Preparation method of calcium lactate tablet

A calcium lactate and prescription technology, which is applied in the direction of non-active ingredients medical preparations, pharmaceutical formulas, anhydride/acid/halide active ingredients, etc., can solve the problems of cumbersome process technology, incapable of large-scale production, and high preparation cost, and achieve The effect of uniform content, short disintegration time limit and simple operation

Inactive Publication Date: 2017-03-29
青岛华迈士药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problems of cumbersome process technology, high preparation cost, and incapability of large-scale production, the present invention adopts the following technical solutions to achieve:

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Ingredients: The raw and auxiliary materials required for ingredients are calcium lactate, dextrin, starch, the anti-sticking agent is magnesium stearate, and the adhesive is 95% ethanol for medicine;

[0021] (2), the preparation of adhesive: take by weighing 95% ethanol of recipe quantity, add appropriate amount of purified water, be adjusted to 40% with alcohol meter and stand-by;

[0022] (3) Pretreatment of raw and auxiliary materials: calcium lactate, dextrin, and starch are respectively passed through an 80-mesh sieve, and put into a clean and dry plastic bag for subsequent use;

[0023] (4) Mixing and granulation: Weigh calcium lactate, dextrin, and starch according to the prescription and place them in a high-speed mixing granulator, start stirring and mixing for 6 minutes, mix well, add 40% ethanol solution while stirring, cut and stir to make Granulate for 8 minutes to make suitable granules;

[0024] (5) Drying: spread the wet granules evenly on a clean...

Embodiment 2

[0028] (1) Ingredients: The raw and auxiliary materials required for ingredients are calcium lactate, dextrin, starch, the anti-sticking agent is magnesium stearate, and the adhesive is 95% ethanol for medicine;

[0029] (2), the preparation of adhesive: take by weighing 95% ethanol of recipe quantity, add appropriate amount of purified water, be adjusted to 40% with alcohol meter and stand-by;

[0030] (3) Pretreatment of raw and auxiliary materials: calcium lactate, dextrin, and starch are respectively passed through an 80-mesh sieve, and put into a clean and dry plastic bag for subsequent use;

[0031] (4) Mixing and granulation: Weigh calcium lactate, dextrin, and starch according to the prescription and place them in a high-speed mixing granulator, start stirring and mixing for 5 minutes, mix well, add 40% ethanol solution while stirring, cut and stir to make Granulate for 8 minutes to make suitable granules;

[0032] (5) Drying: Spread the wet granules evenly on clean a...

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PUM

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Abstract

The invention discloses a preparation method of a calcium lactate tablet. The provided calcium lactate tablet is used to prevent and treat calcium deficiency, such as osteoporosis, tetany, dysosteogenesis, rickets, and the like, and can supply calcium to children, pregnant women, lactating women, and elders. The calcium lactate tablet has a long acting effect, the disintegration time is shortened, and the adverse reactions are reduced. The raw materials and auxiliary materials are easily available, the preparation process is relatively simple, the procedure is not complicated, the cost is low, and the preparation method is suitable for massive production.

Description

technical field [0001] The invention relates to the field of chemical and pharmaceutical technology, in particular to a method for effectively preparing calcium lactate tablets. Background technique [0002] Calcium lactate, molecular formula: (CH3CHOHCOO)2Ca·5H2O, is a-hydroxypropionate calcium pentahydrate. Calcium lactate has high solubility, fast dissolution rate, high bioavailability and good taste, and is widely used in dairy products, beverages, food health products and other fields. It is also mostly used as a food additive, a fortifier of children's nutritional food, and medically used to supplement calcium. [0003] Calcium lactate is a good food calcium fortifier, and its absorption effect is better than inorganic calcium. It can be used in food for infants and young children, and the dosage is 23-46g / kg; in cereals and their products, it is 12-24g / kg; in drinking liquid and milk beverage, it is 3-6g / kg. It is also used as a leavening agent and buffer for bread...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/19A61K47/36A61P3/02
CPCA61K9/2059A61K31/19
Inventor 刘乃山郭利陈娥功
Owner 青岛华迈士药业有限公司
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