Compound enteric-coated orally disintegrating table and preparation method thereof

Abstract

The invention provides a compound enteric-coated orally disintegrating table and a preparation method thereof, wherein the compound enteric-coated orally disintegrating table is prepared from the following components in parts by weight: 20-30 parts of sodium mycophenolate, 0.3-3 parts of tacrolimus, 30-40 parts of core pellet, 2-10 parts of stabilizer, 2-10 parts of separant, 2-10 parts of entericcoating material, 10-20 parts of filling agent, 10-30 parts of disintegrating agent, and 0.1-3 parts of lubricating agent. The compound enteric-coated orally disintegrating table disclosed by the invention has the advantages of being small in particle size, quick in absorption, high in bioavailability, good in taste and easy to swallow, improves the medicine taking compliance of the patient, andis beneficial for treatment of diseases; meanwhile, under the synergistic effect of sodium mycophenolate and tacrolimus, tacrolimus and sodium mycophenolate can be prepared into a compound preparationwhile reducing the use dosage of tacrolimus so as to achieve a synergistic effect of decrement and equivalence; and the compound enteric-coated orally disintegrating table has a more remarkable advantage in inhibiting effect than the medicine of any formula which generates various rejection reactions in postoperation of renal transplantation patients, and remarkably reduces various side effects.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound enteric-coated orally disintegrating tablet and a preparation method thereof. Background technique [0002] About 70,000 people around the world receive organ transplants every year, most of which are kidney transplants. In China, more than 5,000 patients receive kidney transplants every year. How to improve the long-term survival rate of transplanted organs has always been a major problem in the medical field. The human immune system has the ability to recognize "self" and "non-self". Usually, it only produces an immune response to foreign antigens, but immune tolerance to self-antigens. Therefore, the immune system's rejection of allografted organs hinders the success of organ transplantation. Although the immunosuppressive regimen consisting of macrocyclic lactone antibiotic structure immunosuppressants, calcineurinase inhibitors, and adrenal c...

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Problems solved by technology

[0006] The purpose of the present invention is to disclose a compound enteric-coated orally disintegrating tablet, which is used to solve the inhibitory effect of the compound enteric-coated orally disintegrating tablet using tacrolimus alone on various types of rejection reactions in kidney transplant patients in the prior art. And reduce the dosage of tacrolimus and its toxic and side effects on the human body, reduce long-term mortality; at the same time, the present invention also proposes a preparation method of compound enteric-coated orally disintegrating tablets, in order to accelerate absorption and improve drug The purpose of the utilization of traditional anti-rejection drugs, and to solve the technical problems of organ transplantation patients with dysphagia

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