52 results about "Large tumor" patented technology

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

An antitumor agent for chemoradiotherapy of rectal cancer comprising a combination of TS-1 (a combination drug of tegafur, gimeracil, and oteracil potassium at a 1:0.4:1 molar ratio) and CPT-11 (irinotecan hydrochloride). The antitumor agent of the invention can achieve marked tumor volume reduction without causing major side effects, especially by coadministering it with preoperative radiation therapy. The volume of even large tumors that are refractory to surgical resection can be reduced by coadministering the antitumor agent of the invention with preoperative radiation therapy, making the subsequent surgical resection of the tumor easier.

Leptin was previously demonstrated to exert potent immune modulatory properties in several immune mediated disorders. The aim of the study was to determine leptin's anti-tumor effect in a murine model of human hepatocellular carcinoma (HCC). In vivo, Athymic T cell deficient (nude) mice transplanted with 1×106 human Hep3B cells, followed by administration of two daily intraperitoneal doses of 0.5 mg / gram leptin for 6 weeks. Leptin administration induced a significant reduction in tumor size and improved survival in nude mice. Histologically, tumors of leptin-administered mice featured increased inflammatory exudate in interphase areas. Leptin-induced tumor suppression was associated with a significant increase in peripheral natural killer (NK) cell number. Splenocytes from leptin-treated mice featured decreased expression of CIS mRNA. To determine which lymphocyte subset is a prerequisite for the anti tumor effect of leptin, T&B cell deficient (Scid) mice and T,B& NK deficient (Scid-Beige) mice were subcutaneously implanted with Hep3B tumor cells, with and without the daily intraperitoneal administration of 0.5 mg / gram leptin for 6 weeks. SCID mice featured leptin-associated tumor suppression similar to those of nude mice. In contrast, NK-deficient SCID-Beige mice developed larger tumors. To further establish natural killer cell's central role in mediation of leptin's anti-tumor effect, NK cells were incubated in vitro with increasing doses of leptin, demonstrating a dose-dependent increase in cytotoxic activity. Incubation of leptin with hepatoma cell line was found to induce a dose-dependent reduction in hepatoma cell proliferation, suggesting an additive direct anti-tumor effect. Further synergism in inhibition of hepatoma cell proliferation in vitro was achieved following addition of natural killer cells. HCC cells expressed leptin receptor mRNA, while addition of leptin induced increased mRMA expression of STAT2 and SOCS1 on tumor cell lines. Leptin administration induces a significant suppression of human HCC. This effect is mediated by induction of natural killer cell proliferation and activation, and by direct inhibition of tumor growth. Decreased natural killer cell expression of inhibitory CIS protein and over expression of the anti-proliferative STAT2 and SOCS1 proteins in HCC lines may underline both anti cancerous effects of leptin.

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

The present invention provides a generating system and method for a overlapping covering the ellipsoid ablation area, which comprises a main engine, a radio frequency needle device and a detection device for the ablation material. The present invention comprises a setting unit for the ablation area, which is used for setting size of the ablation area produced by the radio frequency needle; a layer setting unit, which is used for setting layer number required for covering the ablation material; a layered unit, which divides layers vertical to the high axial according to setting distance relative to center coordinate and the cross section layer equal to layers of the ablation area in the high axial; a layer covering unit, which is used for obtaining numbers of the ablation area demanded by the cross section and the spherical center coordinate of each ablation area relative to the ellipsoid coordinate system; a radio frequency needle device, which is used for generation of the ablation area in corresponding area, according to number of the ablation area sending out by the main engine and the position information. Therefore the largest tumor is covered by the least number of needle application, also damage to the normal tissue around the tumor is reduced.

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

The invention provides a microwave ablation simulation system. The types of ablation needles are received by virtue of a simulation computing module, and after configuring corresponding parameters to the types of the ablation needles in accordance with parameters of the different types of the ablation needles, an optimum scheme is computed out in accordance with a received 3D model of tumor and surrounding environment thereof as well as the corresponding parameters of the types of the ablation needles, so that the problem that normal tissues of a patient can get injured easily in the case that an ablation range is too large or tumor residue can be caused when the ablation range is too small; and then, the optimum ablation scheme, as tumor ablation simulation scheme information is outputted, so that an optimum multi-needle arranging microwave ablation scheme is offered to relatively large tumors.

