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An Improved Detection Method for Yulan Jiangtang Capsules

A detection method, Yulan hypoglycemic technology, applied in the direction of capsule delivery, measuring devices, pharmaceutical formulations, etc., can solve problems such as uneven moisture, spot tailing, and easy destruction of active ingredients, so as to improve the antibacterial ability of products, Effect of improving the quality situation and shortening the drying time

Active Publication Date: 2022-04-01
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Technical problems in this preparation method: (1) Because baicalin will be enzymatically hydrolyzed into baicalein and glucuronic acid under the action of baicalinase, baicalein is insoluble in water and unstable, and it is easy to precipitate on the surface of baicalin and be oxidized in the air into green quinone derivatives. This method adopts cold water to directly decoct, and the surface of Scutellaria baicalensis is easily oxidized into green quinone derivatives in the air, which affects the transfer rate of baicalin and the antibacterial ability of products; Concentration under high pressure, high concentration temperature, easy to destroy active ingredients; (3) hot air circulation oven drying method, long drying time, uneven moisture, affecting drug quality and other problems
[0005] The quality of Yulan Jiangtang Capsules prepared after the improved preparation method was tested according to the State Drug Administration standard (WS-10113(ZD-0113)-2002), and some of the test results had the following problems: (1) Identification experiment of Scutellaria baicalensis Among them, the spots were blurred, and the Rf value of the spot after the sample was too small, which affected the judgment of the test results; (2) In the identification experiment of arctium medicinal materials, the spots trailed off, the separation degree was small, and the reproducibility was poor, which affected the judgment of the test results; (3) ) The quality lacks the identification detection of Scutellaria barbata; (4) The quality lacks the detection of rutin content in mulberry leaves

Method used

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Examples

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Embodiment 1

[0050] Recipe: 620g of skullcap, 285g of mulberry leaves, 260g of burdock, 180g of blue ginseng, 170g of Scutellaria barbata, 120g of false longevity bamboo root, 93g of green fennel.

[0051] Preparation method: (1) Take 30g of mulberry leaves and grind them into fine powder; (2) Put the remaining mulberry leaves and other six flavors such as Scutellaria baicalensis into the extraction tank, close the feeding port after feeding, open the exhaust valve, and add to the storage tank first. Water with 6 times the amount of medicinal materials is boiled with a concentrator, pumped into the extraction tank, and steam is turned on to heat and decoct twice, the first time is 2 hours, and the second time is 1.5 hours; -0.06Mpa, the concentration temperature is 65°C, and the vacuum concentration is reduced to a clear paste with a relative density of 1.18; 3) Add mulberry leaf fine powder, mix well, and dry at a drying temperature of 120°C, a vacuum degree of -0.085Mpa, and a crawler spe...

Embodiment 2

[0053] Prescription: with embodiment 1.

[0054] Preparation method: (1) Take 30g of mulberry leaves and grind them into fine powder; (2) Put the remaining mulberry leaves and other six flavors such as Scutellaria baicalensis into the extraction tank, close the feeding port after feeding, open the exhaust valve, and add to the storage tank first. Water with 6 times the amount of medicinal materials is boiled with a concentrator, pumped into the extraction tank, and steam is turned on to heat and decoct twice, the first time is 2 hours, and the second time is 1.5 hours; -0.04MpaMpa, the concentration temperature is 50°C, vacuum decompression and concentration to a clear paste with a relative density of 1.17; 3) add mulberry leaf fine powder, mix well, and dry at a temperature of 80°C, vacuum degree -0.085Mpa, crawler speed 120mm / min, feed pump 100rpm, crushing frequency 40Hz, dry for 4 hours, crush into fine powder, sieve, mix, pack into capsules, and get ready.

Embodiment 3

[0056] Prescription: with embodiment 1.

[0057] Preparation method: (1) Take 30g of mulberry leaves and grind them into fine powder; (2) Put the remaining mulberry leaves and other six flavors such as Scutellaria baicalensis into the extraction tank, close the feeding port after feeding, open the exhaust valve, and add to the storage tank first. Water with 6 times the amount of medicinal materials is boiled with a concentrator, pumped into the extraction tank, and steam is turned on to heat and decoct twice, the first time is 2 hours, and the second time is 1.5 hours; -0.09Mpa, the concentration temperature is 80°C, and the vacuum concentration is reduced to a clear paste with a relative density of 1.20; 3) Add mulberry leaf fine powder, mix well, and dry at a temperature of 150°C, vacuum degree -0.085Mpa, crawler speed 180mm / min, feed pump 130rpm, crushing frequency 60Hz, dry for 8 hours, crush into fine powder, sieve, mix, pack into capsules, and get ready.

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Abstract

The invention relates to an improved preparation method and detection method of Yulan Jiangtang Capsules. In the preparation method, the feeding temperature control parameters of Scutellaria baicalensis are adjusted in the extraction stage, and the cold water feeding of Scutellaria baicalensis medicinal material is changed to boiling water feeding, which destroys the activity of baicalinase and eliminates Enzymolysis of Scutellaria baicalensis was used to improve the transfer rate of baicalin and the antibacterial ability of the product; vacuum concentration was used in the concentration stage to reduce the concentration temperature, so that the active ingredients were not damaged; a low-temperature vacuum belt drying method was used in the drying stage to shorten the production time. Drying time, improve production efficiency and save production cost. The detection method includes the optimization of TLC identification of Scutellaria baicalensis and Radix Arctium in capsules, the optimization of the determination method of baicalin in capsules, and the addition of TLC identification items of Scutellaria barbata. Through methodological investigation, the detection method is specific Strong, durable, good recovery and other effects, can effectively detect and improve the quality of the preparation process products, and further improve product quality.

Description

technical field [0001] The invention relates to the field of medicine preparation and detection, in particular to an improved preparation method and detection method of Yulan Jiangtang Capsules. Background technique [0002] Yulan Jiangtang Capsule is a product of Guizhou Jianxing Pharmaceutical Co., Ltd. It has the functions of clearing heat and nourishing yin, promoting body fluid and quenching thirst. It is used for the improvement of diabetes caused by yin deficiency and internal heat, type 2 diabetes and complications; it consists of 620g of Scutellaria baicalensis, 285g of mulberry leaves, 260g of burdock seeds, 180g of blue ginseng, 170g of Scutellaria barbata, 120g of false longevity bamboo root, green It consists of 93g of fennel, and the preparation method is as follows; 1) take 30g of mulberry leaves and grind them into fine powder; 2) put the remaining mulberry leaves and the rest of Scutellaria baicalensis into the extraction tank, close the feeding port after f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/02G01N30/06A61K36/896A61K9/48A61P3/10
CPCA61K36/539A61K36/605A61K36/28A61K36/896A61K36/21A61K36/30A61K36/34A61K9/48A61P3/10G01N30/02G01N30/06G01N30/90A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 孙小鹦廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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