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Composition for relieving menopausal symptom or osteoporosis

A technology of osteoporosis and composition, applied in the direction of drug combination, application, food science, etc., can solve the problems of increasing breast cancer, increasing the proportion of uterine cancer and high blood pressure, etc., and achieve the effect of no toxic side effects and high applicability

Inactive Publication Date: 2017-12-05
LG HOUSEHOLD & HEALTH CARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, female hormone therapy, which is widely used in medicine, may increase the risk of breast cancer, etc., and may increase the rate of uterine cancer, thrombotic vascular disease, gallbladder disease, and high blood pressure when used for a long time

Method used

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  • Composition for relieving menopausal symptom or osteoporosis
  • Composition for relieving menopausal symptom or osteoporosis
  • Composition for relieving menopausal symptom or osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0119] Preparation Example 1. Preparation of Extracts for In Vitro Evaluation

[0120] As the extract used in the following examples, the ethanol extract prepared by OBM RAP CO., LTD was used, the raw material input process by mixing raw materials and 100% alcohol, the process of extraction at room temperature, the filtration process of removing impurities, Extracts were prepared in a concentration process to form a solid content of 85%, and used in experiments with cells in vitro.

preparation example 2

[0121] Preparation Example 2. Preparation of Soft Capsules for Clinical Evaluation of Perimenopause Comprehensive Scale

[0122] The production process of soft capsules for clinical evaluation is roughly divided into the production process of the main raw material (menopausal material) and the production process of soft capsules.

[0123] First, as the main raw material, 10 times the amount of purified water was added to a dry powder sample of kudzu root, and then extracted at 80° C. for 6 hours with an extraction device to prepare an extract. The extract was filtered with a filter paper having a diameter of 160 mm, and the filtered extract was concentrated under reduced pressure and freeze-dried to prepare a powdery extract. Extracts from orange shell were also prepared in the same way.

[0124] After that, the climacteric material as the main raw material was mixed with soybean oil, beeswax, soybean lecithin, and D-α-tocopheryl acetate (D-α-tocopheryl) as excipients, and th...

experiment example 1

[0127] Experimental Example 1. Measurement of Cell Viability of MCF-7 Cells

[0128] The cell viability (Cell Viability) of the extract on MCF-7 cell line which is a human estrogen receptor benign breast cancer cell line was measured. CCK-8 analysis using MCF-7 cells is an experimental method for confirming the effect of natural estrogen in the sample on women.

[0129] MCF-7 cells were cultured in a 96-well plate using DMEM medium supplemented with 10% FBS. After culturing for 24 hours, it was divided into a negative control group (no treatment group, control) and a positive control group (Estradiol treatment group, E2). After mixed treatment with orange shell extract, the cell viability (Cell Viability) was measured by CCK-8 after 72 hours. Every used in the medium The CCK-8 reagent was put into the culture medium, and the absorbance was measured at 450 nm after 1 hour. The result is in figure 1 shown in .

[0130] Such as figure 1 As shown, it was confirmed that e...

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Abstract

The present invention relates to the female menopausal disorder prevention and / or the osteoporosis improvement, and the effect that is quick as to the composition of the invention is in the female menopausal disorder prevention or the improvement. Therefore the effect can be used to the hormone replacement therapy (Hormone replacement therapy: HRT) used for the prevention or the improvement of the conventional climacteric symptom. Moreover, the side effect is safe in addition the cytotoxin does not have to the therapeutic agent about the conventional female menopausal disorder the composition of the invention is used as food. Therefore the therapeutic agent can be used in comparison with the therapeutic agent about the conventional female menopausal disorder.

Description

technical field [0001] The present invention relates to a composition for preventing, improving or treating female climacteric symptoms and / or osteoporosis comprising kudzu root mixed extract. Background technique [0002] Menopause refers to the interruption of menstruation in women after 50 years of failure of hereditary ovarian function after birth. This implies loss of fertility, and it is a physiological change that is not a pathological phenomenon. At present, the average life expectancy of Korean women is 81.2 years (2011: National Statistics Office). If the average age of menopause of Korean women stipulated by the Korean Association of Obstetricians and Gynecologists is set to 50 years old, women in She spends more than 1 / 3 of her life in the state of estrogen depletion (Kim Sung-chul, Institute of Pharmaceutical Information). [0003] The uneven and decreased secretion of estrogen due to menopause causes changes throughout the body including the vascular system, ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P15/12A61K8/9789A23L33/105
CPCA23L33/105A61K8/97A61K36/488A61K36/752A23V2002/00A61K2300/00A23V2200/30A23V2250/21A61Q19/00A61K8/9789A23V2200/306A23V2200/302
Inventor 李耎姃赵浩成李媛卿宋舜蘭李相和
Owner LG HOUSEHOLD & HEALTH CARE LTD
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