A single-coil RF electrode, along with an associated method of operation, has been developed for use in an RF applicator, RFA apparatus or RFA system for heating tumors, including large tumors with a single heating session. The RF electrode generally has a helical geometry, although many variations exist, and is provided with an excitation current having a frequency that is sufficient for magnetic induction and coupling of various electric and magnetic fields to produce an electric field within the volume surrounded by the coil for directly applying heat to the tissue therein.

The invention relates to a construction method of an immortalized telocytes system. The construction method comprises the following steps: (1) digesting shorn off mouse lung tissue block in type-II collagenase, carrying out filtering and centrifuging, collecting cyte precipitate, culturing the cyte precipitate in a culture medium, after fibrocytes are attached to a wall, transferring supernate to another culture dish, culturing for 12 hours, then changing liquid, and continuing culturing for 3-5 days; (2) taking a trace spearhead as a cyte scraper to scrape off the fibrocytes, and after scraping off the fibrocytes repeatedly, observing a specificity structure telopode and identifying telocytes by an immune marker; and (3) taking the telocytes as host cells, infecting the host cells by using a retroviral vector which contains SV-40-large tumor antigen, and carrying out passage, screening and identifying. Even if the immortalized telocytes system is cultured to the 50th generation, the state is still stable, and therefore, the problem that the purity and the stability of the telocytes cannot be guaranteed by repeated separation and extraction in the prior art.

A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and / or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a low-viscosity but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

This invention provides a novel cancer treatment method in which plinabulin (t-butyl-dehydrophenylahistin or NPI-2358) and a taxane compound (such as docetaxel) are used in combination. Our study has shown that the optimum combination of injecting plinabulin after taxane compound has unexpected enhanced efficacy in large tumor populations in animal model and in NSCLC cancer patients compared to taxane compound treatment alone. In addition, this optimum combination can achieve unexpected safety effect in lowering unbearable side effects of taxane compound, including decreasing its neutropenia rates at all grades and decreasing G-CSF use in cancer patients.

This invention provides a novel cancer treatment method in which plinabulin (t-butyl-dehydrophenylahistin or NPI-2358) and a taxane compound (such as docetaxel) are used in combination. Our study has shown that the optimum combination of injecting plinabulin after taxane compound has unexpected enhanced efficacy in large tumor populations in animal model and in NSCLC cancer patients compared to taxane compound treatment alone. In addition, this optimum combination can achieve unexpected safety effect in lowering unbearable side effects of taxane compound, including decreasing its neutropenia rates at all grades and decreasing G-CSF use in cancer patients.

The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

The invention relates to the technical field of a lime kiln, and discloses slag removing equipment for a lime kiln; the equipment comprises a lime kiln main body, the inner left wall of the lime kilnmain body is fixedly connected with a sieve grid, and the right side of the lime kiln main body is provided with a slag removing box. The slag removing equipment for the lime kiln can introduce a relatively large tumor block scraped from a scraping plate into the slag removing box by setting the sieve grid, and a first rotating shaft is driven to rotate by arranging a drive device; and a second rotating shaft can be driven to rotate on a gear and a chain; the tumor block can be subjected to grinding ash treatment by the friction between a disintegrating slag tooth in a groove and the disintegrating slag tooth on the outer wall of the first rotating cylinder; the fitting surface is tight, and the grinding effect is good; through the rotation of a slag guide plate and a slag guide block, thetumor block can be continuously introduced into the friction part of the disintegrating slag; the grinded tumor block can be filtered by setting a filter screen; and the incompletely grinded tumor block can be grinded again; and the grinded lime can be introduced into the lime kiln main body again by an ash outlet pipe.

The invention discloses a culture method of high-memory phenotype tumor-infiltrating T lymphocytes. The culture method comprises the following steps of aseptically cutting tumor tissues and putting the tumor tissues into a culture solution, mechanically cutting and digesting tumor bodies under an aseptic cold chain condition to obtain a single-cell suspension, separating and extracting the tumor-infiltrating T lymphocytes, and obtaining the high-memory phenotype tumor-infiltrating T lymphocytes by adding the tumor-infiltrating T lymphocytes into a culture medium containing a separation induction culture solution for in-vitro amplification and induced differentiation, and culturing for 7-21 days, wherein the separation induction culture solution is a culture medium containing IL-2, IL-7 and IL-15 with the concentrations of 10ng / ml, 10ng / ml and 20ng / ml respectively. According to the method, the TIL cells are subjected to in-vitro amplification and induced differentiation by separating and inducing the culture solution, the high-memory phenotype TILs with efficient proliferation activity and strong tumor killing ability are obtained to the maximum extent, the method is simple and efficient, the proportion of the memory phenotype T lymphocytes is high, and the TILs can be used for treating advanced malignant melanoma.

