Method of simultaneously detecting concentrations of paracetamol and 4-aminophenol

A technology of acetaminophen and aminophenol, which is applied in the field of electroanalytical chemistry, can solve problems such as expensive, time-consuming, and tedious, and achieve the effects of simple operation, fast analysis, and high sensitivity

Active Publication Date: 2018-02-13
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods are expe...

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  • Method of simultaneously detecting concentrations of paracetamol and 4-aminophenol
  • Method of simultaneously detecting concentrations of paracetamol and 4-aminophenol
  • Method of simultaneously detecting concentrations of paracetamol and 4-aminophenol

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Embodiment Construction

[0017] (1) Preparation of 2,6-diaminopyridine-o-carboxybenzaldehyde bis-Schiff base cobalt complex modified glassy carbon electrode

[0018] a. A glassy carbon electrode with a ø of 2 mm was polished to a mirror surface on suede with nano-alumina powders of 0.03 μm and 0.1 μm, ultrasonicated in distilled water for 20 min, washed with distilled water, and placed in an oven at 50 °C Dry for 5 min to obtain a pretreated bare glassy carbon electrode.

[0019] b. Dissolve 2,6-diaminopyridine-o-carboxybenzaldehyde bis-Schiff base cobalt complex in dimethyl sulfoxide (DMSO) solvent, and configure to 0.01 mol L -1 solution, and tetrabutylammonium perchlorate (TBAP) was added as a supporting electrolyte to obtain an electrolyte.

[0020] c. Using cyclic voltammetry, using a three-electrode system, using the bare glassy carbon electrode pretreated in step (1) step a as the working electrode, the Ag / AgCl electrode as the reference electrode, and the platinum wire electrode as the auxili...

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Abstract

The invention discloses a method of simultaneously detecting concentrations of paracetamol and 4-aminophenol. The method comprises the following steps: preparing 2,6-diaminopyridine o-carboxybenzaldehyde bis-schiff base cobalt complex modified glassy carbon electrode by an electro-deposition process; simultaneously measuring the oxidation peak current values of paracetamol and 4-aminophenol withina concentration range from 5 to 30mumol.L<-1> by a differential pulse process, wherein the oxidation peak current is in a good linear relationship with the concentration thereof, and the detection limits are 1.64*10<-5>mol.L<-1> and 2.39*10<-5>mol.L<-1> respectively. The method disclosed by the invention can be used for simultaneously detecting the concentrations of paracetamol and 4-aminophenol,and has the advantages of easiness in operation, fast analysis, high sensitivity, stable system and high reproducibility.

Description

technical field [0001] The invention belongs to the field of electroanalytical chemistry, in particular to a method for simultaneously detecting the concentrations of acetaminophen and 4-aminophenol by using a modified glassy carbon electrode. Background technique [0002] Drugs can treat diseases, but they can also have adverse reactions to humans. Through drug analysis, the content of active ingredients and bad ingredients can be obtained, thereby improving the effectiveness and safety of medication, and reducing the cost and risk of drug treatment. Paracetamol is a world-renowned drug, also known as acetaminophen. 4-Aminophenol (4-AP), has nephrotoxic and teratogenic effects. On the one hand, 4-aminophenol is the raw material for the synthesis of acetaminophen; on the other hand, acetaminophen may degrade under light to obtain 4-aminophenol (4-AP). This may lead to the presence of 4-aminophenol in large quantities in the drug, so simultaneous determination of 4-aminoph...

Claims

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Application Information

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IPC IPC(8): G01N27/26G01N27/30G01N27/36
CPCG01N27/26G01N27/30G01N27/36
Inventor 刘峥李海莹韩佳星廖秋梅
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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