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Hebephrenic type schizophrenia associated gene

A schizophrenia and youth-type technology, which is applied in genetic engineering, plant gene improvement, and neurotransmitter receptors, can solve the problems of undiscovered susceptibility genes for youth-type schizophrenia, achieve good therapeutic effect and simple operation , Symptomatic effect

Inactive Publication Date: 2017-02-22
张建华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Recent genome-wide scanning results suggest that chromosome 11 is associated with susceptibility to adolescent-onset schizophrenia, but so far no specific susceptibility genes associated with adolescent-onset schizophrenia have been found in this chromosome region

Method used

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  • Hebephrenic type schizophrenia associated gene
  • Hebephrenic type schizophrenia associated gene
  • Hebephrenic type schizophrenia associated gene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Select candidate genes and SNPs

[0046] The present inventor consults literature, utilizes computer Internet and bioinformatics to obtain various aspects of schizophrenia candidate gene research, and carries out single nucleotide polymorphism (SNP) linkage disequilibrium analysis by linkage disequilibrium analysis method on No. 11 chromosome, through NCBI

[0047] (http: / / www.ncbi.nlm.nih.gov / mapviewer) database, access to DRD2 gene, and via http: / / www.ncbi.nlm.nih.gov / SNP, http: / / snp.cshl.org / database to search for candidate gene SNPs that meet its conditions. The selection criteria: 1. There have been relevant literature reports;

[0048] 2. The minimum allele frequency of the site should be greater than 10%; 3. The selected SNPs must meet the requirements of the primer design software; 4. The selected site cannot affect the genotyping experiment

[0049] 2. Materials and methods

[0050] 2.1 Research object

[0051] The present invention takes 320 cases of ...

Embodiment 2

[0093] 1. Research object

[0094] The present invention takes 50 confirmed cases of adolescent schizophrenia and 50 cases of healthy controls (in good health, without physical disease, without family hereditary disease history, without mental disease history, without drug abuse) as research objects. All subjects were Chinese Han people, and they voluntarily signed the informed consent form approved by the ethics committee.

[0095] 2. Collection of blood and clinical data

[0096] After the subjects carefully read, understood, and voluntarily signed the informed consent form approved by the ethics committee, 5ml of peripheral venous blood was collected and stored at -20°C until genomic DNA was extracted. Collect age, gender, family history, ethnicity and education level, time of first admission and diagnosis, clinical symptoms, cognitive function and other disease-related data of patients with schizophrenia; collect general demographic data and cognitive function rating scal...

Embodiment 3

[0116] 1. Research object

[0117] The present invention takes 40 confirmed cases of adolescent schizophrenia and 40 cases of healthy controls (healthy, no physical disease, no family hereditary disease history, no mental disease history, no drug abuse) as research objects. All subjects were Chinese Han people, and they voluntarily signed the informed consent form approved by the ethics committee.

[0118] 2. Collection of blood and clinical data

[0119] After the subjects carefully read, understood, and voluntarily signed the informed consent form approved by the ethics committee, 5ml of peripheral venous blood was collected and stored at -20°C until genomic DNA was extracted. Collect age, gender, family history, ethnicity and education level, time of first admission and diagnosis, clinical symptoms, cognitive function and other disease-related data of patients with schizophrenia; collect general demographic data and cognitive function rating scale for normal people .

[...

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Abstract

The invention provides an associated gene closely associated with hebephrenic type schizophrenia, namely a DRD2 gene located at 11q23; because a mononucleotide polymorphism rs1800497 base C of the gene is mutated to T, the gene is associated with susceptibility of the hebephrenic type schizophrenia, individuals with the rs1800497 base of T are a hebephrenic type schizophrenia susceptible group, and individuals with the rs1800497 base of C are a group less susceptible to the hebephrenic type schizophrenia; the DRD2 gene and an encoded protein thereof have important guiding significance on elucidating a hebephrenic type schizophrenia genetic mechanism, establishing a gene diagnosis method, and guiding hebephrenic type schizophrenia diagnosis and prevention and development of novel treatment drugs.

Description

technical field [0001] The invention relates to a susceptibility gene significantly associated with schizophrenia, in particular to a susceptibility gene significantly associated with juvenile schizophrenia. Background technique [0002] Schizophrenia is a chronic, severe, and disabling encephalopathy that seriously endangers human health. Schizophrenia is the most serious mental illness among mental illnesses. According to the Lancet survey in 2009, the number of schizophrenia patients in my country is nearly 10 million. Schizophrenia requires lifelong treatment, and the cost of treatment is high. According to statistics, the total cost of schizophrenia treatment in the United States in 2002 reached 62.7 billion US dollars, of which 22.7 billion US dollars were direct costs, premature deaths due to suicide and losses caused by family members taking care of patients etc. is 32.4 billion US dollars, and schizophrenia is highly disabling. Most patients with schizophrenia will...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C12Q1/68
CPCC07K14/70571C12Q1/6883C12Q2600/156C12Q2600/172
Inventor 不公告发明人
Owner 张建华
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