The invention discloses a breast tumor segmenting method based on a multistage converting network, and relates to the technical field of medical image treatment. The breast tumor segmenting method comprises the following steps of firstly, enabling experts to classify tumor ultrasound images according to the size of tumors, performing repeated training according to classification results, and constructing a volume assessment network; then studying the characteristics of large tumors, performing amplifying treatment on small tumor ultrasound images to generate high-quality large tumor images, and constructing an image converting network; and finally, performing segmenting training on the large tumor ultrasound images and amplified small tumor ultrasound images, and after segmenting is completed, zooming the small tumor ultrasound images according to the same ratio, so as to complete the construction of whole-convolution neural network. According to the breast tumor segmenting method disclosed by the invention, segmenting can be performed according to the size of tumors in the tumor ultrasound images, and the segmenting precision and the segmenting efficiency of the small tumors can be especially improved. The invention also provides a breast tumor segmenting device based on a multistage converting network. The breast tumor segmenting device is combined with the breast tumor segmenting method, so that the segmenting of the small tumor ultrasound images is better completed.

The invention belongs to the field of biotechnology, and particularly relates to an oncolytic virus vaccine and a tumor treatment drug combing oncolytic virus vaccine with an immune checkpoint inhibitor. A brand-new oncolytic virus attenuated strain is provided by site-directed mutagenesis of wild-type virus matrix protein M of VSV (vesicular stomatitis virus). The attenuated strain can be used asa drug alone to treat tumors, and has safety and cure rate higher than those of wild-type viruses and other known attenuated strains. On the basis of the oncolytic virus attenuated strain, a vaccinethat can be used in tumor treatment is also provided by inserting NY-ESO-1 into the attenuated strain. The vaccine has high cure rate and high biological safety. On the basis of the vaccine, the invention also combines the vaccine with the immune checkpoint inhibitor to provide the drug capable of efficiently treating various tumors. In mouse lung cancer models, the cure rate can be astonishing, up to 87.5%, and the treatment effect on large tumors is also good.

The invention provides an establishment method of a tumor model capable of reflecting prostatic cancer to generate zone functional difference, which comprises the following steps: 1) using prostatic stroma cells, respectively extracting a peripheral zone normal tissue and a transformation zone normal tissue according to a Mcneal anatomical definition, and culturing primary stromal cells from the peripheral zone normal tissue and the transformation zone normal tissue, and identifying the component; 2) using a hormone independent insensitive humanized prostatic cancer cell line145, mixing stromal cells according to equicellular quantity and injecting into the skin of a naked mouse; and 3) after the tumor is formed, acquiring a specimen at same time point of largest tumor volume with less than 400mm<3> and then identifying. According to the invention, the tumor model is realized by a mode of culturing in a prostatic stroma epiderm transformation zone transformation zone al compound body, the clinic characteristics of promotion by the peripheral zone and tumor generation inhibition by the transformation zone can be embodied, and the tumor model provides powerful reference for researching a mechanism of the zone difference generated by prostatic cancer.

A medicine administration device for a medical oncology department comprises a waste liquid box, wherein a first through hole is formed in the middle of the bottom surface of the waste liquid box; a traditional Chinese medicine box is fixedly mounted on the top of the inside of the waste liquid box; a second through hole is formed in the bottom surface of the traditional Chinese medicine box; a third through hole is formed in the middle of the top surface of the waste liquid box; central axes of the first through hole, the second through hole and the third through hole are coaxial; a first vertical tube is fixedly mounted at the lower end of the first through hole; a fourth through hole is formed in the lower end surface of the first vertical tube; a second vertical tube is arranged in thefirst vertical tube; the upper end and the lower end of the second vertical tube are sealed; the lower end of the second vertical tube is positioned on the outside of the fourth through hole; and theupper end of the second vertical tube is positioned on the upper portion of the third through hole. The medicine administration device is suitable for the treatment on a patient with a large tumor tissue for a long period by directly acting traditional Chinese medicines on the tumor position, uniform spraying of traditional Chinese medicines and no-residual uniform absorption of waste liquid canbe implemented, a whole pharmacy process is automated completely, and the labor intensity of workers and burden of a patient are greatly reduced.

