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Medicine with resistance to staphylococcus aureus as well as preparation method and application of medicine

A staphylococcus, golden yellow technology, applied in the field of biomedicine, can solve problems such as large dosage of antibiotics, and achieve the effects of improving sensitivity, reducing dosage, and reducing adverse reactions of drug-induced hematuria

Inactive Publication Date: 2017-05-10
SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no synergistic effect was found between the traditional Chinese medicine composition and the antibiotics in this medicine, and the dosage of antibiotics in this medicine was too large, and the ratio of it to the total dosage of the Chinese medicine composition was as high as 1:(43~430)

Method used

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  • Medicine with resistance to staphylococcus aureus as well as preparation method and application of medicine
  • Medicine with resistance to staphylococcus aureus as well as preparation method and application of medicine
  • Medicine with resistance to staphylococcus aureus as well as preparation method and application of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, the preparation of anti-staphylococcus aureus drug oral liquid

[0034] honeysuckle 7.35mg Scutellaria baicalensis 7.35mg forsythia 14.7mg Cefradine 3μg

[0035] Preparation:

[0036] A) Preparation of traditional Chinese medicine composition: take honeysuckle, scutellaria baicalensis and forsythia, wash, dry, crush into coarse powder, add 5 times the amount of coarse powder in purified water, soak for 12 hours, decoct twice, combine the decoction, and filter , the filtrate is concentrated into a concentrated solution of 20ml;

[0037] B) Add cephradine to the above-mentioned concentrated solution, mix evenly, pack in 10ml / cartridge, and sterilize to get final product.

Embodiment 2

[0038] Embodiment 2, the preparation of anti-staphylococcus aureus drug oral liquid

[0039]

[0040]

[0041] The preparation method is as in Example 1.

Embodiment 3

[0042] Embodiment 3, the preparation of anti-staphylococcus aureus drug oral liquid

[0043] honeysuckle 7.35mg Scutellaria baicalensis 7.35mg forsythia 14.7mg Cefradine 12μg

[0044] The preparation method is as in Example 1.

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Abstract

The invention belongs to the field of biological medicines and particularly relates to a medicine with resistance to staphylococcus aureus as well as a preparation method and application of the medicine. The medicine with resistance to staphylococcus aureus comprises a traditional Chinese medicine composition and antibiotics, wherein the traditional Chinese medicine composition is prepared from flos lonicerae, radix scutellariae and fructus forsythiae according to a weight ratio of 1 to (0.1-1) to (0.5-2); the antibiotics are selected from one of cefradine, levofloxacin and gentamicin. With combination of the traditional Chinese medicine composition and the antibiotics, the sensibility to antibiotics of staphylococcus aureus can be improved; the medicine resistance is difficultly generated when frequently taking the medicine; meanwhile, the dosage of the antibiotics can be effectively reduced; the occurrence of adverse effect of medicinal hematuria can be reduced; the medicine has a good application prospect; the invention further provides application of the medicine with resistance to staphylococcus aureus to preparation of medicines or antibacterial products.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug against Staphylococcus aureus, a preparation method and application. Background technique [0002] Staphylococcus aureus is a common colonization bacterium on human skin and nasal cavity, and it is also a common pathogenic bacterium that causes clinical infections. It can cause local suppurative infections, such as carbuncles, furuncles, folliculitis, paronychia, and surgical incisions. Sexual infection, but also pneumonia, osteomyelitis, meningitis, septic arthritis, endocarditis, sepsis, sepsis and other systemic infections. [0003] With the widespread use of antibiotics in clinical practice, drug-resistant strains of Staphylococcus aureus are emerging. The acquisition of drug resistance of Staphylococcus aureus, on the one hand, can produce adaptive resistance to antibiotics through changes in the phenotype of the bacteria itself, adjustment of metabolic pathway...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61P31/04A61K31/545A61K31/5383A61K31/7036
CPCA61K36/634A61K31/5383A61K31/545A61K31/7036A61K36/355A61K36/539A61K2236/331A61K2236/39A61K2300/00
Inventor 刘广锋
Owner SOUTH CHINA SEA FISHERIES RES INST CHINESE ACAD OF FISHERY SCI
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