Compostion comprising siallyllactose for use in enhancing learning skills and memory function

A technology of sialyllactose and sialic acid, applied in the field of enhancing individual learning skills and memory function, can solve problems such as unclear internal mechanism

Pending Publication Date: 2017-12-01
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the underlying mechanisms explaining the relationship between breastfeeding and cognitive development remain unclear

Method used

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  • Compostion comprising siallyllactose for use in enhancing learning skills and memory function
  • Compostion comprising siallyllactose for use in enhancing learning skills and memory function
  • Compostion comprising siallyllactose for use in enhancing learning skills and memory function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0268] Example 1: Contains 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) nutritional composition

[0269] The nutritional composition comprising 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) is shown in Table 1 below. This composition is given by way of example only.

[0270] Table 1 :

[0271]

[0272]

Embodiment 2

[0273] Example 2: Effect of Dietary Supplementation with Sialic Acid on Learning Skills

[0274] The following study was carried out to investigate the effect of dietary sialic acid in both protein-bound and oligosaccharide-bound forms and the combination of sialic acid and lactoferrin on the learning ability of neonatal piglets.

[0275] animal model

[0276] Three-day-old full-term healthy male domestic piglets (Sus scrofa, Landrace × Large White cross) were purchased from a commercial piggery. The porcine model was chosen because the possibility of using pigs for pediatric brain research was recognized more than 40 years ago due to the similarity between pigs and humans in terms of global brain growth, gross anatomy, and neonatal brain growth patterns at birth sex. The pig digestive system has similar physiology and anatomy to a human infant, and pigs have nutritional requirements comparable to humans. These make piglets ideal for collaborative nutritional, metabolic...

Embodiment 3

[0302] Example 3: Effects of dietary supplementation of sialic acid on memory function

[0303] Following the assessment of learning skills as described in Example 2, the effect of dietary supplementation with sialic acid on short-term memory (STM) and long-term memory (LTM) of piglets was tested.

[0304] memory test

[0305] Two days after completion of each set of trials, the same task as described in Example 2 was performed as a "memory test". Piglets were assessed for 'short-term memory' (STM) and 'long-term memory' (LTM) based on the time interval between trials. Four trials were performed each morning and four trials in the afternoon. Each piglet was tested in two consecutive trials. Intervention intervals for changing visual cues and placing fresh milk between trials were 5 min (corresponding to 5 min short-term memory). During these 5 minutes, the piglets were located in the waiting area outside the testing area. After 40 minutes (corresponding to 40 minutes ...

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Abstract

This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional compositioncomprises 3'-Siallylactose (3'-SL) and 6'- Siallylactose (6'-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and / or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.

Description

technical field [0001] The present invention relates to a nutritional composition comprising 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) and to the use of said composition for enhancing learning skills and memory functions in an individual the use of. This enhancement is achieved in particular by increasing the concentration of sialic acid (Neu5Ac) in the brain of said individual and / or enhancing the neuroplasticity of the brain of said individual by the nutritional composition according to the invention. Background technique [0002] The early stages of infant neurodevelopment are critical for the establishment of neural structures and synaptic connections that influence the health of the brain's biochemical function later in life, including adulthood. This postnatal period of rapid neural growth is important for cell migration, neurite outgrowth, synaptic plasticity, and axon bundling. These processes therefore place very high demands on the intracellular pool ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125
CPCA23L33/125A23V2002/00A23V2200/322A23L33/40A23L33/10C07H3/04C07H5/04A61P25/28
Inventor 董志忠石羽杰王冰
Owner SOC DES PROD NESTLE SA
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