Embedded type graded drug release three-dimensional rack and preparation method thereof

A three-dimensional stent and embedded technology, which is applied in the direction of stents, drug devices, and other medical devices, can solve the problems of inability to realize drug gradient loading and distribution, uneven drug distribution, and single type of stent drug loading.

Inactive Publication Date: 2012-07-11
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Uniformly mixed drug loading, single type of drug loading on the stent, uneven drug distribution and gradient loading and distribution of drugs cannot be achieved
Soaking or dripping adsorption dru...

Method used

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  • Embedded type graded drug release three-dimensional rack and preparation method thereof
  • Embedded type graded drug release three-dimensional rack and preparation method thereof
  • Embedded type graded drug release three-dimensional rack and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment one: see figure 1 , the embedded three-dimensional stent for graded release of drugs is composed of an inner layer blank (1) and an outer wrapping blank (2), and is characterized in that:

[0044] 1), the inner layer form (1) is a calcium phosphate form uniformly mixed with drug D1, the slurry used for the preparation of the form: the content of calcium phosphate is 10%±0.5%, the content of drug D1 is 0.0017, and the balance for distilled water;

[0045] 2), the outer wrapping form (2) is a calcium phosphate form uniformly mixed with drug D2, wherein drug D2 is a different type of drug from drug D1, and the slurry used for the preparation of the form is: the content of calcium phosphate is 20 %±0.5%, the content of drug D2 is 0.0085, and the balance is distilled water;

[0046] 3) The drug content = drug mass mg / mass g of biological experiment living sample.

[0047] The preparation process steps of this support are as follows:

[0048] ...

Embodiment 2

[0051] Embodiment two: see figure 2 , the embedded three-dimensional stent for graded drug release is composed of an inner shape (1), a middle wrapping shape (3) and an outer shape (2), and is characterized in that:

[0052] 1), the inner layer form (1) is a calcium phosphate form uniformly mixed with drug D1, the slurry used for the preparation of the form: the content of calcium phosphate is 10%±0.5%, the content of drug D1 is 0.0020, and the balance for distilled water;

[0053] 2) The middle layer shape (3) is a calcium phosphate shape uniformly mixed with drug D2. Drug D2 is a different type of drug from drug D1. The slurry used for the preparation of the shape body is: the content of calcium phosphate is 20%±0.5 %, the content of drug D2 is 0.0017, and the balance is distilled water;

[0054] 3), the outer wrapping shape (2) is a calcium phosphate shape uniformly mixed with drug D3, wherein drug D3 is a different type of drug from drug D1 and drug D2, an...

Embodiment 3

[0061] Embodiment three: This example is basically the same as Example 1. The drug D1 is deferoxamine, and the drug D2 is the small molecule compound OIC-006. The preparation process steps of this stent are as follows:

[0062] First, use a small negative type ( image 3 ) Forming the inner layer blank SD1 of the drug-loaded stent: First, uniformly mix the hypoxic mimetic compound deferoxamine (drug D1) that promotes osteogenesis and the slurry with a calcium phosphate content of 10%±0.5% to obtain the inner layer stent slurry. Next, inject the inner layer stent slurry into the small-size negative type, pre-freeze the negative type in the environment of -10°C ± 0.5°C for 12h ± 0.5h, and remove the mold to obtain the inner layer blank SD1 of the stent encapsulating deferoxamine ( Figure 6 );

[0063] Second, put the stent inner layer blank SD1 obtained in the first step into a large-size negative ( Figure 4 ), after mixing the small molecule compound OIC-006 and ...

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Abstract

The invention relates to an embedded type graded drug release three-dimensional rack and a preparation method of the rack. A rack inner-layer shaped body with high porosity is wrapped by a rack outer-layer shaped body with low porosity to form an embedded bi-layer structural rack. The classes of drugs carried by the inner layer and the outer layer of the rack are different. The graded distribution of drug classes and the graded distribution of rack microstructures are realized in the same rack, thereby obtaining the embedded two-graded drug release artificial rack. The preparation process of the multi-graded drug release rack comprises the three steps, namely, (1) freeze-forming of the drug carrying rack inner-layer shaped body; (2) freeze-forming of the drug carrying rack outer-layer wrapping shaped body; and (3) drying the embedded rack in a low temperature and vacuum. In the embedded multi-layer rack prepared in the invention, the content of calcium phosphate and the drug classes in a composite slurry used in each layer of the rack are respectively different; the degradation rate of the rack is related to the solid content of solid phase; as the solid content of the slurry is different, the degradation rate of the prepared rack is different; and the release rate of the drug is influenced by the rack degradation.

Description

technical field [0001] The invention relates to a three-dimensional artificial bone scaffold and a preparation method thereof in the field of tissue engineering, in particular to an embedded graded drug-releasing degradable three-dimensional scaffold and a preparation method thereof. Background technique [0002] Bone defect repair, especially large bone repair has always been a thorny problem in clinical medicine and a research hotspot in the field of tissue engineering. At present, in vivo transplantation is a commonly used bone repair method, mainly including: autologous bone transplantation, but the material is limited and the source is limited; allogeneic bone transplantation, not only the material source is limited but also has a high risk of infection. Therefore, artificial bone scaffolds have attracted extensive attention from researchers in the field of tissue engineering, and they have begun to design, prepare and apply artificial bone as a three-dimensional supp...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61M31/00
Inventor 林柳兰周丽萍王志坤胡庆夕方明伦
Owner SHANGHAI UNIV
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