A kind of scar removing composition and preparation method thereof

A composition and technology for removing scars, which can be used in drug combinations, effective ingredients of hydroxyl compounds, pharmaceutical formulations, etc., and can solve problems such as not being able to meet the needs of the market

Active Publication Date: 2021-04-27
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although various products developed for scar removal have emerged in an endless stream in recent years, there are still relatively few products with significant curative effect, high safety, convenient use and industrial production, which cannot meet the needs of the market.

Method used

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  • A kind of scar removing composition and preparation method thereof
  • A kind of scar removing composition and preparation method thereof
  • A kind of scar removing composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 composite bioactive factor nano liposome

[0027]

[0028]

[0029] The preparation of the complex bioactive factor nanoliposome described in group A of the present invention comprises the following steps:

[0030] (1) Weigh 0.2g of phosphatidylcholine, 0.08g of cholesterol, and 0.04g of distearoylphosphatidylethanolamine, mix them, dissolve in 50mL of ethanol, and sonicate for 5min;

[0031] (2) Rotate evaporation at 28°C and 0.1MPa to remove ethanol, let it stand for 30min, add 100mL pH of 7.4 phosphate buffer solution containing 0.5% (m / v) complex biologically active factors, and place in a water bath at 35°C Medium shaking hydration reaction for about 1 hour to obtain liposome suspension;

[0032] (3) Use a syringe filter to adjust the particle size of the liposome suspension to 150nm to obtain nanoliposomes of complex bioactive factors.

[0033] For the preparation of complex biologically active factor nanoliposomes in groups...

Embodiment 2-4 and comparative example 1-4

[0034] Preparation of Example 2-4 and Comparative Example 1-4 Composition for Dispelling Scars

[0035] The composition of embodiment 2-4 of the present invention and comparative example 1-4 scar removal composition is shown in the table below:

[0036]

[0037]

Embodiment 2

[0038] The preparation of embodiment 2 scar removal composition:

[0039] Dissolve polyvinylpyrrolidone K30 in distilled water, add glycerin and 1,2-propanediol, and stir evenly to make a matrix; add lipoic acid, hexamerpeptide, minetal peptide, plumbagin, and inositol in sequence, stir well, and finally Add composite bioactive factor nanoliposome and imidazolidinyl urea, vortex for 4min, and obtain.

[0040] For the preparation of the scar-removing compositions of Examples 3 and 4 and Comparative Examples 1-4, refer to the above-mentioned method.

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Abstract

The invention relates to a scar-removing composition, which comprises the following ingredients in mass percentage: 2-8% of hexamereptide, 2-8% of mineral peptide, 1-4% of lipoic acid, 0.05-1% of plumbagin, muscle 1-4% of alcohol, 2-6% of complex bioactive factor nano liposome, 0.01-1.0% (m / v) of preservatives and 70-80% of auxiliary materials. The scar removal composition can significantly enhance the activity of matrix metalloproteinases, promote its degradation of accumulated type I collagen, significantly reduce the expression of fibronectin, reduce the density of fibroblasts, slow down the formation of scars, and reduce scar hyperplasia index, showing better scar removal effect; meanwhile, clinical data show that the scar removal composition also has better curative effect on volunteer patients with hypertrophic scars, with a cure rate of 96.7%.

Description

technical field [0001] The invention relates to the technical field of scar repair, in particular to a scar removing composition and a preparation method thereof. Background technique [0002] Scar is a hyperplastic lesion caused by trauma. Its tissue is formed by collagen fibers and matrix, fibroblasts and local mucopolysaccharide deposition. The formation process includes different stages such as inflammation, cell migration / proliferation and deposition of extracellular matrix. The clinical manifestations are damaged skin shape and different degrees of dysfunction. According to the different causes and symptoms of scar formation, it can be divided into superficial scars, hypertrophic scars, atrophic scars, contracture scars, depressed scars, painful scars, and keloids. At present, the mechanism of scar formation is not yet fully understood. It is generally believed that the massive proliferation and apoptosis of fibroblasts in wound repair, the unbalanced synthesis and de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/19A61K9/127A61P17/02A61K38/08A61K38/18A61K31/385A61K31/122A61K31/047
CPCA61K9/127A61K31/047A61K31/122A61K31/385A61K38/08A61K38/18A61K38/193A61K2300/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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