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Omarigliptin tablet composition

A technology for aulogliptin tablets and compositions is applied in the field of pharmacy and can solve the problems of difficulty in preparation, increase of related substances, splits, etc., and achieves the effects of satisfying dissolution requirements, simple process, and solving the problem of hygroscopicity

Inactive Publication Date: 2018-03-16
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ologliptin is insoluble in water, which brings difficulty to the preparation of the preparation; the test also found that the relevant substances of the alogliptin tablet increased significantly during the storage process, and cracks occurred

Method used

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  • Omarigliptin tablet composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, 12.5g of alogliptin crossed 100 mesh sieves, 12g of chitosan with a molecular weight of 18,000-20,000, 16g of calcium hydrogen phosphate, 30g of corn starch, 20g of microcrystalline cellulose, 20g of lactose, and cross-linked carboxymethyl Sodium cellulose 8g, sodium lauryl sulfate 1.2g, magnesium stearate 0.8g, prepare 1000 tablets by the preparation method described in the technical scheme.

Embodiment 2

[0022] Embodiment 2, 25 g of alogliptin crossed 100 mesh sieves, 20 g of chitosan with a molecular weight of 18,000 to 20,000, 32 g of calcium hydrogen phosphate, 16 g of corn starch, 36 g of microcrystalline cellulose, 40 g of lactose, and cross-linked carboxymethyl Sodium cellulose 15g, sodium lauryl sulfate 1.6g, magnesium stearate 1.5g, prepare 1000 tablets by the preparation method described in the technical scheme.

Embodiment 3

[0023] Embodiment 3, 15g of alogliptin crossed 100 mesh sieves, 15g of chitosan with a molecular weight of 18,000-20,000, 24g of calcium hydrogen phosphate, 24g of corn starch, 28g of microcrystalline cellulose, 30g of lactose, cross-linked carboxymethyl Sodium cellulose 11g, sodium lauryl sulfate 1.4g, magnesium stearate 1.2g, prepare 1000 tablets by the preparation method described in the technical scheme.

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Abstract

The invention relates to an alogliptin composition and belongs to the technical field of pharmacy. The technical scheme of the present invention is: in the alogliptin composition of unit dosage, contain the alogliptin 12.5-25 mg that passes 100 mesh sieves, the chitosan 12-20mg that molecular weight is 1.8-20,000, calcium hydrogen phosphate 16‑32mg, corn starch 16‑30mg, microcrystalline cellulose 20‑36mg, lactose 20‑40mg, croscarmellose sodium 8‑15mg, sodium lauryl sulfate 1.2‑1.6mg, magnesium stearate 0.8-1.5 mg. The invention provides an alogliptin tablet composition with stable quality.

Description

technical field [0001] The invention relates to an alogliptin composition and belongs to the technical field of pharmacy. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. It seriously affects the quality of life of patients. [0003] The International Diabetes Federation estimates that the number of people with diabetes worldwide will rise to 592 million by 2035. About 80% of people with diabetes live in low- and middle-income countries. In China, the prevalence of diabetes is increasing rapidly. Comparing the National Diabetes Survey between 1981 and 2010, the prevalence of diabetes in my country has increased by 17 times. [0004] According to the survey, ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/38A61K47/26A61K47/20A61K31/4162A61P3/10
CPCA61K9/2059A61K9/2013A61K9/2018A61K9/2054A61K31/4162
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH
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