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Improved preparation method and detection method of Yulan hypoglycemic capsules

A detection method, Yulan hypoglycemic technology, applied in the directions of capsule delivery, medical preparations containing active ingredients, measuring devices, etc. Bacterial capacity, improve product quality and improve production efficiency

Active Publication Date: 2021-10-26
贵州健兴药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Technical problems in this preparation method: (1) Because baicalin will be enzymatically hydrolyzed into baicalein and glucuronic acid under the action of baicalinase, baicalein is insoluble in water and unstable, and it is easy to precipitate on the surface of baicalin and be oxidized in the air into green quinone derivatives. This method adopts cold water to directly decoct, and the surface of Scutellaria baicalensis is easily oxidized into green quinone derivatives in the air, which affects the transfer rate of baicalin and the antibacterial ability of products; Concentration under high pressure, high concentration temperature, easy to destroy active ingredients; (3) hot air circulation oven drying method, long drying time, uneven moisture, affecting drug quality and other problems
[0005] The quality of Yulan Jiangtang Capsules prepared after the improved preparation method was tested according to the State Drug Administration standard (WS-10113(ZD-0113)-2002), and some of the test results had the following problems: (1) Identification experiment of Scutellaria baicalensis Among them, the spots were blurred, and the Rf value of the spot after the sample was too small, which affected the judgment of the test results; (2) In the identification experiment of arctium medicinal materials, the spots trailed off, the separation degree was small, and the reproducibility was poor, which affected the judgment of the test results; (3) ) The quality lacks the identification detection of Scutellaria barbata; (4) The quality lacks the detection of rutin content in mulberry leaves

Method used

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  • Improved preparation method and detection method of Yulan hypoglycemic capsules
  • Improved preparation method and detection method of Yulan hypoglycemic capsules
  • Improved preparation method and detection method of Yulan hypoglycemic capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Formulation: Astragalus 620g, mulberry leaves 285g, burdock 260g, blue flower ginseng 180g, half lotus 170g, fake Wanshou bamboo root 120g, blue scorpion 93g.

[0051] Preparation method: (1) Take the mulberry leaves 30g into fine powder; (2) Put the remaining mulberry leaves and the remaining shafts, etc. With 6 times the water, after boiling with a concentrator, use the pump to enter the extract, open the steam heating and decorate it twice, the first time 2 hours, the second 1.5 hours; (3) combined with fried liquid, with vacuum In -0.06MPa, the concentration temperature was 65 ° C for vacuum reduced pressure concentrated to the relatively dense cleaner; 3) Add mulberry leaves, mix, mixed, vacuum -0.085MPa, crawler speed 150mm / min, the feed pump 120 rpm, the pulverization frequency is 50 Hz for 5 hours, pulverized into fine powder, sieve, mix, load the capsule,

Embodiment 2

[0053] Formulation: In Example 1.

[0054] Preparation method: (1) Take the mulberry leaves 30g into fine powder; (2) Put the remaining mulberry leaves and the remaining shafts, etc. With 6 times the water, after boiling with a concentrator, use the pump to enter the extract, open the steam heating and decorate it twice, the first time 2 hours, the second 1.5 hours; (3) combined with fried liquid, with vacuum For -0.04 MPAMPA, the concentration temperature was 50 ° C for vacuum reduced pressure concentrated to a relatively dense cleaner; 3) Add mulberry leaves, mix, mixed temperature 80 ° C, vacuum -0.085MPa, crawler speed 120mm / min, the feed pump 100 rpm, the pulverization frequency is 40 Hz for 4 hours, pulverized into fine powder, sieve, mix, load the capsule,

Embodiment 3

[0056] Formulation: In Example 1.

[0057] Preparation method: (1) Take the mulberry leaves 30g into fine powder; (2) Put the remaining mulberry leaves and the remaining shafts, etc. With 6 times the water, after boiling with a concentrator, use the pump to enter the extract, open the steam heating and decorate it twice, the first time 2 hours, the second 1.5 hours; (3) combined with fried liquid, with vacuum To -0.09MPa, the concentration temperature was 80 ° C for vacuum reduced pressure to a cleaner concentrated to a relatively density of 1.20; 3) Add mulberry leaves, mix, mixed temperature 150 ° C, vacuum -0.085MPa, crawler speed 180mm / min, feed pump 130 rpm, pulverized frequency 60Hz for drying 8 hours, pulverized into fine powder, sieving, mixing, loading capsules,

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PUM

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Abstract

The invention relates to an improved preparation method and detection method of Yulan hypoglycemic capsules. According to the preparation method, temperature control parameters of baical skullcap root feeding are adjusted in the extraction stage, baical skullcap root medicinal material cold water feeding is changed into boiling water feeding, the activity of baical skullcap root enzyme is destroyed, baical skullcap root enzymolysis is eliminated, and the baicalin transfer rate and the product bacteriostatic ability are improved; vacuum concentration is adopted in the concentration stage, so that the concentration temperature is reduced, and effective components are not damaged; and a low-temperature vacuum belt type drying method is adopted in the drying stage, so that the drying time is shortened, the production efficiency is improved, and the production cost is saved. The detection method comprises optimization of thin-layer identification of baical skullcap root and fructus arctii medicinal materials in capsules and optimization of a method for determining the content of baicalin in the capsules, and a thin-layer identification item of sculellaria barbata medicinal material is added; and methodological investigation shows that the detection method has the effects of high specificity, good durability, good recovery rate and the like, the quality condition of an improved preparation process product can be effectively detected, and the product quality is further improved.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical preparation and detection, and more particularly to an improved method and detection method of jade blueprint capsule capsule. Background technique [0002] The jade blue sugar capsule is the product of Guizhou Jianxing Pharmaceutical Co., Ltd., and the effect is clear and hot, and it is thirsty. Improvement of thirst, type 2 diabetes and complications caused by yin deficiency; 620g, mulberry leaves, 285g, burdock 260g, blue flower ginseng 180g, half lotus 170g, fake lotus bamboo root 120g, blue The scorpion 93g is composed, the preparation method is; 1) Take the mulberry leaves 30g into thin powder; 2) The remaining mulberry leaves are put into the tank with the remaining shafts, and the pounding port is closed after the fence, open the drinking water valve plus 6 times Water, open the clamp steam for decancing twice, for the first 2 hours, second 1.5 hours; 3) Combined with decoction, concentrat...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/48A61P3/10G01N30/02G01N30/06G01N30/90
CPCA61K36/539A61K36/605A61K36/28A61K36/896A61K36/21A61K36/30A61K36/34A61K9/48A61P3/10G01N30/02G01N30/06G01N30/90A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 孙小鹦廖萍廖伟廖忠
Owner 贵州健兴药业有限公司
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