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Application of robinin-7-O-glucuronide

A technology of glucuronide and acacia can be applied in the field of medicine and can solve problems such as clinical application limitation and the like

Inactive Publication Date: 2017-06-13
石河子大学医学院第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an endogenous protective mechanism, IPC has certain clinical value, but its clinical application is limited due to many reasons such as ethics and inconvenient use.

Method used

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  • Application of robinin-7-O-glucuronide
  • Application of robinin-7-O-glucuronide
  • Application of robinin-7-O-glucuronide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] The object of the present invention is the purposes of locustine-7-O-glucuronide:

[0143] The application of the invention is that the locustin-7-O-glucuronide has cardioprotective activity, and the compound can be used as a lead compound for cardioprotection. To elucidate the protective effect and mechanism of locustin-7-O-glucuronide against myocardial ischemia-reperfusion injury from the whole animal and cytokine levels.

Embodiment 2

[0145] The object of the present invention is the purposes of locustine-7-O-glucuronide:

[0146] The application of the invention is that the locustin-7-O-glucuronide has cardioprotective activity, and the compound can be used as a lead compound for cardioprotection.

[0147] A. Locustin-7-O-glucuronide can inhibit the degree of myocardial infarction and the release of serum myocardial enzymes in rats;

[0148] B. Locustin-7-O-glucuronide relieves acute myocardial infarction by correcting energy metabolism disorder in the process of acute myocardial ischemia-reperfusion injury, inhibiting oxidative damage, inflammatory factor activation and neutrophil infiltration. During blood reperfusion injury, endothelial dysfunction, regulating the expression of apoptotic active genes, and inhibiting apoptosis play a role in anti-acute myocardial ischemia-reperfusion injury.

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Abstract

The invention discloses application of robinin-7-O-glucuronide. A compound has cardioprotective effect activity, so that the robinin-7-O-glucuronide can be used as a lead compound with a cardioprotective effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the new application of locustine-7-O-glucuronide. Background technique [0002] Myocardial ischemia-reperfusion injury (Myocardial ischemia-reperfusion injury, MIRI) refers to the recovery of blood supply after a short-term interruption of myocardial blood supply for a certain period of time. Not even irreversible. At present, in the treatment of ischemic heart disease, MIRI is the main problem that hinders the best curative effect of the disease, weakens the original intention of treatment to a large extent, and causes many patients to suffer more serious physical injuries and economic losses. Therefore, it is imperative to find an effective method to achieve blood reperfusion while at the same time reducing reperfusion injury, and elucidating the mechanism of MIRI is the basic premise for fundamentally preventing and treating such diseases. [0003] After years o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/10A61P29/00A61P9/00A61P9/12A61P1/08A61P25/00
CPCA61K31/7048C07H1/08C07H17/07
Inventor 王新春袁勇邢建国王晓义陈卫军李静秦冬梅
Owner 石河子大学医学院第一附属医院
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