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Combined application of statins and corticosteroids in the treatment of chronic subdural hematoma

A technology of adrenal cortex and glucocorticoids, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of chronic subdural hematoma with long cycle and patient complications, and achieve broad application prospects and Clinical significance, shortening of treatment period, effect of avoiding pain

Active Publication Date: 2018-05-11
张建宁 +2
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Problems solved by technology

[0007] The purpose of the present invention is to solve the long period of clinical use of statins in the treatment of chronic subdural hematoma, and to overcome the technical prejudice of those skilled in the art on the amount of hormone used, and the use of high-dose hormones brings a large number of complications to patients, etc. question

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  • Combined application of statins and corticosteroids in the treatment of chronic subdural hematoma
  • Combined application of statins and corticosteroids in the treatment of chronic subdural hematoma
  • Combined application of statins and corticosteroids in the treatment of chronic subdural hematoma

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Embodiment Construction

[0057] In order to further explain the technical solution of the present invention and the technical effects achieved by it, the present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0058] 1. Low-dose atorvastatin promotes the absorption of subdural hematoma

[0059] By improving the subdural model of rats, and according to different doses of oral atorvastatin, the experimental animals were divided into 3 groups: control group, low dose group (3mg / kg / day, equivalent to 10-20mg / day for adults) ) and high-dose group (8mg / kg / day, equivalent to 80-100mg / day for adults). The dynamic changes of hematoma volume in rats were observed by MRI. HE staining, transmission electron microscopy, immunohistochemistry, flow cytometry, real-time quantitative PCR, and ELISA were used to measure the physiological structure characteristics of neohematoma capsule disease, the number of peripheral blood endothelial progenitor cells, new b...

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Abstract

The invention discloses the use of a statin drug combined with an adrenocortical hormone drug in the preparation of a drug for treating chronic subdural hematoma. The drug combination of the present invention can significantly accelerate the absorption of hematoma, greatly improves the therapeutic effect of oral statins alone, without other side effects, and the adrenal cortex hormones used in the present invention are 1 / 10 of the high-dose hormone therapy, which is greatly improved. The incidence rate of related complications caused by hormone therapy is reduced, and the technical solution of drug combination of the present invention has good therapeutic effect, and has broad application prospects and clinical significance.

Description

technical field [0001] The invention belongs to the field of medical preparations containing active ingredients, and in particular relates to the combined application of statins, dexamethasone and structural analogues thereof in the treatment of chronic subdural hematoma. Background technique [0002] People have been exploring and researching chronic subdural hematoma (CSDH) for more than a century, and the earliest can be traced back to more than 150 years ago. According to literature records, it was Virchow who first proposed the study on the mechanism of chronic subdural hematoma formation. He first described the disease in 1857 and put forward the hypothesis that inflammatory hemorrhage in the inner dura mater is the cause of CSDH, namely: Pachymeningitis Theory. Later, a series of studies such as pathological detection and electron microscope observation found that the capsule of chronic subdural hematoma contained a large number of abnormal sinus-shaped lacunar blood ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/573A61K31/40A61P25/00
CPCA61K31/40A61K31/573A61K45/06A61K2300/00A61K31/366A61K31/505A61P25/00
Inventor 张建宁江荣才王东权伟
Owner 张建宁
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