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Hemostatic and anti-infection pharmaceutical composition

A composition and anti-infection technology, which is applied in the direction of drug combination, anti-infection drugs, anti-bacterial drugs, etc., can solve the problems of hemostasis and anti-infection effects, etc., and achieve good quality control, hemostatic antibacterial effect, and less drug smell Effect

Active Publication Date: 2018-03-23
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the hemostatic and anti-infective effects of tobacco leaves and baiji are not very satisfactory when used alone.

Method used

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  • Hemostatic and anti-infection pharmaceutical composition
  • Hemostatic and anti-infection pharmaceutical composition
  • Hemostatic and anti-infection pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0139] Example 1 (powder)

[0140] 1. Prescription: Tobacco 7500g, white and 2500g.

[0141] 2. Preparation method:

[0142] (1) Grind the tobacco, add 12 times the amount of methanol to reflux and extract 3 times, each time for 1.2h, filter, combine the filtrate, concentrate until there is no alcohol smell, add extractant for extraction, concentrate to extract, dry, grind, and obtain tobacco extract The extractant described therein is made by the following method: get ethyl acetate and add HCl to pH value 2.5;

[0143] (2) Take baijiu and grind it, add 4.5 times the amount of ethanol with a volume concentration of 90% to soak for 4.5 hours, drain, add 15 times the amount of distilled water, extract twice in a water bath at 90°C, each time for 1.5 hours, combine the filtrates, and centrifuge , concentrate, add ethanol for precipitation, let stand overnight, filter, collect the filter residue, wash with ethanol, dry, and obtain white and extract;

[0144] (3) Grind the tobac...

example 2

[0145] Example 2 (ointment)

[0146] 1. Prescription: tobacco 6500g, white and 3500g.

[0147] 2. Preparation method:

[0148] (1) Take tobacco and grind it, add 15 times the amount of methanol to reflux and extract 3 times, each time for 1.0h, filter, combine the filtrate, concentrate until there is no alcohol smell, add extractant for extraction, concentrate to extract, dry, grind, and obtain tobacco extract The extractant described therein is made by the following method: get ethyl acetate and add HCl to a pH value of 2;

[0149] (2) Take baijiu and grind it, add 6 times the amount of ethanol with a volume concentration of 80% to soak for 6 hours, drain, add 15 times the amount of distilled water, extract twice in a water bath at 90 ° C, each time for 1.5 hours, combine the filtrates, centrifuge, Concentrate, add ethanol to precipitate, stand overnight, filter, collect the filter residue, wash with ethanol, dry, and obtain white and extract;

[0150] (3) Take the tobacco...

example 3

[0151] Example 3 (Gel)

[0152] 1. Prescription: tobacco 8500g, white and 1500g.

[0153] 2. Preparation method:

[0154] (1) Grind the tobacco, add 10 times the amount of methanol to reflux and extract 3 times, each time for 1.5h, filter, combine the filtrate, concentrate until there is no alcohol smell, add extractant for extraction, concentrate to extract, dry, grind, and obtain tobacco extract matter; wherein the extractant is made by the following method: get ethyl acetate and add HCl to a pH value of 3;

[0155] (2) Take baijiu and grind it, add 3 times the amount of ethanol with a volume concentration of 95% to soak for 3 hours, drain, add 15 times the amount of distilled water, extract twice in a water bath at 90°C, each time for 1.5 hours, combine the filtrates, centrifuge, Concentrate, add ethanol to precipitate, stand overnight, filter, collect the filter residue, wash with ethanol, dry, and obtain white and extract;

[0156] (3) Take the tobacco extract prepared...

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Abstract

The invention relates to hemostatic and anti-infection pharmaceutical composition. The pharmaceutical composition comprises an effective component and medically acceptable auxiliaries, and is characterized in that the effective component is prepared from raw materials in percentage by weight as follows: 65%-85% of tobacco and 15%-35% of rhizoma bletillae. The pharmaceutical composition not only has remarkable hemostatic and anti-infection effects, but also contains fewer drug types and is stable in quality.

Description

technical field [0001] The present invention relates to preparations for medical use, in particular to pharmaceutical preparations containing undetermined structures from plants. Background technique [0002] Hemostasis is one of the cores of basic surgical techniques. Surgical operations on any part of the human body almost without exception involve bleeding and hemostasis. Hemostasis technology has developed from simple instrumental hemostasis measures in the past to a complex technical system under modern surgical conditions. . The application of hemostatic materials has become an important part of this process. Commonly used clinical hemostatic materials, such as hemostatic gauze, hemostatic fiber, hemostatic bandage, etc., have certain limitations in actual use, such as longer hemostasis time, easy to adhere to the wound, difficult to change dressings, and unable to treat wound infection and suppuration Wait. Modern trauma research mainly focuses on hemostatic materi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P7/04A61P31/00A61P31/04
CPCA61K36/81A61K36/898A61K2236/333A61K2236/35A61K2236/39A61K2236/55A61K2300/00
Inventor 郭培国李钟李玲陈菊英林鼎光夏岩石李荣华
Owner GUANGZHOU UNIVERSITY
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