A kind of lilac extract and its preparation method and application

A technology of lilac and extract, applied in the direction of medical formula, drug combination, plant raw materials, etc.

Active Publication Date: 2021-07-06
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are few literature reports on the chemical constituents contained in the trunk, branches and roots of lilac and their medicinal effects.

Method used

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  • A kind of lilac extract and its preparation method and application

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Effect test

Embodiment 1

[0052] The preparation method of the lilac extract of the present embodiment comprises the following steps: 1 kg of lilac branches containing heartwood is ultrasonically extracted 3 times with 8 kg of petroleum ether, each extraction is 0.5 hour, the combined extracts are filtered, concentrated under reduced pressure, Vacuum drying, that is.

[0053] Further separation and purification, structural identification and HPLC content determination showed that it contained the following components: 0.23% of 3,4-bis-(3-methoxy-4-hydroxybenzyl)tetrahydrofuran, 0.34% of secoisolaricine resinol , 2,3-bis-(3-methoxy-4-hydroxybenzyl)-3,4-epoxybutanol 0.17%, 2-hydroxy-3,4-bis-(3-methoxy-4 -Hydroxybenzyl)tetrahydrofuran 0.18%, 2-(3,4-methylenedioxybenzyl)-3-(3-methoxy-4-hydroxybenzyl)-1,4-butanediol 0.16% , Piper cubeba element 0.15%.

Embodiment 2

[0055] The preparation method of the lilac extract of this embodiment comprises the following steps: 1 kg of the dried trunk of lilac is heated and refluxed with 10 kg of petroleum ether to extract 3 times, each extraction is 1 hour, the extracts are combined, filtered, concentrated under reduced pressure, and frozen Dry and serve.

[0056] Further separation and purification, structural identification and HPLC content determination showed that it contained the following components: 0.28% of 3,4-bis-(3-methoxy-4-hydroxybenzyl)tetrahydrofuran, 0.39% of secoisolaricresinol , 2,3-bis-(3-methoxy-4-hydroxybenzyl)-3,4-epoxybutanol 0.20%, 2-hydroxy-3,4-bis-(3-methoxy-4 -Hydroxybenzyl)tetrahydrofuran 0.20%, 2-(3,4-methylenedioxybenzyl)-3-(3-methoxy-4-hydroxybenzyl)-1,4-butanediol 0.19% , Piper cubeba element 0.17%.

Embodiment 3

[0058] The preparation method of the lilac extract of the present embodiment comprises the following steps: 1kg of the dried root of lilac is heated and refluxed with 12kg of petroleum ether to extract 3 times, each extraction is 1.5 hours, the extracts are combined, filtered, concentrated under reduced pressure, and sprayed Dry and serve.

[0059] Further separation and purification, structural identification and HPLC content determination showed that it contained the following components: 0.30% 3,4-bis-(3-methoxy-4-hydroxybenzyl)tetrahydrofuran, 0.42% secoisolaricine resinol , 2,3-bis-(3-methoxy-4-hydroxybenzyl)-3,4-epoxybutanol 0.22%, 2-hydroxy-3,4-bis-(3-methoxy-4 -Hydroxybenzyl)tetrahydrofuran 0.24%, 2-(3,4-methylenedioxybenzyl)-3-(3-methoxy-4-hydroxybenzyl)-1,4-butanediol 0.22% , Piper cubeba element 0.19%.

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Abstract

The invention belongs to the extraction field of natural medicines, and in particular relates to a lilac extract, a preparation method and application thereof. The lilac extract contains the following components: 3,4-bis-(3-methoxy-4-hydroxybenzyl)tetrahydrofuran, secoisolariciresinol, 2,3-bis-(3-methoxy ‑4‑hydroxybenzyl)‑3,4‑epoxybutanol, 2‑hydroxy‑3,4‑di‑(3‑methoxy‑4‑hydroxybenzyl) tetrahydrofuran, 2‑(3,4‑time Methylenedioxybenzyl)‑3‑(3‑methoxy‑4‑hydroxybenzyl)‑1,4‑butanediol, pipecubabin; experiments showed that the lilac extract could significantly prolong the Sleep time and significantly reduce the number of autonomous activities in mice, and has a significant sedative and tranquilizing effect.

Description

technical field [0001] The invention belongs to the extraction field of natural medicines, and in particular relates to a lilac extract, a preparation method and application thereof. Background technique [0002] Lilac (Syringa oblata Lindl.) is a plant of the genus Syringa in the family Oleaceae. There are about 19 species of this plant, and there are 15 species in my country. Lilac has a wide geographical distribution, mostly in Liaoning, Beijing, Hebei, Shaanxi, Henan and other places. According to the records in "Compendium of Xinhua Materia Medica" and "Changbai Mountain Botanical Medicine", lilac has the effect of treating acute jaundice hepatitis, diarrhea, hepatitis, etc.; in addition, the leaves of lilac have long been used by folks as antibacterial and anti-inflammatory, clearing liver and gallbladder medicine. [0003] At present, dozens of chemical components have been isolated from the bark, leaves and flowers of Syringa plants; from the analysis of chemical s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/61A61P25/20
CPCA61K36/61A61K2236/35
Inventor 张樱山张国霞路杰陈丽娟
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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