Tetrodotoxin pharmaceutical composition and externally-used medicine for treating pain diseases

A technology of tetrodotoxin and composition, which is applied in the field of new health care and pharmaceutical use of tetrodotoxin, can solve the problems of long duration, etc., and achieve the effects of convenient and simple usage, wide indications, pain relief or disappearance

Inactive Publication Date: 2017-09-26
东新皓特(北京)生化科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When used to treat neuralgia, it generally takes effect later than morphine and pethidine, but lasts longer, and the analgesic time can reach 12-20 hours

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 pharmaceutical composition:

[0047] A tetrodotoxin pharmaceutical composition for treating pain conditions, the medicine consists of:

[0048] Tetrodotoxin 200µg; Dandelion 5g;

[0049] Panax notoginseng 2g; Wang Buliuxing 20g;

[0050] Anise 10g; Cumin 10g;

[0051] Angelica dahurica 4g; Baiji 10g;

[0052] Sichuan pepper 5g; Chuanqiong 15g;

[0053] Speranth 5g; Wujiapi 10g;

[0054] Oregano 5g; Safflower 10g;

[0055] Musk 5g; Gastrodia elata 5g;

[0056] borneol 5g.

[0057] Preparation:

[0058] a: Weigh the prescribed amount of Panax notoginseng, Buliuxing, anise, cumin, Angelica dahurica, Bletilla striata, Zanthoxylum bungeanum, Chuanqiong, Sperancus, Wujiapi, oregano, safflower, Gastrodia elata, borneol, musk and Dandelion sixteen-flavor raw material medicine, add water and decoct 3 times, the amount of water added for the first time is 10 times of the total weight of the sixteen-flavor raw material medicine, and decocted for 3 hours; the ...

Embodiment 2

[0061] Embodiment 2 pharmaceutical composition:

[0062] A tetrodotoxin pharmaceutical composition for treating pain conditions, the medicine consists of:

[0063] Tetrodotoxin 1000µg; Dandelion 20g;

[0064] Panax notoginseng 20g; Wang Buliuxing 30g;

[0065] Anise 30g; Cumin 30g;

[0066] Angelica dahurica 20g; Baiji 20g;

[0067] Zanthoxylum bungeanum 10g; Chuanqiong 20g;

[0068] 15g Speranthum; Wujiapi 20g;

[0069] Oregano 10g; Safflower 30g;

[0070] borneol 10g; Gastrodia elata 10g;

[0071] Musk 10g.

[0072] The preparation method was prepared according to the method of Example 1.

[0073] It should be noted that the replacement of the pharmaceutical composition in this example with an equivalent amount of tetrodotoxin can also be implemented to achieve the expected effect, that is, only tetrodotoxin is needed when making the pharmaceutical composition, and no other traditional Chinese medicine raw materials are added.

Embodiment 3

[0074] Embodiment 3 pharmaceutical composition:

[0075] A tetrodotoxin pharmaceutical composition for treating pain conditions, the medicine consists of:

[0076] Tetrodotoxin 10µg; Dandelion 12g;

[0077] Panax notoginseng 11g; Wang Buliuxing 25g;

[0078] Anise 20g; Cumin 20g;

[0079] Angelica dahurica 12g; Baiji 15g;

[0080] Sichuan pepper 7g; Chuanqiong 18g;

[0081] 10g Speranthum; Wujiapi 15g;

[0082] oregano 7g; safflower 20g;

[0083] borneol 7g; Gastrodia elata 7g;

[0084] Musk 7g.

[0085] The preparation method was prepared according to the method of Example 1.

[0086] It should be noted that the replacement of the pharmaceutical composition in this example with an equivalent amount of tetrodotoxin can also be implemented to achieve the expected effect, that is, only tetrodotoxin is needed when making the pharmaceutical composition, and no other traditional Chinese medicine raw materials are added.

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PUM

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Abstract

The invention discloses a tetrodotoxin pharmaceutical composition for treating pain diseases. The tetrodotoxin pharmaceutical composition contains 1 to 1000mu g/unit dose of tetrodotoxin and/or a derivative of the tetrodotoxin and further is prepared from the following bulk drugs in weight: radix notoginseng, semen vaccariae, fructus anisi stellati, fructus foeniculi, radix angelicae dahuricae, rhizoma bletillae, pericarpium zanthoxyli, rhizoma chuanxiong, herba speranskiae tuberculatae, cortex acanthopanacis, origanum vulgare herb, flos cartham, rhizoma gastrodiae, borneol, musk and herba taraxaci. The invention further discloses a preparation method of the tetrodotoxin pharmaceutical composition for treating the pain diseases. The invention further discloses an externally-used medicine prepared from the tetrodotoxin pharmaceutical composition for treating the pain diseases. The externally-used medicine of the tetrodotoxin pharmaceutical composition disclosed by the invention has convenient and simple use method, avoids special instruments or devices, has no technical requirement, has controllable untoward effect and very wide adaptation diseases, is not only limited to treat various acute and chronic pain, but also has reliable analgesic effect and further can be applied to treating various of non-pain symptoms and diseases.

Description

technical field [0001] The present invention relates to the new health care and medicine application of tetrodotoxin, in particular to a tetrodotoxin pharmaceutical composition and external medicine for treating pain. Background technique [0002] Tetrodotoxin (TTX), also known as Spheroidin, is a marine toxin found in puffer fish, salamanders, spotted-footed toads and other animals. Toxins mainly exist in the gonads, liver, spleen, eyes, skin, blood and other parts of puffer fish. Tetrodotoxin is isolated from the ovary or liver of puffer fish. It is a non-protein small molecular compound. [0003] Over the past decades, foreign scholars have conducted a series of in-depth studies on TTX, and gained a lot of research on its unique chemical characteristics, pharmacological and toxicological effects, etc. The main pharmacological effect of TTX is to inhibit the Na+ influx of nerve cells, block Cut off the conduction of nerve excitation. It is a highly specific cell membra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/529A61K36/8988A61P29/00A61P25/00A61P23/00A61K31/045A61K35/55
CPCA61K31/529A61K9/0014A61K31/045A61K35/55A61K36/185A61K36/232A61K36/235A61K36/236A61K36/254A61K36/258A61K36/286A61K36/288A61K36/36A61K36/47A61K36/53A61K36/57A61K36/758A61K36/898A61K36/8988A61K2236/331A61K2236/39A61K2300/00
Inventor 刘延东刘皓
Owner 东新皓特(北京)生化科技有限公司
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