Application of 450-490 nm LED-blue-light combined with arsenic trioxide in osteosarcoma treatment

A technology of osteosarcoma and osteosarcoma cells, applied in the medical field, can solve problems such as organ system lesions, achieve the effects of reducing side effects, significant effects, and reducing physical and mental damage
CN107737409AInactive Publication Date: 2018-02-27HARBIN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HARBIN MEDICAL UNIVERSITY
Publication Date
2018-02-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of 450-490 nm LED-blue-light combined with arsenic trioxide in osteosarcoma treatment. Trypan-blue dyeing, cell counting and the EdU dyeing method are adopted to detect the influence of the 450-490 nm LED-blue-light combined with the arsenic trioxide on osteosarcoma cell growth and proliferation, scratch tests and Transwell tests are applied to detecting the influence on cell migration and invasion capabilities, and gamma-H2AX immunofluorescent staining is applied to detecting the influence on cell nucleus damage. Test results show that through combination of the 450-490 nm LED-blue-light and As2O3, curative effects of independently used small-dosage As2O3 can be improved, the toxicity is reduced, the growth, proliferation, migration and invasion of osteosarcoma cells can be effectively inhibited, the cell nucleus damage is induced, and then the purposes of relieving and treating osteosarcoma are achieved. The clinical application of the 450-490 nm LED-blue-light combined with arsenic trioxide is simple and low in medical treatment cost, pain of treated patients is reduced at the same time, and a new technological means is provided for the osteosarcoma treatment.
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Description

technical field

[0001] The invention relates to 450-490nm LED-blue light combined with arsenic trioxide (Arsenic trioxide, As 2 o 3 ) in the treatment of osteosarcoma. The invention belongs to the field of medical technology. Background technique

[0002] Osteosarcoma is a primary malignant bone tissue tumor that occurs frequently in children and adolescents. It has strong invasive ability, rapid disease progression, and extremely high fatality rate. At present, the clinical treatment methods for patients with osteosarcoma mainly include surgery, chemotherapy, radiotherapy, interventional therapy and other comprehensive treatment methods, but surgery will cause the risk of amputation, patients' resistance to radiotherapy and chemotherapy drugs and the prognosis of osteosarcoma The extremely poor effect is still a huge problem in the treatment of osteosarcoma and the improvement of the living standards of osteosarcoma patients. Since various treatment methods bring irreve...

Claims

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