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Hydrophilic modification method of polystyrene material and product thereof

A polystyrene-based, hydrophilic modification technology, which is applied in the field of polymer material modification, can solve problems such as the difficulty of hydrophilic modification, the difficulty of deep modification and further grafting, and the non-obvious shielding of non-specific adsorption. To achieve the effect of reducing hydrophobicity

Active Publication Date: 2017-04-26
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] For polystyrene microspheres with a cross-linking agent greater than 20%, especially a cross-linking agent greater than 55%, with a high degree of cross-linking or even an ultra-high degree of cross-linking, because it is difficult to swell and due to the small pore size, the Friedel-Crafts reaction on the benzene ring The substitution position can only be carried out on the surface of the microspheres, and the steric hindrance effect makes it difficult for the modification and further grafting to penetrate into the interior of the microspheres, and the hydrophilic modification is difficult (Li Q et al.In situ inhibitor removal promoted heterogeneous Friedel-Crafts reaction of polystyrene microsphere with Lewis acidscatalysts.Journal of Molecular Catalysis A Chemical.2013,370:56-63), the degree of non-specific adsorption is not obvious

Method used

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  • Hydrophilic modification method of polystyrene material and product thereof
  • Hydrophilic modification method of polystyrene material and product thereof
  • Hydrophilic modification method of polystyrene material and product thereof

Examples

Experimental program
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Embodiment 1

[0079] The preparation of embodiment 1 polystyrene (PSt) microspheres

[0080] After mixing 2g of methylstyrene (MST), 2g of styrene, and 1g of divinylbenzene (DVB), add 2g of n-heptane (HP) and 0.3g of benzoyl peroxide (BPO) as pore-forming agents to dissolve as the dispersed phase. Add 2 g of polyvinyl alcohol (PVA) and 0.0015 g of dodecylsulfuric acid (SDS) into 100 mL of deionized water and dissolve it as the continuous phase. Utilize conventional membrane emulsification technology (3.5μm membrane pores) to uniformly disperse the dispersed phase in the continuous phase to form a uniform oil / water emulsion. Then the prepared emulsion was moved into a reactor equipped with a condenser tube, a stirring rod, and a nitrogen conduit, and after replacing oxygen with nitrogen, the microsphere polymerization suspension was obtained after polymerization at 70° C. for 10 h. After the polymerization, the microsphere product was obtained by suction filtration with a Buchner funnel....

Embodiment 2

[0081] The system of embodiment 2 polystyrene (PSt) microspheres prepare

[0082] Weigh 10g of ethylstyrene (EST), 10g of divinylbenzene (DVB), 0.5g of potassium persulfate (KPS) and mix and dissolve it as the oil phase; add 1.9g of PVA, 0.0001g of SDS and 0.0045 g Na 2 SO 4 Completely dissolved as the water phase. Using rapid membrane emulsification technology (2.8 μm membrane pores), the oil-water phase mixture was quickly pressed through the microporous membrane tube and circulated for 4 times to obtain a uniform emulsion. Then the prepared emulsion was moved into a reactor equipped with a condenser tube, a stirring rod, and a nitrogen conduit, and after replacing oxygen with nitrogen, the microsphere polymerization suspension was obtained after a polymerization reaction at 85° C. for 20 h. After the polymerization, centrifuge at 8000rpm with a centrifuge to obtain the microsphere product. After repeated centrifugation and washing with deionized water and ethanol, the...

Embodiment 3

[0083] The preparation of embodiment 3 polystyrene (PSt) microspheres

[0084] Weigh 4.5g styrene (St), 5.5g DVB, 0.28g azoamidine (V65), 3g hexadecane (HD) and 3g n-hexanol (HA) and mix and dissolve them as the oil phase; 3.5g PVA, 0.0008g SDS and 0.009g Na 2 SO 4 Completely dissolved as the water phase. Using conventional membrane emulsification technology (5.2μm membrane pores), the oil phase is uniformly dispersed in the water phase to form a uniform oil / water emulsion. Then the prepared emulsion was moved into a reactor equipped with a condenser tube, a stirring rod, and a nitrogen conduit, and after replacing oxygen with nitrogen, the microsphere polymerization suspension was obtained after a polymerization reaction at 80° C. for 20 h. After the polymerization, the microsphere product was obtained by suction filtration with a Buchner funnel. After repeated washing with deionized water and ethanol, the product is dried in a vacuum oven to obtain highly cross-linked ...

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Abstract

The invention provides a hydrophilic modification method of a polystyrene material and a product thereof. The method includes the steps that hydrophilic modification is carried out on aromatic nucleuses and residual vinyl double bonds contained in the polystyrene material with the cross linking degree being 20% or above, so that hydrophilic modified polystyrene material is obtained. The method can achieve hydrophilic modification for the hydrophobic aromatic nucleuses and the residual vinyl double bonds inside the polystyrene material and on the surface of the polystyrene material, so that the hydrophobicity of the polystyrene material is substantially lowered. A nitration reaction, a reduction reaction and a reaction of coupled hydrophilic groups are utilized for carrying out hydrophilic modification on the aromatic nucleuses, in this way, the defect that internal modification is difficult to carry out on the polystyrene material with the high cross linking degree through an Friedel-Crafts reaction is overcome, and the obtained product after hydrophilic modification can be used as a biochemical separation medium under various separation modes and has good application prospects and advantages in the field of biochemical separation and purification.

Description

technical field [0001] The invention relates to the technical field of polymer material modification, in particular to a method for hydrophilic modification of polystyrene materials and a product thereof. Background technique [0002] Polystyrene (PSt) microspheres have the advantages of stable chemical properties, pH tolerance, and pressure tolerance, and are widely used in the separation and purification of biochemical molecules. However, the characteristics of unmodified PSt materials severely limit its application fields. For example, PSt microspheres cannot be directly used as chromatographic media to separate protein biomacromolecules except for reversed-phase chromatography. The reason is that the surface of PSt microspheres lacks functional groups, and it is difficult to directly couple hydrophilic ligands; in addition, the strong hydrophobic interaction between the surface of PSt microspheres and protein molecules often causes irreversible adsorption or even denatur...

Claims

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Application Information

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IPC IPC(8): C08F212/36C08F212/08C08F212/12C08F8/44
CPCC08F8/44C08F212/08C08F212/12C08F212/36
Inventor 马光辉李强巩方玲黄永东赵岚
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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