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Pharmaceutical composition for treating bovine mastitis and preparation method thereof

A technology of mastitis and composition, applied in the field of animal husbandry, can solve problems such as the easy production of antibiotic-resistant milk and human health hazards, and achieve the effects of improved bioavailability and less toxic and side effects

Inactive Publication Date: 2017-10-17
XIANYANG VOCATIONAL TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, antibiotic drugs have been widely used to treat dairy cow mastitis. Although they are effective, the large-scale use of such drugs is prone to drug resistance and the formation of antibiotic milk, causing potential harm to human health.

Method used

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  • Pharmaceutical composition for treating bovine mastitis and preparation method thereof
  • Pharmaceutical composition for treating bovine mastitis and preparation method thereof
  • Pharmaceutical composition for treating bovine mastitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] S1, under normal temperature and pressure, after mixing 6g oregano oil and 3g eugenol, stir evenly, as the oil phase;

[0027] S2. Add 33g Tween-80 as a surfactant to the oil phase, and stir evenly to obtain a mixed solution A;

[0028] S3, get 0.25g chlorhexidine acetate and add in 9g ethanol, stir to make it dissolve, then add it in the mixed solution A of gained and stir evenly;

[0029] S4. Slowly add 48.75g of distilled water into the above mixed solution, and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring until a nanoemulsion is formed. this invention.

[0030] After the present invention is diluted 5 times with distilled water, it can perfuse the udder of cows, effectively prevent and treat mastitis caused by various pathogenic bacteria, restore milk production, reduce economic losses, and improve breeding benefits of dairy cows.

Embodiment 2

[0032] S1. Under normal temperature and pressure, mix 12g oregano oil and 6g eugenol, stir evenly, and use it as the oil phase;

[0033] S2. Add 48g Tween-80 as a surfactant to the oil phase, and stir evenly to obtain a mixed solution A;

[0034] S3, get 0.5g chlorhexidine acetate and add in 16g ethanol, stir to make it dissolve, then add it in the mixed solution A of gained, stir evenly;

[0035] S4. Slowly add 17.5g of distilled water into the above mixture, and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring until a nanoemulsion is formed, which is the product. invention.

[0036] After diluting the present invention 10 times with distilled water, it can perfuse the udder of dairy cows, effectively prevent and treat mastitis caused by various pathogenic bacteria, restore milk production, reduce economic losses, and improve breeding benefits of d...

Embodiment 3

[0038] S1. Under normal temperature and pressure, mix 0.2g oregano oil and 0.05g eugenol, stir evenly, and use it as the oil phase;

[0039] S2. Add 0.9g Tween-80 as a surfactant to the oil phase, and stir evenly to obtain mixture A;

[0040] S3, get 0.05g chlorhexidine acetate and add in 0.3g ethanol, stir to make it dissolve, then add it in the mixed solution A of gained, stir evenly;

[0041] S4. Slowly add 98.5g of distilled water into the above mixture, and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring until a nanoemulsion is formed, and the product is obtained. invention.

[0042] The invention can directly perfuse the udders of cows suffering from recessive mastitis, can effectively prevent and treat mastitis caused by various pathogenic bacteria, restore milk production, reduce economic losses, and improve breeding benefits of dairy cows....

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Abstract

The invention discloses a pharmaceutical composition for treating bovine mastitis and a preparation method thereof. The composition is prepared from the following raw materials in percentages by weight: 0.2-12% of origanum oil, 0.05-6% of eugenol, 0.05-0.5% of chlorhexidine acetate, 0.9-48% of a surfactant, 0.3-16% of a cosurfactant and 17.5-98.5% of distilled water, and the total parentages by weight of the raw materials is 100%. The Chinese herbal medicine extracts, namely the origanum oil and the eugenol and a chemical drug chlorhexidine acetate are compounded to prepare a nano emulsion; the particle sizes are 1-100nm and the appearance is a transparent liquid; the pharmaceutical composition can be infinitely diluted, bovine mastitis can be treated through breast perfusion; and the pharmaceutical composition is free of resistance, free of a residue, small or free of toxic and side effect, convenient to use, safe and efficient.

Description

technical field [0001] The invention relates to the field of animal husbandry, in particular to a pharmaceutical composition for treating cow mastitis and a preparation method thereof. Background technique [0002] Cow mastitis is one of the three major diseases of dairy cows. Globally, mastitis in cows causes billions of dollars in economic losses every year, and it also affects milk production and the quality of its dairy products. For a long time, antibiotic drugs have been widely used to treat dairy cow mastitis. Although they are effective, the large-scale use of such drugs is likely to produce drug resistance and form antibiotic milk, causing potential harm to human health. [0003] Nanoemulsion is a thermodynamically stable, isotropic, transparent or translucent homogeneous dispersion formed spontaneously in a certain proportion by water, oil, surfactants and co-surfactants, etc., with a particle size of 1-100 nm. system. There are two types of nanoemulsions: oil-i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P15/14A61P31/04A61K31/085A61K31/155
CPCA61K31/085A61K31/155A61K36/53A61K2300/00
Inventor 张文娟王金虎吴旭锦尹宝英熊忙利
Owner XIANYANG VOCATIONAL TECHN COLLEGE
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