Method for preparing ferriccarboxymaltose

A technology of carboxymaltose iron and filter cake, which is applied in the field of preparation of carboxymaltose iron, can solve the problems of low absorption rate and large side effects, and achieve the effects of suitable molecular weight, strong oxidation ability and good oxidation effect

Inactive Publication Date: 2017-07-25
广州仁恒医药科技股份有限公司
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Problems solved by technology

Traditional iron supplements have disadvantages such as large side effects and low absorption rate

Method used

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  • Method for preparing ferriccarboxymaltose

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Embodiment Construction

[0024] In order for those skilled in the art to better understand the technical solutions provided by the present invention, the following will be described in conjunction with specific embodiments.

[0025] This case will be fully understood by the following examples, so that those skilled in the art can complete it, but the examples of this case cannot be limited by the following implementation types.

[0026] See figure 1 , this figure is the detection spectrum of the iron carboxy maltose product of the preparation method of iron carboxy maltose of the specific embodiment of the present invention.

[0027] The preparation method of the carboxyl maltose iron of the present embodiment is as follows:

[0028] Step 1. Oxidation:

[0029] Add 300mL of purified water to the reaction bottle at room temperature (15-30°C), add 200g of maltodextrin while stirring, then rinse the bottle wall material with 300mL of purified water, and stir for 30min until dissolved. Add 27.2 g of tr...

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Abstract

The invention discloses a method for preparing ferriccarboxymaltose, the ferriccarboxymaltose is prepared through five steps, selected reagents are green, environmentally friendly, and more suitable for industrial production, a selected oxidant system has strong oxidation capacity, product dispersion coefficient is proper, the molecular weight of the formed ferriccarboxymaltose is proper, and the formed ferriccarboxymaltose is high in Fe content.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a preparation method of carboxymaltose iron. Background technique [0002] Iron deficiency anemia is a common nutritional disease, and iron supplementation is an effective treatment for patients with iron deficiency anemia. Traditional iron supplements have disadvantages such as large side effects and low absorption rate. Since the 1990s, iron dextran has been widely used in the United States. Iron dextran is administered through intravenous infusion to treat iron deficiency anemia in patients with renal failure, avoiding the problems of gastrointestinal irritation and adverse digestion and absorption. [0003] The US FDA approved the marketing of the product (trade name: Injectafer) of AmeriCanRegen, a subsidiary of Luitpold Pharmaceuticals, for the treatment of iron deficiency anemia in adults who cannot tolerate oral iron or are ineffective in oral iron therapy. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02
CPCC08B37/0021
Inventor 田元周胜安郭斌许志国
Owner 广州仁恒医药科技股份有限公司
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