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External liquid medicine for treating leuconychia and preparation method thereof

A technology of onychomycosis and liquid medicine, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve the problems of strong drug irritation, temporary cure, high recurrence rate, etc., and achieve strong permeability and curative effect High and low cost effect

Inactive Publication Date: 2018-03-23
陈祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the drug is highly irritating and has unbearable pain. It needs long-term application of the drug to work. It treats the symptoms but not the root cause, and the recurrence rate is high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]The external medicinal liquid for treating onychomycosis of the present embodiment is composed of medicinal liquid A and medicinal liquid B in a weight ratio of 1:2, wherein, said medicinal liquid A is made of the following raw materials: 40 kg of salicylic acid, glacial acetic acid 220kg and 700kg of ethanol solution with a mass concentration of 70%. The medicinal solution B is made of the following raw materials: 250kg of ethanol extract of Coptidis Rhizoma, 120kg of ethanol extract of Phellodendron Phellodendri, and 80kg of ethanol extract of Scutellaria baicalensis. The solution is prepared by the following method: crush the dried Coptis rhizome to a particle size of 100 mesh, soak it in an ethanol solution with a mass concentration of 70%, extract it at 45°C for 26h, centrifuge it at 1500rpm / min for 10min, and place it at a temperature of 60°C, Concentrate under reduced pressure at a pressure of 0.06 MPa, and then use an ethanol solution with a mass concentration of ...

Embodiment 2

[0048] The external medicinal liquid for treating onychomycosis of the present embodiment is composed of medicinal liquid A and medicinal liquid B in a weight ratio of 1:3, wherein said medicinal liquid A is made of the following raw materials: 50 kg of salicylic acid, glacial acetic acid 200kg and 750kg of ethanol solution with a mass concentration of 70%. The medicinal solution B is made of the following raw materials: 300kg of ethanol extract of Coptidis Rhizoma, 100kg of ethanol extract of Phellodendron Phellodendri, and 100kg of ethanol extract of Scutellaria baicalensis. The solution is prepared by the following method: crush the dried Coptis rhizome to a particle size of 100 mesh, soak it in an ethanol solution with a mass concentration of 70%, extract it at 50°C for 24h, centrifuge it at 1500rpm / min for 10min, and place it at a temperature of 70°C, Concentrate under reduced pressure at a pressure of 0.07 MPa, and then use an ethanol solution with a mass concentration of...

Embodiment 3

[0059] The external medicinal liquid for the treatment of onychomycosis of the present embodiment is composed of medicinal liquid A and medicinal liquid B in a weight ratio of 1:4, wherein said medicinal liquid A is made of the following raw materials: 60 kg of salicylic acid, glacial acetic acid 180kg and 800kg of ethanol solution with a mass concentration of 70%. The medicinal solution B is made of the following raw materials: 350kg of ethanol extract of Coptidis Rhizoma, 80kg of ethanol extract of Phellodendron Phellodendri, and 120kg of ethanol extract of Scutellaria baicalensis. The solution is prepared by the following method: crush the dried Coptis rhizome to a particle size of 100 mesh, soak it in an ethanol solution with a mass concentration of 70%, extract it at 55°C for 22h, centrifuge it at 1500rpm / min for 10min, and place it at a temperature of 80°C, Concentrate under reduced pressure at a pressure of 0.06 MPa, and then use an ethanol solution with a mass concentra...

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PUM

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Abstract

The invention discloses external liquid medicine for treating leuconychia and a preparation method thereof and belongs to the technical field of treatment of the leuconychia. The external liquid medicine is prepared from a liquid medicine A and a liquid medicine B according to the weight ratio of 1:(2-4), wherein the liquid medicine A is prepared from the following raw materials in parts by weight: 40-60 parts of salicylic acid, 180-220 parts of glacial acetic acid and 700-800 parts of ethanol solution with the mass concentration of 70%; the liquid medicine B is prepared from the following rawmaterials in parts by weight: 250-350 parts of rhizoma coptis-chinensis ethanol extracting solution, 80-120 parts of cortex-phellodendri ethanol extracting solution and 80-120 parts of radix scutellariae-baicalensis ethanol extracting solution. The invention also discloses a preparation method of the external liquid medicine for treating the leuconychia. The external liquid medicine for treatingthe leuconychia disclosed by the invention has the beneficial effects of capability of effectively treating the leuconychia, short treatment time, high curative effect, no side effect, convenience inuse, low cost, thorough eradication and no relapse.

Description

technical field [0001] The invention relates to an external medicinal solution for treating onychomycosis and a preparation method thereof, belonging to the technical field of onychomycosis treatment. Background technique [0002] Onychomycosis (toe) nail, also known as onychomycosis medically, is a disease caused by fungal invasion and infection of finger (toe) nail. The clinical manifestations are deformed, thickened, uneven, rough, dull or discolored nails, and incomplete nails. Onychomycosis has a high incidence rate and strong infectivity. Onychomycosis not only affects the appearance of hands and feet, but also can cause tinea manuum, tinea pedis, tinea corporis and other fungal infectious diseases. [0003] In the prior art, the medicine for treating onychomycosis includes oral medicine, injection medicine and external medicine. Among them, oral medicines and injection medicines, such as terbinafine tablets, itraconazole, and fluconazole, are mostly imported from ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P17/00A61P31/10A61K31/60A61K31/19A61K31/045
CPCA61K9/0014A61K31/045A61K31/19A61K31/60A61K36/539A61K36/718A61K36/756A61K2236/333A61K2236/51A61K2236/53A61K2300/00
Inventor 陈盛益陈祥
Owner 陈祥
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