Drug network pharmacology intelligent and quantitative analysis method and system based on network target
A technology of network pharmacology and quantitative analysis, applied in the field of drug network pharmacology intelligence and quantitative analysis and system based on network targets
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Embodiment 1
[0105] Embodiment 1: Liuwei Dihuang Wan embodiment
[0106] Previous clinical studies have found that Liuwei Dihuang Pills, a famous Chinese medicine prescription, has a good clinical effect in the treatment of various complex diseases, such as inhibiting the transformation of esophagus and other digestive tract inflammation and cancer [15] , however, its intrinsic mechanism of inhibiting gastrointestinal inflammation and cancer transformation, as well as the group of active ingredients are still unclear. The inventors used UNIQ, a network target intervention effect model, for the quantitative evaluation of the drug efficacy, mechanism analysis and discovery of active ingredient groups of Liuwei Dihuang Pills, a famous Chinese medicine prescription, in inhibiting the transformation of gastrointestinal inflammation and cancer.
[0107] Through the analysis of the UNIQ algorithm, the network regulation mechanism of Liuwei Dihuang Pills in inhibiting the transformation of gastroi...
Embodiment 2
[0137] Embodiment 2: Compound Huangdai tablet embodiment
[0138] Compound Huangdai tablet has been widely reported and has good clinical effect in the treatment of acute promyelocytic leukemia, but its mechanism of action and material basis of drug effect are still not completely clear. Using the network target intervention model UNIQ proposed by the present invention, we found that the main active ingredients such as arsenic tetrasulfide, indirubin and tanshinone IIA can regulate multiple interrelated biological modules of acute promyelocytic leukemia. Furthermore, the model was used to explore the biological basis of the compatibility law of its "junchenzuoshi" and successfully found out the network intervention module of the four traditional Chinese medicines in compound Huangdai Tablets. The active ingredients contained in the monarch medicine realgar can regulate acute promyelocytic leukemia The biological network module where the fusion protein PML-RARA is located, the ...
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