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Drug-loaded guided tissue regeneration membrane and preparation method thereof

A technology to guide tissue regeneration and drug loading, applied in medical science, surgery, etc., can solve few problems such as antibacterial properties

Active Publication Date: 2017-06-06
BEIJING UNIV OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no bacteriostatic guided tissue regeneration membrane product available
There are few studies on antibacterial properties of new guided tissue regeneration membranes under research

Method used

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  • Drug-loaded guided tissue regeneration membrane and preparation method thereof
  • Drug-loaded guided tissue regeneration membrane and preparation method thereof
  • Drug-loaded guided tissue regeneration membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Dissolve 2 g of polycaprolactone and 0.2 g of metronidazole in a mixed solvent of 7.2 g of DMF and 10.8 g of DCM, and stir magnetically at room temperature for 12 hours to obtain polycaprolactone with a concentration of 10% (w / w), metronidazole A spinning solution with a mass ratio of azole to polycaprolactone of 10%.

[0057] 2. Take the solution for electrospinning, use a stainless steel drum as the receiving device, the drum speed is 200rpm, the voltage is 10KV, the receiving distance is 16cm, the spinning liquid inlet rate is 4mL / h, and the spinning is 5h. A single-layer guided tissue regeneration membrane with a thickness of about 250 μm was obtained.

[0058] 3. Dry the obtained fiber membrane in a fume hood at room temperature for 72 hours to ensure that the residual solvent is fully volatilized.

Embodiment 2

[0060] 1. Dissolve polycaprolactone and metronidazole in a mixed organic solvent of DCM / DMF=7:3, and stir magnetically at room temperature for 12 hours to obtain a concentration of polycaprolactone of 20%, and the concentration of metronidazole and polycaprolactone The spinning solution with a mass ratio of 50%;

[0061] 2. Electrospinning at room temperature, with a stainless steel drum as the receiving device, the drum rotation rate is 600rpm, the spinning solution flow rate is 3mL / h, the voltage is 12kV, the receiving distance is 15cm, and the spinning is 5h, and a single-layer guide with a thickness of about 200μm is obtained. Tissue regeneration membrane.

[0062] 3. Dry the obtained fiber membrane in a fume hood at room temperature for 72 hours to fully volatilize the residual solvent.

Embodiment 3

[0064] 1. Dissolve 1.5g of polycaprolactone and 0.3g of tetracycline hydrochloride in 13.5g of trifluoroethanol, and magnetically stir at room temperature for 12 hours to obtain solution A;

[0065] 2. Dissolve 1.5g of polylactic acid and 0.3g of tetracycline hydrochloride in 13.5g of trifluoroethanol, and magnetically stir at room temperature for 12 hours to obtain solution B;

[0066] 3. Mix solution A and solution B, and magnetically stir for 12 hours to obtain a spinning solution with a mass ratio of polycaprolactone and polylactic acid of 1:1, a polymer concentration of 10%, and a mass ratio of drug to polymer of 20%. C;

[0067] 4. Electrospinning with spinning solution C at room temperature, with a stainless steel drum as the receiving device, the rotation rate of the drum is 200rpm, the flow rate of the spinning solution is 2mL / h, the voltage is 13kV, the receiving distance is 20cm, and the spinning time is 10h to obtain a thickness of 250μm Left and right monolayer e...

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Abstract

The invention provides a drug-loading type guided tissue regeneration membrane and preparation method thereof. Polycaprolactone and other biodegradable aliphatic polyesters are used as raw materials and added with an antibacterial drug, and the materials are prepared into a single-layer guided tissue regeneration membrane through an electrospinning method. Or, polycaprolactone and degradable aliphatic polyester material are used as a dense layer, degradable natural polymer material and bio active particles are used as a loose layer, and an antibacterial drug is added to the dense layer; and the layers are prepared into a double-layer guided tissue regeneration membrane with different pore structures and biological activity through a layer by layer electrostatic spinning method. The membrane material provided by the invention has excellent biocompatibility, mechanical properties and degradation property consistent with tissue repair process, can effectively prevent the growth of fibroblasts towards tissue defects, at the same time promote the regeneration repair of tissue, does not have to taken out through a secondary operation; and the membrane material can effectively inhibit bacteria infection and inflammation after the operation, can be widely used in medical fields, such as guided tissue regeneration, postoperative adhesion prevention and drug delivery membrane.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a guiding tissue regeneration membrane material with polycaprolactone as the main base material and loaded with antibacterial drugs and a preparation method thereof. Background technique [0002] Due to long-term tooth loss, periodontal disease, trauma, cleft palate, and bone defects caused by maxillofacial tumors, denture restoration and implant placement are often impossible, and bone restoration must be used for reconstruction. Guided tissue regeneration (GTR), which uses biofilm to guide periodontal tissue regeneration, is considered to be the most effective oral bone defect repair technique in the past two decades, and has been widely used in periodontal clinics. Guided tissue regeneration technology is to place a membrane between the periodontal connective tissue flap and the root as a barrier to prevent the growth of the gingiva in the connective tissue, sel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16A61L31/14A61L31/04A61L31/02
Inventor 张立群薛佳佳石锐田伟陈大福
Owner BEIJING UNIV OF CHEM TECH
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