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A kind of hydrophilic modification method of polystyrene material and product thereof

A polystyrene-based, hydrophilic modification technology, applied in the field of polymer material modification, can solve the problems of difficulty in hydrophilic modification, inconspicuous shielding of non-specific adsorption, and difficulty in modification and further grafting. achieve the effect of reducing hydrophobicity

Active Publication Date: 2019-03-19
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For polystyrene microspheres with a cross-linking agent greater than 20%, especially a cross-linking agent greater than 55%, with a high degree of cross-linking or even an ultra-high degree of cross-linking, because it is difficult to swell and due to the small pore size, the Friedel-Crafts reaction on the benzene ring The substitution position can only be carried out on the surface of the microsphere, and the steric hindrance effect makes it difficult for the modification and further grafting to penetrate into the interior of the microsphere, and the hydrophilic modification is difficult (Li Q et al.In situ inhibitor removal promoted heterogeneous Friedel-Craftsreaction of polystyrene microsphere with Lewis acids catalysts.Journal ofMolecular Catalysis A Chemical.2013,370:56-63), the degree of non-specific adsorption is not obvious

Method used

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  • A kind of hydrophilic modification method of polystyrene material and product thereof
  • A kind of hydrophilic modification method of polystyrene material and product thereof
  • A kind of hydrophilic modification method of polystyrene material and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1 Preparation of polystyrene (PSt) microspheres

[0080] After mixing 2g methyl styrene (MST), 2g styrene and 1g divinylbenzene (DVB), add 2g n-heptane (HP) and 0.3g dibenzoyl peroxide (BPO) to dissolve Later as the dispersed phase. In 100 mL of deionized water, 2 g of polyvinyl alcohol (PVA) and 0.0015 g of dodecyl sulphuric acid (SDS) were added and dissolved as a continuous phase. Use conventional membrane emulsification technology (3.5μm membrane pores) to uniformly disperse the dispersed phase in the continuous phase to form a uniform oil / water emulsion. Then the prepared emulsion was moved into a reactor with a condenser, a stirring rod, and a nitrogen conduit, and after the oxygen was replaced by nitrogen, the polymerization reaction was carried out at 70° C. for 10 hours to obtain a microsphere polymerization suspension. After the polymerization, the microsphere product was obtained by suction filtration with a Buchner funnel. After repeated washing wit...

Embodiment 2

[0081] Example 2 Preparation of polystyrene (PSt) microspheres Prepare

[0082] Weigh 10g ethyl styrene (EST), 10g divinylbenzene (DVB), 0.5g potassium persulfate (KPS) and mix and dissolve as the oil phase; add 1.9g PVA, 0.0001g SDS and 0.0045 to 150mL deionized water g Na 2 SO 4 After being completely dissolved, it is used as the water phase. Using rapid membrane emulsification technology (membrane pores of 2.8μm), the oil-water phase mixture was quickly pressed through the microporous membrane tube and circulated and emulsified 4 times to obtain a uniform emulsion. Then the prepared emulsion was moved into a reactor equipped with a condenser, a stirring rod, and a nitrogen conduit. After the oxygen was replaced by nitrogen, the polymerization reaction was carried out at 85° C. for 20 hours to obtain a microsphere polymerization suspension. After the polymerization, the microsphere product was obtained by centrifugation at 8000 rpm with a centrifuge. After repeated centrifug...

Embodiment 3

[0083] Example 3 Preparation of polystyrene (PSt) microspheres

[0084] Weigh 4.5g of styrene (St), 5.5g of DVB, 0.28g of azoamidine (V65), 3g of hexadecane (HD) and 3g of n-hexanol (HA), mixed and dissolved as the oil phase; add 300mL of deionized water 3.5g PVA, 0.0008g SDS and 0.009gNa 2 SO 4 After being completely dissolved, it is used as the water phase. Using conventional membrane emulsification technology (membrane pores of 5.2 μm), the oil phase is evenly dispersed in the water phase to form a uniform oil / water emulsion. Then the prepared emulsion was moved into a reactor with a condenser, a stirring rod, and a nitrogen conduit, and after oxygen was replaced by nitrogen, the polymerization reaction was carried out at 80° C. for 20 hours to obtain a microsphere polymerization suspension. After the polymerization, the microsphere product was obtained by suction filtration with a Buchner funnel. After repeated washing with deionized water and ethanol, the product is dried...

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Abstract

The invention provides a hydrophilic modification method of a polystyrene material and a product thereof. The method includes the steps that hydrophilic modification is carried out on aromatic nucleuses and residual vinyl double bonds contained in the polystyrene material with the cross linking degree being 20% or above, so that hydrophilic modified polystyrene material is obtained. The method can achieve hydrophilic modification for the hydrophobic aromatic nucleuses and the residual vinyl double bonds inside the polystyrene material and on the surface of the polystyrene material, so that the hydrophobicity of the polystyrene material is substantially lowered. A nitration reaction, a reduction reaction and a reaction of coupled hydrophilic groups are utilized for carrying out hydrophilic modification on the aromatic nucleuses, in this way, the defect that internal modification is difficult to carry out on the polystyrene material with the high cross linking degree through an Friedel-Crafts reaction is overcome, and the obtained product after hydrophilic modification can be used as a biochemical separation medium under various separation modes and has good application prospects and advantages in the field of biochemical separation and purification.

Description

Technical field [0001] The invention relates to the technical field of polymer material modification, in particular to a method for hydrophilic modification of polystyrene materials and products thereof. Background technique [0002] Polystyrene (PSt) microspheres have the advantages of stable chemical properties, pH tolerance, and pressure tolerance, and are widely used in the separation and purification process of biochemical molecules. However, the characteristics of unmodified PSt materials severely limit its application fields. For example, PSt microspheres cannot be used directly as a chromatographic medium to separate protein and biological macromolecules except for reversed-phase chromatography. The reason is that the surface of PSt microspheres lacks functional groups, and it is difficult to directly couple with hydrophilic ligands; in addition, the strong hydrophobic interaction between the surface of PSt microspheres and protein molecules often causes irreversible prot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/36C08F212/08C08F212/12C08F8/44
CPCC08F8/44C08F212/08C08F212/12C08F212/36
Inventor 马光辉李强巩方玲黄永东赵岚
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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