Calcium polycarbophil chewable tablet and preparation method thereof

A technology of polycarbophil calcium and chewable tablets, which is applied in the directions of non-active ingredients medical preparations, pharmaceutical formulations, artificially synthesized active ingredients of polymeric materials, etc., can solve problems such as unpleasant gastrointestinal reactions and achieve stable effect, improvement of treatment effect, effect of stable quality

Inactive Publication Date: 2017-07-04
SHENZHEN FONCOO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the addition of surfactants, it is easy to cause uncomfortable gastrointestinal reactions

Method used

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  • Calcium polycarbophil chewable tablet and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0024] A polycarbophil calcium chewable tablet, its specific composition sees the weighing of the material in its following preparation method:

[0025] (1), weigh polycarbophil calcium 500g and carboxymethyl starch 100g, adopt the method dry mixing of increasing in equal amounts, after mixing;

[0026] (2) Weigh 50g of oat fiber, 25g of fructose and 25g of xylitol for pre-mixing. After mixing evenly, fully mix with the mixed powder of step (1), make large pieces and chop, repeat twice, and pass through a 60-mesh sieve ;

[0027] (3) After adding 1 g of sweetener and 1 g of lubricant, the polycarbophil calcium 500 mg tablet is prepared according to the specification.

Embodiment 2

[0029] A polycarbophil calcium chewable tablet, its specific composition sees the weighing of the material in its following preparation method:

[0030] (1), weigh polycarbophil calcium 500g and carboxymethyl starch 80g, adopt the method dry mixing of increasing in equal amounts, after mixing;

[0031] (2) Weigh 50g of oat fiber, 15g of fructose and 15g of xylitol for pre-mixing. After mixing evenly, fully mix with the mixed powder of step (1), make large pieces and chop, repeat twice, and pass through a 60-mesh sieve ;

[0032] (3) After adding 1 g of sweetener and 1 g of lubricant, the polycarbophil calcium 500 mg tablet is prepared according to the specification.

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Abstract

The invention discloses a calcium polycarbophil chewable tablet and a preparation method of the calcium polycarbophil chewable tablet. The chewable tablet contains calcium polycarbophil, carboxymethyl starch, oat fibers, fructose and newtol, as well as more than one other suitable auxiliary material. For the calcium polycarbophil chewable tablet, calcium polycarbophil and carboxymethyl starch are matched, so that the excessive expansion in the oral cavity is reduced, after entering the gastrointestinal tract, the calcium polycarbophil chewable tablet disintegrates rapidly and releases rapidly, and therefore, the problems that the swallowing of the chewable tablet in the prior art needs abundant water, and the taking is difficult are solved. The expansion of the carboxymethyl starch in the gastrointestinal tract serves as the good effects of the disintegrating agent, the effects of similar medicines are achieved, and the treatment effect for the irritable bowel syndrome is improved in a synergetic manner. The chewable tablet provided by the invention is stable in quality, the limited quantity of oligomer is low after the chewable tablet is stored for a long term, and thus the stable effect of the medicine is benefited.

Description

technical field [0001] The invention relates to the field of polycarbophil calcium pharmaceutical preparations, in particular to a polycarbophil calcium chewable tablet and a preparation method thereof. Background technique [0002] Irritable bowel syndrome is a disease that can cause abnormal defecation even in the absence of organic disorders, usually caused by functional abnormalities in the distal digestive tract, and can generally be divided into the following categories: spastic contraction of the terminal colon, etc. Constipation type caused by delayed delivery of contents; diarrhea type caused by increased peristalsis and other promotion of contents delivery; alternate type in which constipation and diarrhea are repeated sequentially. [0003] Polycarbophil is a cross-linked resin of polyacrylic acid and 3,4-diol-1,5-hexadiene. This resin has high water retention characteristics. Polycarbophil calcium salt polycarbophil calcium As medicinal. US Pat. No. 3,297,664 d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/78A61K47/36A61K47/46A61P1/10
CPCA61K9/0056A61K9/2059A61K31/78
Inventor 贾文强闫鹏钟东会
Owner SHENZHEN FONCOO PHARMACEUTICAL CO LTD
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