Compound kanamycin sulfate injection and preparation method thereof

A kanamycin sulfate and injection technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as unsatisfactory effects, reduce the probability of drug resistance, achieve fast curative effect, The effect of expanding the antibacterial range

Inactive Publication Date: 2017-10-24
山东中牧兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current kanamycin sulfate is not ideal for the treatment of swine paratyphoid, and the market is in urgent need of a good treatment for swine paratyphoid, which can not only enhance the resistance of pigs, but also treat mixed infections caused by various germs and viruses. and critical illness

Method used

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  • Compound kanamycin sulfate injection and preparation method thereof
  • Compound kanamycin sulfate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A compound kanamycin sulfate injection, each 1000L injection is made of the following raw materials: flunixin meglumine 30-110kg, kanamycin sulfate 30-110kg, trimethoprim 50-80kg, Edetate disodium 1-20kg, 95% ethanol 100-400L, glacial acetic acid 1-10L, and the rest is water for injection.

[0019] A kind of preparation method of above-mentioned compound kanamycin sulfate injection, it may further comprise the steps:

[0020] (1) Trimethoprim is dissolved in glacial acetic acid to obtain solution 1;

[0021] (2) Put disodium edetate into 95% ethanol, stir for 10-25 minutes until clear to obtain solution 2;

[0022] (3) Get 300L of water for injection, add kanamycin sulfate, flunixin meglumine and stir and dissolve successively to obtain solution 3;

[0023] (4) Solution 1, solution 2, and solution 3 prepared above were mixed, then water for injection was added to 1000L, stirred evenly, and kept for 15-20 minutes, and the compound kanamycin sulfate injection was obtain...

Embodiment 2

[0025] A compound kanamycin sulfate injection, each 1000L injection is made of the following raw materials: flunixin meglumine 30-110kg, kanamycin sulfate 30-110kg, trimethoprim 50-80kg, Edetate disodium 1-20kg, 95% ethanol 100-400L, glacial acetic acid 1-10L, and the rest is water for injection.

[0026] A kind of preparation method of above-mentioned compound kanamycin sulfate injection, it may further comprise the steps:

[0027] (1) Trimethoprim is dissolved in glacial acetic acid to obtain solution 1;

[0028] (2) Put disodium edetate into 95% ethanol, stir for 10-25 minutes until clear to obtain solution 2;

[0029] (3) Get 300L of water for injection, add kanamycin sulfate, flunixin meglumine and stir and dissolve successively to obtain solution 3;

[0030] (4) Solution 1, solution 2, and solution 3 prepared above were mixed, then water for injection was added to 1000L, stirred evenly, and kept for 15-20 minutes, and the compound kanamycin sulfate injection was obtain...

Embodiment 3

[0032] A compound kanamycin sulfate injection, each 1000L injection is made of the following raw materials: flunixin meglumine 30-110kg, kanamycin sulfate 30-110kg, trimethoprim 50-80kg, Edetate disodium 1-20kg, 95% ethanol 100-400L, glacial acetic acid 1-10L, and the rest is water for injection.

[0033] A kind of preparation method of above-mentioned compound kanamycin sulfate injection, it may further comprise the steps:

[0034] (1) Trimethoprim is dissolved in glacial acetic acid to obtain solution 1;

[0035] (2) Put disodium edetate into 95% ethanol, stir for 10-25 minutes until clear to obtain solution 2;

[0036] (3) Get 300L of water for injection, add kanamycin sulfate, flunixin meglumine and stir and dissolve successively to obtain solution 3;

[0037] (4) Solution 1, solution 2, and solution 3 prepared above were mixed, then water for injection was added to 1000L, stirred evenly, and kept for 15-20 minutes, and the compound kanamycin sulfate injection was obtain...

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Abstract

The invention discloses compound kanamycin sulfate injection and belongs to the technical field of veterinary drug preparation. Each 1000L of the compound kanamycin sulfate injection is prepared from the following raw materials of 30 to 110kg of flunixin meglumine, 30 to 110kg of kanamycin sulfate, 50 to 80kg of trimethyoprim, 1 to 20kg of edentate disodium, 100 to 400L of 95% ethanol, 1 to 10L of glacial acetic acid and the balance of water for injection. The compound kanamycin sulfate injection disclosed by the invention has wide antibacterial spectrum and wide antibacterial range, can comprehensively treat swine paratyphoid and certain complication, has high and quick curative effect, reduces drug fast rate of bacteria and improves the curative effect.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound kanamycin sulfate injection and a preparation method thereof. Background technique [0002] In recent years, with the large-scale and intensive development of animal husbandry and the increase of breeding density, various diseases, especially respiratory diseases of livestock and poultry, are increasing day by day. Antibacterial drugs are frequently used clinically, and bacteria are prone to drug resistance. This has greatly increased the breeding cost of livestock and poultry. Exploring a long-acting drug for treating respiratory diseases is one of the important ways to reduce drug residues, reduce feeding costs and improve economic benefits in animal husbandry production. [0003] Porcine paratyphoid fever is a common infectious disease of pigs. It poses a great threat to the pig industry. It is often the focus of prevention and treatment of piglet diarrhea in wint...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/505A61K31/198A61K31/44A61K9/08A61P31/04
CPCA61K31/44A61K9/08A61K31/198A61K31/505A61K31/7036A61K47/10A61K47/12A61K2300/00
Inventor 王统高
Owner 山东中牧兽药有限公司
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