Metal microneedle and preparation method thereof

Abstract

The invention discloses a metal microneedle and a preparation method thereof. The metal microneedle comprises a metal base, wherein a plurality of metal needle pillars are arranged on the metal base, and are perpendicular to the metal base; a metal needle tip is arranged at the end part of each metal needle pillar; and the metal base, each metal needle tip and each metal pillar are made of inert metal, so that the metal microneedle provided by the invention has sufficient hardness, can effectively pierce a skin cuticula, is sharp in the needle tips, can pierce a skin without causing pain, and is low in skin injury, fast to recover, and favorable for percutaneous absorption of macromolecules. The preparation method comprises the following steps of selecting a silicon substrate, manufacturing downward concave pyramid structures, manufacturing thick rubber electroplated layers on the downward concave pyramid structures, evaporating and plating metal conducting layers and electroplated layers on the thick rubber electroplated layers to obtain a metal microneedle graphics layer, and finally removing the silicon substrate to obtain the metal microneedle. By adopting the preparation method provided by the invention, the metal microneedle can be obtained.

Description

Technical field [0001] The invention belongs to the technical field of micro-nano electronics manufacturing, and relates to biomedical materials, in particular to a metal microneedle and a preparation method thereof. Background technique [0002] Microneedles generally refer to needle-like structures made by micro-processing technology, with a size of micrometers, a diameter of 30-80 micrometers, and a length of more than 100 micrometers. The material can be silicon, polymer, metal, etc. Microneedles have a wide range of applications in the biomedical field, such as biomedical measurement systems, drug delivery systems, and micro-sampling analysis systems. The microneedle is not only small in size, but also has characteristics that cannot be matched by conventional methods, such as fineness, painlessness, high efficiency and convenience. This greatly promotes the development of biomedicine and makes the instruments in this field more humane. [0003] The structure of human skin, ...

AI Technical Summary

Problems solved by technology

[0004] Although modern biomedical technology has produced extremely effective and mature drugs, the effective delivery of many drugs is limited by current delivery technologies

For example, the main problem of oral drugs is the degradation of the drug in the gastrointestinal tract and the excretion of the drug through the liver; another drug is injected intravenously, which is not easy to use in some non-medical places, and the drug effect is not easy to maintain and release, and there is pain

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