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Detecting method of fuyankang tablet
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A detection method and technology for Fuyankang tablets, applied in the field of detection of Fuyankang tablets, can solve problems such as product effectiveness and safety cannot be better reflected, no detection of blood-activating and stasis-removing drugs, and inability to ensure product clinical efficacy. , to achieve the effect of increasing content determination and stable properties
Active Publication Date: 2017-02-22
吉林省中研药业有限公司
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[0012] The invention provides a detection method of Fuyankang Tablets to solve the existing detection method that does not detect the active ingredients of blood-activating and stasis-removing drugs, and takes into account the detection of other active ingredients, so that the effectiveness and safety of the product cannot be tested. Better reflection, so that the clinical efficacy of the product cannot be ensured
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[0038] Including the following identification methods and content determination methods:
[0039]Identification (1), take 6 small or 3 large tablets of this product, remove the sugar coating from the sugar-coated tablets, grind finely, add 30ml of methanol, ultrasonicate for 30 minutes, filter, evaporate the filtrate to dryness, add 20ml of water to the residue to dissolve, extract twice with ether, 20ml each time, combined ether solution, and set aside; the aqueous solution was extracted twice with water-saturated n-butanol, 20ml each time, combined n-butanol solution, steamed to nearly 2ml, added 100-200 mesh neutral alumina 2g, mixed on a water bath Uniform, dry, add on neutral alumina column, 100-200 mesh, 2g, inner diameter 0.9cm, successively with ethyl acetate:methanol=2:1, ethyl acetate:methanol=1:1 and 80% methanol respectively 10ml elution, collect 80% methanol eluate, evaporate to dryness, add methanol 1ml to the residue to dissolve, and use it as the test solution;...
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Abstract
The invention relates to a detecting method of a fuyankang tablet, and belongs to the field of Chinese pharmaceutical manufacturing detecting. The detecting method comprises the steps of conducting thin-layer chromatographic identification of root of common peony and curcuma zedoary and measuring the content of tanshinol in a finished product through high performance liquid chromatography. The detecting method of a fuyankang tablet has the advantages of starting from a drug which has a major function of invigorating blood circulation and eliminating stasis, aiming at properties of materials containing effective constituents, taking the factor that effective constituent paeoniflorin is unstable in Chinese herbaceous peony into consideration so as to increase an identification item; taking the factor that the property of effective constituent tanshinol in the root of red-rooted salvia is stable into consideration so as to increase a content determination; adding into the identification items an identification item of curcuma zedoary which is a drug of promoting qi circulation to relieve pain, in this way, one content determination and two identifications are added to a 13-odor traditional Chinese medicine formula, and through the combination of the added one content determination and two identifications with the original one content determination and three identifications, the quality of the product is controlled effectively; being capable of meeting the requirement of producing high quality products so as to ensure that the products have the best therapeutic effects.
Description
technical field [0001] The invention belongs to the field of detection of traditional Chinese medicines, and in particular relates to a detection method of Fuyankang Tablets. Background technique [0002] Fuyankang tablets are made of 60g of red peony root, 100g of soil tuckahoe, 60g of vinegar three-lens, 60g of fried toosendan, 60g of vinegar curcuma, 60g of vinegar corydalis, 100g of fried gorgon, 100g of angelica, 60g of flavescens, 40g of vinegar cyperus, Phellodendron cortex 60g, Danshen 100g, Chinese yam 120g. [0003] The above thirteen flavors, vinegar curcuma and yam are crushed into fine powder, sieved, and the other eleven flavors, such as vinegar triangular, are decocted in water for three times, the first time is 2 hours, the second and third times are 1 hour each, and the decoction is filtered. Combine the filtrates, concentrate to an appropriate amount, mix with the above powder, dry, crush into fine powder, add appropriate amount of sucrose, starch and magn...
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