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Two-drug type local injection solution for submucosal injection

A local injection, mucosal technology, used in liquid delivery, aerosol delivery, emulsion delivery, etc., can solve the problem of not developing a local injection solution, etc.

Pending Publication Date: 2020-06-05
KYOTO PREFECTURAL PUBLIC UNIV CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at this stage, no excellent local injection solution has been developed that can replace HA

Method used

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  • Two-drug type local injection solution for submucosal injection
  • Two-drug type local injection solution for submucosal injection
  • Two-drug type local injection solution for submucosal injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0067] The present invention will be described in detail below in conjunction with examples and comparative examples.

[0068] In the examples, the following starting materials were used.

[0069] Sodium Alginate:

[0070] Product name Sodium alginate produced by Nacalai Tesque Co., Ltd.

[0071] Gellan Gum:

[0072] Product name KELCOGEL (CG-LA) produced by Sanjing Co., Ltd.

[0073] Carrageenan:

[0074] Product name GENUVISCO produced by Sanjing Co., Ltd. (CF02)

[0075] Sodium hyaluronate:

[0076] Product name MucoUp produced by Seikagaku Industry Co., Ltd.

preparation example 1

[0078] The following polysaccharide aqueous solutions and aqueous salt solutions were prepared as local injection solutions.

[0079] -Polysaccharide aqueous solution:

[0080] An aqueous solution of gellan gum (G-LA, 0.4%), hyaluronic acid (HA, 0.4%), sodium alginate (SA, 0.4%) or carrageenan (Agar, 1.0%) was prepared according to conventional methods.

[0081] -Aqueous salt solution:

[0082] Prepare 0.9% NaCl aqueous solution or 2.0% CaCl according to conventional methods 2 Aqueous solution.

[0083] These aqueous polysaccharide solutions and aqueous salt solutions were subjected to the following tests.

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Abstract

The present invention provides a two-drug type local injection solution for submucosal injection. The two-drug type local injection solution comprises (i) an aqueous polysaccharide solution containingat least one selected from the group consisting of sodium alginate, carrageenan, and gellan gum; and (ii) a saline solution containing at least one cation selected from the group consisting of sodiumions and calcium ions, wherein when the polysaccharide is sodium alginate, the cation includes calcium ions.

Description

Technical field [0001] The present invention relates to a two-dose local injection solution for submucosal injection and its use in manufacturing local injection solution. [0002] In this manual, the following abbreviations can be used: [0003] HA: Sodium Hyaluronate [0004] G-LA: Gellan Gum [0005] SA: Sodium Alginate [0006] Agar: Carrageenan [0007] SEH: Submucosal elevation height [0008] NS: normal saline [0009] The expression "%" means "mass percentage". Background technique [0010] In recent years, the number of endoscopic treatments for gastrointestinal cancer (gastric cancer, esophageal cancer, and colon cancer) has been increasing year by year. At the same time, difficult endoscopic treatment cases (large tumor size, fibrotic submucosa, tumors at difficult-to-treat sites) that require advanced treatment techniques are also increasing. [0011] The current endoscopic treatment of gastrointestinal cancer in Japan is based on two techniques, namely endoscopic mucosal resec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/02G01N33/15G01N33/50
CPCA61K47/36A61K9/0019A61K47/02A61P41/00A61K9/06
Inventor 广濑亮平中屋隆明伊藤义人
Owner KYOTO PREFECTURAL PUBLIC UNIV CORP
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