The invention discloses polydithioacetal and a preparation method and application thereof. The polydithioacetal has the advantages that the biocompatibility and the degradability are good; nano-particles can be formed by self-assembly in a water phase and can be used as a transport carrier of hydrophobic anti-cancer drugs; in an environment with lysosome acidity and high glutathione content in tumor cells, a hydrophobic anti-cancer drug in a particle core can be rapidly released, and the oxidative stress level in the tumor cells is amplified so that the drug resistance is effectively reversed,and huge clinical application potential is achieved.

The invention discloses a lung tumor segmentation method for large-area adhesion of lung boundary tissue in a CT image. The method comprises the following steps: extracting left and right pulmonary lobe parenchyma shapes from a lung CT image containing a large tumor, and constructing an input shape; then, according to the tumor-free lung CT image, constructing a prior shape by using a sparse similar shape linear combination model; selecting a deformation curve and a control point thereof on a priori shape, and selecting a target curve and a control point thereof on an input shape; using a curvilinear transformation method for correcting a large continuous error on the pulmonary parenchyma shape (namely an input shape), so that a complete pulmonary parenchyma contour including tumors is obtained, and a pulmonary parenchyma image is further obtained; and finally, segmenting the lung tumor on the lung parenchyma image by using a region growing method.

The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the lats protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of lats which comprise one or more domains of a lats protein. Antibodies to lats, its derivatives and analogs, are additionally provided. Methods of production of the lats proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. The invention also relates to recombinant plants and animals and methods of increasing the growth of edible plants and animals. In specific examples, isolated lats genes, from Drosophila, mouse, and human, and the sequences thereof, are provided.

The invention discloses a multi-channel radio frequency ablation system and a control method. The multi-channel radio frequency ablation system comprises a plurality of ablation electrodes, an audio module, a power generator module, a temperature measuring module, a channel output control module, a touch control module of a key knob module, a respiration monitoring system and a main control unit.The ablation electrodes are connected the channel output control module, and the audio module, the power generator module, the temperature measuring module, the channel output control module, the touch control module of the key knob module and the respiration monitoring system are connected with the main control unit. The invention realizes that several ablation electrodes simultaneously act on one tumor ablation, and the radio frequency signals between the electrodes do not interact with each other, thus realizing once ablation of large tumor, and the maximum ablation is 6-7cm tumors.

The present invention discloses alpha particle emitting, radioactive constructs capable of killing large tumors (>1 mm in diameter), or other cells involved in human or animal diseases such as virus infected cells, autoimmune cells, or other pathological cells, including normal cells, that are targets for destruction, to achieve a therapeutic result. The alpha-emitting constructs have high specific activity.

A medicine administration device for a medical oncology department comprises a waste liquid box, wherein a first through hole is formed in the middle of the bottom surface of the waste liquid box; a traditional Chinese medicine box is fixedly mounted on the top of the inside of the waste liquid box; a second through hole is formed in the bottom surface of the traditional Chinese medicine box; a third through hole is formed in the middle of the top surface of the waste liquid box; central axes of the first through hole, the second through hole and the third through hole are coaxial; a first vertical tube is fixedly mounted at the lower end of the first through hole; a fourth through hole is formed in the lower end surface of the first vertical tube; a second vertical tube is arranged in thefirst vertical tube; the upper end and the lower end of the second vertical tube are sealed; the lower end of the second vertical tube is positioned on the outside of the fourth through hole; and theupper end of the second vertical tube is positioned on the upper portion of the third through hole. The medicine administration device is suitable for the treatment on a patient with a large tumor tissue for a long period by directly acting traditional Chinese medicines on the tumor position, uniform spraying of traditional Chinese medicines and no-residual uniform absorption of waste liquid canbe implemented, a whole pharmacy process is automated completely, and the labor intensity of workers and burden of a patient are greatly reduced.

The present invention discloses alpha particle emitting, radioactive constructs capable of killing large tumors (>1 mm in diameter), or other cells involved in human or animal diseases such as virus infected cells, autoimmune cells, or other pathological cells, including normal cells, that are targets for destruction, to achieve a therapeutic result. The alpha emitting constructs have high specific activity.