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Method for manufacturing magnesium phosphate bioceramic functional gradient bone regeneration scaffold

A functionally gradient and bioceramic technology, applied in tissue regeneration, drug delivery, pharmaceutical formulations, etc., can solve problems such as the size of pores in difficult scaffolds, achieve low cost, promote adhesion, and print various effects

Inactive Publication Date: 2019-08-20
JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the traditional preparation process, it is difficult to precisely control the pore size of the scaffold, and the difficulty and cost of manufacturing FGM materials far exceed its application value. also very little

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: A method for making a magnesium phosphate bioceramic functionally graded bone regeneration scaffold, comprising the following steps:

[0023] (1) Prepare MgP powder, Mg(OH )2 with H 3 PO 4 Mix and add water at a molar ratio of 3:2 to form an aqueous solution. The mixed solution is continuously stirred for 10 hours and then allowed to stand for 24 hours to form a precipitate. Filter the formed precipitate and dry it in an oven at 80° for 2 days, then heat-treat it at 850°C 6h, finally the obtained powder is ground in a grinder to an average particle size of 3 μm;

[0024] (2) Prepare the MgP scaffold mixture, mix the obtained MgP powder with NaCL with a particle size of 25 μm in a mass ratio of 3:1, then add 1% hydroxypropyl methylcellulose and MgP and NaCL mixed powder Mix evenly in 30% ethanol solution, the mass volume ratio of powder to liquid is 1:0.75, to obtain the mixed solution of MgP and NaCl, set aside;

[0025] (3) Prepare the HIPS porous sup...

Embodiment 2

[0027] Embodiment 2: A method for making a magnesium phosphate bioceramic functionally graded bone regeneration scaffold, comprising the following steps:

[0028] (1) Prepare MgP powder, Mg(OH )2 with H 3 PO 4 Mix and add water at a molar ratio of 3:2 to form an aqueous solution. The mixed solution is continuously stirred for 10 hours and then allowed to stand for 24 hours to form a precipitate. Filter the formed precipitate and dry it in an oven at 80° for 2 days, then heat-treat it at 850°C 6h, finally the obtained powder is ground in a grinder to an average particle size of 4 μm;

[0029](2) Prepare the MgP scaffold mixture, mix the obtained MgP powder with NaCL with a particle size of 50 μm in a mass ratio of 1:1, then add 1% hydroxypropyl methylcellulose and MgP and NaCL mixed powder Mix evenly in 30% ethanol solution, the mass volume ratio of powder to liquid is 1:0.75, to obtain the mixed solution of MgP and NaCl, set aside;

[0030] (3) Prepare the HIPS porous supp...

Embodiment 3

[0032] Embodiment 3: A method for making a magnesium phosphate bioceramic functionally graded bone regeneration scaffold, comprising the following steps:

[0033] (1) Prepare MgP powder, Mg(OH )2 with H 3 PO 4 Mix and add water at a molar ratio of 3:2 to form an aqueous solution. The mixed solution is continuously stirred for 10 hours and then allowed to stand for 24 hours to form a precipitate. Filter the formed precipitate and dry it in an oven at 80° for 2 days, then heat-treat it at 850°C 6h, finally the obtained powder is ground in a grinder to an average particle size of 4 μm;

[0034] (2) Prepare the MgP scaffold mixture, mix the obtained MgP powder with NaCL with a particle size of 40 μm in a mass ratio of 2:1, then add 1% hydroxypropyl methylcellulose and MgP and NaCL mixed powder Mix evenly in 30% ethanol solution, the mass volume ratio of powder to liquid is 1:0.75, to obtain the mixed solution of MgP and NaCl, set aside;

[0035] (3) Prepare the HIPS porous sup...

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Abstract

The invention discloses a method for manufacturing a magnesium phosphate bioceramic functional gradient bone regeneration scaffold. The method comprises the following steps: (1) preparing MgP powder;(2) preparing a MgP scaffold mixed solution; (3) preparing a HIPS porous support scaffold through 3D printing; and (4) preparing a blank MgP scaffold so as to obtain the MgP functional gradient bone regeneration scaffold. The scaffold material has a multi-scale pore structure, the inner layer has loose pores, and the pores are 300-500 [mu]m, not only can be beneficial to cell growth, but also canbe rapidly degraded and promote the formation of a natural bone structure; the outer layer scaffold is provided with dense pores, and the pores are 100-200 [mu]m, provide enough mechanical strength for the scaffold, provide longer degradation time, provide a stable regeneration microenvironment for internal bone regeneration, and have the effect of promoting bone defect regeneration and repair; and meanwhile, the surface of the scaffold material is also provided with micropores which are about 50 [mu]m and are beneficial to the adhesion of cells.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to the material and preparation of functionally graded scaffolds used for regeneration and repair of bone defects. Background technique [0002] Due to various reasons such as tumor, trauma and osteonecrosis, large bone tissue defects can be caused. Natural bone substitute materials, such as autologous bone or allogeneic bone, can be used for the repair and reconstruction of bone tissue, but the clinical application of natural bone substitute materials has restricted. In recent years, based on the rapid development of materials science and tissue engineering, it has become possible to construct artificial bone substitute materials. [0003] Bioceramics is a class of bioactive materials represented by hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), which have good biosafety, biocompatibility, osseointegration, osteoconductive ) ability and chemical composition simil...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/12A61L27/56A61L27/16A61L27/50B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/10A61L27/12A61L27/16A61L27/50A61L27/56A61L2400/12A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L25/06
Inventor 庄海卜寿山张金灿张怡雯龚春玲
Owner JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
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