle-anhydride and bismuth trichloride are used to prepare a Dd-DTPA-OA ligand, and then the Dd-DTPA-OA ligand is modified by the bismuth sulfide to obtain a gadolinium-modified bismuth sulfide nanometer material. The preparation method of the gadolinium-modified bismuth sulfide nanometer diagnosing agent has the advantages that a research background of an existing medical contrast agent is combined, a CT / MRI double-mode contrast agent preparation is simplified, and the preparation method is simple in preparation, highly controllable, high in efficiency, easy for industrialized production and the like.

Description

technical field [0001] The invention relates to the field of preparation and application of nano-composite materials with imaging function, in particular to a preparation method of a novel gadolinium-modified bismuth sulfide nano-diagnosis and treatment agent guided by dual-mode imaging of MRI and CT. Background technique [0002] Currently, there are three traditional methods of treatment for tumors: surgery, radiotherapy, and chemotherapy. However, surgical treatment cannot completely cure those advanced patients with metastatic tumors, and the secondary damage caused by chemotherapy and radiotherapy is more than that caused by the cancer itself. Although the traditional treatment methods of the three major cancers have their own advantages and complement each other, thus playing a pivotal role in the treatment of tumors, these three traditional treatment methods all have certain deficiencies. Therefore, exploring the latest tumor treatment method with less toxic and side...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/10A61K49/04A61K41/00A61P35/00
CPCA61K49/105A61K41/0052A61K49/04
Inventor 孙红梅郭洪影
Owner HUBEI UNIV OF TECH
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