Lung cancer marker and applications thereof

A marker and tumor marker technology, applied in the field of medical molecular biology, can solve the problems of lack of specificity and limited diagnostic value of lung cancer
CN106568955AInactive Publication Date: 2017-04-19ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2017-04-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a lung cancer marker, which is a TREM-2 protein. The marker is a membrane surface acceptor, which is specifically expressed to myeloid derived dendritic cells and mononuclear macrophage, and belongs to the immunoglobulin superfamily. The expression of TREM-2 in peripheral blood mononuclear cells of lung cancer patients and tumor-bearing mice is obviously higher than the expression of TREM-2 in peripheral blood mononuclear cells of healthy persons and normal mice. The immunohistochemical method detection shows that high expression of TREM-2 exists in the macrophage of lung cancer patients and TREM-2 is in positive correlation with the development of lung cancer. The novel tumor marker (triggering receptors expressed on myeloid cells) namely TERM-2 can be used as a molecular marker of lung cancer diagnosis and treatment, has the advantages of convenience, rapidness, little damage, and easy reexamination, can be easily accepted by the patients, has an important meaning for the clinical diagnosis and treatment of lung cancer, and has a wide application prospect.
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Description

technical field

[0001] The invention belongs to the field of medical molecular biology and relates to a lung cancer marker TREM-2 and its application. Background technique

[0002] Lung cancer is one of the most common malignant tumors, and its mortality rate ranks first in the world and in my country. The 2012 GLOBOCAN cancer report shows that the incidence and death of lung cancer accounted for 12.9% and 19.4% of the total number of cancer cases and deaths in that year, respectively. In 2013, there were 220,000 new lung cancer patients in the United States, and the proportion of cancer patients who died of lung cancer increased significantly (26% for men and 28% for women). In recent years, the prognosis of lung cancer patients has been improved by adopting comprehensive treatment measures combining surgery, chemotherapy, radiotherapy and targeted therapy. However, due to the lack of specific symptoms in the early stage of such patients, most of them have already reached...

Claims

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