Dual-response multiple-medicine delivery system based on cyclodextrin

A transmission system and dual response technology, applied in the field of material science, can solve the problems of causing side effects, unable to achieve multiple drug delivery, unable to accurately control the release of drug doses, etc., and achieve the effect of simple and convenient operation.

Inactive Publication Date: 2017-06-30
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In most research systems, multiple drugs cannot be delivered together, and some drugs will be released before reaching the delivery site, causing side effects, and the dose of released drugs cannot be accurately controlled

Method used

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  • Dual-response multiple-medicine delivery system based on cyclodextrin
  • Dual-response multiple-medicine delivery system based on cyclodextrin
  • Dual-response multiple-medicine delivery system based on cyclodextrin

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Effect test

Embodiment 1

[0045] A preparation method of a cyclodextrin-based dual-response multi-drug delivery system of the present invention, the steps are as follows:

[0046] 1. Preparation of Mesoporous Silica Microspheres MCM-41

[0047] Cetyltrimethylammonium bromide (CTAB, 0.5g), NaOH solution (2mol / L, 1.75mL) and H 2 O (240 mL) was mixed and stirred at 80 °C for 30 min. Ethyl orthosilicate (TEOS, 2.5 mL) was added dropwise, and a white precipitate was formed after thorough stirring for 10 min. Stir at 80°C for 2h, filter while hot, wash the product thoroughly with water and methanol, and dry it in vacuum at 90°C.

[0048] Weigh 0.3g of dry solid, ultrasonically disperse in a mixed solution of isopropanol (60mL) and concentrated hydrochloric acid (3mL), heat to reflux for 6h, centrifuge, wash thoroughly with water and methanol, and dry under vacuum at 90°C to obtain mesoporous silica Microspheres (MCM-41).

[0049] 2. Preparation of 2-bromo-ethoxy-2-azido-ethoxypropane

[0050] Dissolve 1...

Embodiment 2

[0066] The present invention is a kind of preparation method of cyclodextrin-based pH-stimulus response type intelligent nano-container, and the steps are as follows:

[0067] 1. Preparation of Mesoporous Silica Microspheres MCM-41

[0068] Cetyltrimethylammonium bromide (CTAB, 0.5g), NaOH solution (2mol / L, 1.75mL) and H 2 O (240 mL) was mixed and stirred at 80 °C for 30 min. Ethyl orthosilicate (TEOS, 2.5 mL) was added dropwise, and a white precipitate was formed after thorough stirring for 10 min. Stir at 80°C for 2h, filter while hot, wash the product thoroughly with water and methanol, and dry it in vacuum at 90°C.

[0069] Weigh 0.3g of dry solid, ultrasonically disperse in a mixed solution of isopropanol (60mL) and concentrated hydrochloric acid (3mL), heat to reflux for 6h, centrifuge, wash thoroughly with water and methanol, and dry under vacuum at 90°C to obtain mesoporous silica Microspheres (MCM-41).

[0070] 2. Preparation of 2-bromo-ethoxy-2-azido-ethoxypropan...

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Abstract

The invention discloses a dual-response multiple-medicine delivery system based on cyclodextrin. Firstly, through the action of a donor and a receptor, a macrocyclic molecule cyclodextrin serving as a host and a molecule ferrocene group serving as a guest form a self-inclusion complex; the dissociation and the inclusion of the host to the guest can be realized by utilizing redox regulation and control; the effect that a micromolecular medicine is subjected to adsorption-release through a cavity of the cyclodextrin is realized; secondly, a carbon chain containing an acetal group is introduced to connect a derivative of the cyclodextrin and a silicon dioxide microsphere; in an acid environment, an acetal bond is ruptured; the derivative of the cyclodextrin is quitted; a macromolecule is further released. The medicine delivery system provided by the invention has the characteristics of redox and dual response in the acid environment, moreover, can be used for seriatim or synchronously releasing medicine molecules in different sizes, can be used for controlling administration time, a position and a dosage, and has a favorable application prospect.

Description

technical field [0001] The invention belongs to the technical field of material science, in particular to a cyclodextrin-based dual-response multi-drug delivery system. Background technique [0002] Chemotherapy is a treatment method that uses chemical drugs to prevent the proliferation, invasion, and metastasis of cancer cells, and finally kill cancer cells. It is a systemic treatment method, together with surgery and radiotherapy, and is called the three major treatment methods for cancer. However, due to the low selectivity of chemotherapeutic drugs, it will inevitably damage the normal cells of the human body when killing cancer cells, resulting in adverse drug reactions and prone to problems such as drug resistance. In order to solve the above problems, multiple drug delivery systems have emerged, which can inhibit drug resistance, produce synergistic effects, and better kill cancer cells. [0003] In most research systems, multiple drugs cannot be administered togeth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K9/14A61K31/192A61K31/704C08B37/16
CPCA61K9/146A61K31/192A61K31/704C08B37/0015A61K2300/00
Inventor 傅佳骏王婷孙广平宫光彩
Owner NANJING UNIV OF SCI & TECH
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