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A kind of pharmaceutical composition for treating hypertension and its preparation method and application

A composition and high blood pressure technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems such as the curative effect needs to be improved, and achieve the effect of precise formula and good application prospect

Active Publication Date: 2020-06-19
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Li Mingmao et al., "Analysis of the compliance rate of modified Evodia rutaecarpa Decoction in the treatment of patients with hypertension", Chengdu University of Traditional Chinese Medicine, Volume 31, Issue 1, March 2008, disclosed the drugs for treating hypertension: 4g of Evodia rutaecarpa, 25g of Codonopsis pilosula, 15g of jujube , Ginger 10g, Cassia 30g, Gastrodia elata 10g, Scutellaria baicalensis 10g, Prunella vulgaris 15g, Angelica 12g, Salvia miltiorrhiza 30g, but its curative effect needs to be improved

Method used

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  • A kind of pharmaceutical composition for treating hypertension and its preparation method and application

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Embodiment 1

[0032] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0033] Take Evodia 4g, Codonopsis 15g, Jujube 12g, Gastrodia elata 15g, Uncaria 15g, Shicasia 30g, Scutellaria baicalensis 15g, Prunella vulgaris 20g, Angelica 12g, Salvia miltiorrhiza 20g, Inula 15g, Ocher 20g, Tongcao 10g, Turmeric 10g, licorice 3g.

[0034] Preparation method: add water to decoct the above 15 flavors three times, each time add 10 times the amount of medicinal materials, decoct for 1 hour, combine the decoction, filter, concentrate, and get ready.

Embodiment 2

[0035] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0036] Evodia 10g, Codonopsis 20g, Jujube 10g, Gastrodia elata 10g, Uncaria 10g, Cassia 20g, Scutellaria baicalensis 10g, Prunella vulgaris 10g, Angelica 10g, Salvia miltiorrhiza 15g, Inula 10g, Ocher 15g, Tongcao 10g, Curcuma 10g , licorice 6g.

[0037] Preparation method: decoct the above 15 flavors with water three times, each time adding 10 times the amount of medicinal materials, decocting for 1 hour, combining the decoction, filtering, and concentrating the filtrate to a thick paste with a relative density of 1.2 (40°C), Mix well, dry under reduced pressure (50~60℃, -0.08~-0.09Mpa), grind into fine powder (pass through a No. 5 sieve, 80 mesh), add dextrin, mix well, and make granules by wet method, that is, .

Embodiment 3

[0038] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0039] Evodia 20g, Codonopsis 10g, Jujube 20g, Gastrodia elata 30g, Uncaria 20g, Cassia 60g, Scutellaria baicalensis 30g, Prunella vulgaris 30g, Angelica 20g, Salvia miltiorrhiza 40g, Inula 20g, Ocher 30g, Tongcao 20g, Curcuma 15g , licorice 3g.

[0040] Preparation method: replace the above 15 ingredients with ocher and cassia and crush them into fine powder (through a No. 5 sieve, 80 mesh), and set aside; take the remaining medicinal materials and add water to decoct three times. After 1 hour, combine the decoctions, filter, and concentrate the filtrate to an extract with a relative density of 1.1 (40°C), add ochre and cassia powder, and make pellets to obtain.

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Abstract

The invention discloses a pharmaceutical composition for treating hypertension, which is a preparation prepared from raw materials in the following weight ratio: 4-20 parts of Evodia rutaecarpa, 10-30 parts of Codonopsis pilosula, 10-30 parts of Chinese jujube, gastrodia elata 10-30 parts, Uncaria 10-30 parts, Cassia 20-60 parts, Scutellaria baicalensis 10-30 parts, Prunella vulgaris 10-30 parts, Angelica 10-20 parts, Salvia miltiorrhiza 15-40 parts, Inula 10-30 parts 30 parts, 15-30 parts of ochre, 10-20 parts of Tongcao, 10-20 parts of turmeric, 3-15 parts of licorice. The pharmaceutical composition of the invention can effectively treat hypertension, and has good clinical application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hypertension, its preparation method and application. Background technique [0002] Hypertension (hypertension) refers to an increase in systemic arterial blood pressure (systolic and / or diastolic) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney, etc. Clinical syndrome of functional or organic damage to organs. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range with changes in the internal and external environment. In the whole population, the blood pressure level gradually increases with age, especially the systolic blood pressure, but the diastolic blood pressure shows a downward trend after the age of 50, and the pulse pressure also increases acc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P9/12A61K35/618A61K33/26
CPCA61K33/26A61K35/618A61K36/232A61K36/25A61K36/28A61K36/344A61K36/484A61K36/536A61K36/537A61K36/539A61K36/725A61K36/74A61K36/754A61K36/8988A61K36/9066A61K2300/00
Inventor 宋军李明懋杨金蓉鄢良春
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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