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Method and system for assessing tumor load change

A tumor and burden technology, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the lack of objective evaluation system, lack of flexibility in evaluation time nodes, lack of accurate evaluation of biological activity inside tumor cells, etc. question

Active Publication Date: 2017-05-31
BEIJING GENEPLUS TECH +1
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Problems solved by technology

[0004] Imaging methods have the following three problems (Sharma M R, Maitland M L, Ratain MJ. RECIST: no longer the sharpest tool in the oncology clinical trials toolbox—point. Cancer research, 2012, 72(20): 5145-5149; Tie J, Kinde I, Wang Y, etal. Circulating tumor DNA as an early marker of therapeutic response inpatients with metastatic colorectal cancer. Annals of Oncology. 2015; 26(8):1715-1722): (1) This method mainly uses Imaging evaluation of the external shape and size of the tumor lacks an accurate assessment of the internal biological activity of tumor cells; (2) This method lacks an objective evaluation system for non-measurable lesions, such as pleural effusions and peritoneal effusions; (3) The time node used for clinical evaluation by this method is usually fixed at 6-8 weeks during the treatment process, or every 3-4 months after treatment, lacking the flexibility of the evaluation time node

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  • Method and system for assessing tumor load change
  • Method and system for assessing tumor load change
  • Method and system for assessing tumor load change

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Embodiment

[0199] In the following, the present invention will be described through the specific example of detection results of plasma free DNA in patients with peritoneal metastasis of breast cancer. It should be noted that this example is only for the purpose of illustration, and cannot be interpreted as a limitation of the present application in any way.

[0200] 1. Peripheral plasma separation and free DNA extraction:

[0201] Use EDTA anticoagulant tubes for blood collection instead of heparin anticoagulation. The amount of blood collected should not be less than 8ml. Immediately after blood collection, the blood should be mixed upside down, and the plasma separation should be completed within 4 hours.

[0202] 1.1 Plasma separation process: (1) Centrifuge the blood collection tube at 1600g for 10 minutes at 4°C. After centrifugation, divide the upper layer of plasma into multiple 1.5mL or 2.0mL centrifuge tubes. During the process of absorbing plasma, no intermediate white blood c...

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Abstract

The invention discloses a method and system for assessing tumor load change. The method can accurately and flexibly assess a tumor load and provide molecular biological characteristics of tumor cells. In the method, detection samples are free DNA samples at a plurality of time nodes, free DNA variation is detected, a molecular tumor load index is calculated according to the frequency of variation, and the change trends of the molecular tumor load index are compared at a plurality of time nodes so as to reflect the change trend of the tumor load.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more particularly the invention relates to methods and systems for assessing tumor burden. Background technique [0002] Tumor burden refers to the number of tumor cells, tumor size or the number of tumor lesions in the body, and is usually used to indicate the degree of harm of the tumor to the human body. Accurate assessment of changes in tumor burden is the key to evaluating the clinical efficacy of tumor drugs. [0003] At present, imaging methods are usually used clinically to evaluate advanced tumor burden. The implementation of this method needs to follow the RECIST1.1 standard (Eisenhauer E A, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). European journal of cancer, 2009, 45(2): 228-247), according to the changes of target lesions observed in imaging studies of tumor patients during treatment, the efficacy and tu...

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Application Information

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IPC IPC(8): G06F19/20G06F19/22G06F19/24G06F19/00
Inventor 管彦芳常连鹏刘涛吴爱伟李盼松易鑫杨玲
Owner BEIJING GENEPLUS TECH
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