The invention discloses a
drug delivery
carrier material, a
drug delivery
coating and a preparation method thereof, and belongs to the technical field of
biological materials. The preparation method of the
drug delivery
coating comprises the following steps: reacting polypeptide containing hydrophobic
amino acid with acidic
protein in a
solution system in which the pH value is 3-7, the temperature is 20-50 DEG C and an
oxidizing agent exists, and mixing the prepared
coating with a drug solution to realize drug filling, and then mixing with a
phosphate solution to induce the micro-nano pore structure in the coating to be closed. The isoelectric points of the polypeptide and the acidic
protein are both less than 7, and the difference value of the isoelectric points is less than or equal to 2.5; the acidic
protein is negatively charged under the condition that the pH is greater than or equal to 7. According to the method, the contradiction that
high loading and low burst release of an existing carrier are difficult to achieve at the same time is effectively solved, the coating is mild in drug loading condition, effective loading and activity retention of various active biomolecules can be achieved, the coating can also adapt to various drug types through
modular design, and a brand new mode is provided for constructing a next-generation intelligent
drug delivery system.